Detailed information NTG0516841

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: I6H72_RS03500
• Genome accession: NZ_CP066055
• Coordinates: 710795..711541 (+)
• Length: 248 a.a.
• NCBI ID: WP_041786327.1
• Uniprot ID: -
• Organism: Streptococcus constellatus strain FDAARGOS_1015
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 705795..716541

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H72_RS03470 (I6H72_03470)	-	706132..707190 (-)	1059	WP_198458308.1	thioredoxin family protein	-
I6H72_RS03475 (I6H72_03475)	-	707646..707876 (-)	231	WP_006270136.1	Blp family class II bacteriocin	-
I6H72_RS03480 (I6H72_03480)	-	708106..708426 (-)	321	WP_198458419.1	hypothetical protein	-
I6H72_RS03485 (I6H72_03485)	-	708508..708783 (-)	276	WP_048800278.1	hypothetical protein	-
I6H72_RS03490 (I6H72_03490)	-	709460..709681 (-)	222	WP_048800277.1	Blp family class II bacteriocin	-
I6H72_RS03495 (I6H72_03495)	-	709913..710626 (+)	714	WP_048800552.1	CPBP family intramembrane glutamic endopeptidase	-
I6H72_RS03500 (I6H72_03500)	comE/blpR	710795..711541 (+)	747	WP_041786327.1	response regulator transcription factor	Regulator
I6H72_RS03505 (I6H72_03505)	-	711942..712853 (+)	912	WP_232619602.1	GHKL domain-containing protein	-
I6H72_RS03510 (I6H72_03510)	-	712898..713047 (-)	150	WP_096362645.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
I6H72_RS03515 (I6H72_03515)	-	713144..714505 (-)	1362	WP_020999319.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 248 a.a.
• Molecular weight: 28742.18 Da
• Isoelectric Point: 7.0486

>NTDB_id=516841 I6H72_RS03500 WP_041786327.1 710795..711541(+) (comE/blpR) [Streptococcus constellatus strain FDAARGOS_1015]
MNIFILEDDLTQQYYMETIVEEIIEKHHLQYHHFEVVGKPKQLLEAISEKGSHQIFFLDIEIKTEEEKGLDVAKKIREID
PYAIIVFVTSHSELMPTAFKLQVGALDYLDKSLSKEIFKKRIETALLHTESLTGKGLADDALLFETPHTQIQVPFKDILY
IETSSRPHRLVLYTHRGRTEFTANLLDILKKEKRFYQCHRSFVVNPANVHQVDKVNHILHFQNGATCLISRAKIKGLTEA
IAALHRRE

Nucleotide

• Length: 747 bp

>NTDB_id=516841 I6H72_RS03500 WP_041786327.1 710795..711541(+) (comE/blpR) [Streptococcus constellatus strain FDAARGOS_1015]
ATGAATATTTTTATTTTAGAAGATGATCTTACTCAACAATATTATATGGAGACTATTGTTGAAGAAATTATCGAAAAACA
TCATCTTCAATATCATCATTTTGAAGTTGTTGGAAAACCTAAACAATTACTAGAAGCCATATCTGAGAAAGGAAGCCATC
AGATTTTCTTTTTAGACATTGAAATCAAAACCGAGGAAGAAAAGGGCTTAGACGTTGCTAAAAAGATACGCGAGATAGAT
CCTTATGCCATCATTGTCTTTGTAACCAGTCATTCTGAATTGATGCCTACAGCGTTTAAGCTGCAAGTGGGTGCCCTTGA
TTATCTTGACAAATCGTTATCAAAAGAAATCTTTAAAAAACGGATCGAAACTGCACTGCTACATACTGAAAGCCTAACAG
GTAAAGGGCTGGCAGACGATGCTCTTCTCTTTGAAACACCTCATACACAAATACAAGTGCCATTTAAAGATATTCTTTAT
ATTGAAACTTCCTCTCGTCCTCACCGCTTAGTTCTTTACACACATAGAGGACGTACGGAATTTACTGCTAATCTTTTAGA
TATTTTAAAAAAAGAAAAACGGTTCTACCAATGTCATCGCTCCTTTGTTGTTAATCCAGCTAATGTCCATCAAGTGGATA
AGGTAAATCATATCCTTCACTTCCAGAATGGTGCTACTTGTCTTATTTCCAGAGCAAAAATAAAAGGGTTAACAGAAGCC
ATTGCAGCCCTGCACCGGAGGGAATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	50.202	99.597	0.5
comE/comE1	Streptococcus equinus JB1	44.304	95.565	0.423
comE	Streptococcus pneumoniae Rx1	37.398	99.194	0.371
comE	Streptococcus pneumoniae D39	37.398	99.194	0.371
comE	Streptococcus pneumoniae R6	37.398	99.194	0.371
comE	Streptococcus pneumoniae TIGR4	37.398	99.194	0.371
comE	Streptococcus mitis NCTC 12261	37.398	99.194	0.371
comE	Streptococcus mitis SK321	37.398	99.194	0.371
comE	Streptococcus infantis strain Atu-4	36.992	99.194	0.367