NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	I6I02_RS03625	Genome accession	NZ_CP066093
Coordinates	829467..830141 (+)	Length	224 a.a.
NCBI ID	WP_002891134.1	Uniprot ID	J7TS49
Organism	Streptococcus salivarius strain FDAARGOS_1045
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 824467..835141

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6I02_RS03605 (I6I02_03605)	-	825582..826154 (-)	573	WP_022496698.1	ECF transporter S component	-
I6I02_RS03610 (I6I02_03610)	coaC	826183..826728 (-)	546	WP_198463840.1	phosphopantothenoylcysteine decarboxylase	-
I6I02_RS03615 (I6I02_03615)	-	826721..827404 (-)	684	WP_198463841.1	phosphopantothenate--cysteine ligase	-
I6I02_RS03620 (I6I02_03620)	-	827598..829268 (+)	1671	WP_198463842.1	formate--tetrahydrofolate ligase	-
I6I02_RS03625 (I6I02_03625)	ciaR	829467..830141 (+)	675	WP_002891134.1	response regulator transcription factor	Regulator
I6I02_RS03630 (I6I02_03630)	ciaH	830131..831546 (+)	1416	WP_198463843.1	sensor histidine kinase	Regulator
I6I02_RS03635 (I6I02_03635)	rpsT	831624..831860 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
I6I02_RS03640 (I6I02_03640)	coaA	831930..832850 (-)	921	WP_013990467.1	type I pantothenate kinase	-
I6I02_RS03645 (I6I02_03645)	-	832963..833553 (+)	591	WP_013990468.1	class I SAM-dependent methyltransferase	-
I6I02_RS03650 (I6I02_03650)	-	833550..834827 (+)	1278	WP_013990469.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25362.02 Da Isoelectric Point: 4.2897

                                >NTDB_id=517353 I6I02_RS03625 WP_002891134.1 829467..830141(+) (ciaR) [Streptococcus salivarius strain FDAARGOS_1045]

MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY

FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

Download Length: 675 bp

                                >NTDB_id=517353 I6I02_RS03625 WP_002891134.1 829467..830141(+) (ciaR) [Streptococcus salivarius strain FDAARGOS_1045]

ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT

TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT

TGCCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGCGAAAAAGGTGTAACGACTCCTGTTCTTATCATGACGGCA

AAGGAAAGTCTAGACGATAAGGGACACGGCTTTGAACTGGGGGCAGATGACTATCTAACCAAACCTTTCTATTTAGAAGA

GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTCGGTGATGTTCGTG

TCAATCTTGCTACAAATTCAACCTTTGTGGGTGATAAAGAGGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAT

TTCTTACAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT

ATCGGTTGTTGAAGTATATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA

GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	J7TS49

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362

Detailed information NTG0517353