Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   KW2_RS08180 Genome accession   NC_022369
Coordinates   1734080..1734748 (-) Length   222 a.a.
NCBI ID   WP_011834734.1    Uniprot ID   A2RJ99
Organism   Lactococcus cremoris subsp. cremoris KW2     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1729080..1739748
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KW2_RS08165 (kw2_1639) yidD 1730210..1730482 (-) 273 WP_021037613.1 membrane protein insertion efficiency factor YidD -
  KW2_RS08170 (kw2_1640) - 1730603..1732345 (-) 1743 WP_021037614.1 1-deoxy-D-xylulose-5-phosphate synthase -
  KW2_RS08175 (kw2_1641) ciaH 1732494..1733864 (-) 1371 WP_011676680.1 sensor histidine kinase Regulator
  KW2_RS08180 (kw2_1642) ciaR 1734080..1734748 (-) 669 WP_011834734.1 response regulator transcription factor Regulator
  KW2_RS08185 (kw2_1643) - 1734926..1735900 (-) 975 WP_011834733.1 LacI family DNA-binding transcriptional regulator -
  KW2_RS08190 (kw2_1644) - 1736052..1738307 (-) 2256 WP_021037615.1 glycoside hydrolase family 65 protein -

Sequence

Protein


Download         Length: 222 a.a.        Molecular weight: 25502.39 Da        Isoelectric Point: 4.4864

>NTDB_id=51674 KW2_RS08180 WP_011834734.1 1734080..1734748(-) (ciaR) [Lactococcus cremoris subsp. cremoris KW2]
MIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLIMTA
KESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLSYGNIRLNLSNKSTLVDDQPVDLIGKEFDLVV
YLMQNQNVILPKEQIFDRIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR

Nucleotide


Download         Length: 669 bp        

>NTDB_id=51674 KW2_RS08180 WP_011834734.1 1734080..1734748(-) (ciaR) [Lactococcus cremoris subsp. cremoris KW2]
ATGATTAAAATTTTATTAGTGGAGGACGATTTATCACTCTCTAAATCTGTTTACGATTTCTTAAAATCTTTTGCACAAGT
GAAACAAGTTTATGATGGAGTTGAAGGACTCTACGAAGCAGAATTGGGAATTTATGATTTGATTTTGCTTGATTTGATGC
TTCCAGAAAAAAATGGTTTTGAAGTCTTAAAAGAACTCCGTGAACAAAATGTGGATACACCTGTCTTAATTATGACTGCC
AAAGAATCTTTGGATGATAAAATGCATGGTTTTGATATTGGGGCAGATGATTATTTAACAAAACCTTTCTATTTAGATGA
ACTTAAAGCACGAATTCAAGCACTTTTAAAACGGACAGGGAAATTGGAAGATTCCAATGGTTTGTCTTATGGAAATATTC
GTTTGAATTTATCAAATAAATCAACTTTAGTTGATGACCAACCTGTTGATTTAATTGGTAAAGAGTTTGATTTAGTCGTT
TATTTAATGCAAAACCAAAATGTTATTTTGCCAAAAGAGCAGATTTTTGACCGGATTTGGGGTTATGATAGTGACACAAC
TGTGACGGTTGTTGAGGTTTATATGAGTAAAATCCGGAAAAAATTGAAAGATACAGAATTTGTCAATAATCTTTCAACTT
TGCGAAATGTTGGCTATATCTTGAGATAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-221)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A2RJ99

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

74.324

100

0.743
  ciaR Streptococcus pneumoniae D39

74.324

100

0.743
  ciaR Streptococcus pneumoniae R6

74.324

100

0.743
  ciaR Streptococcus pneumoniae TIGR4

74.324

100

0.743
  ciaR Streptococcus mutans UA159

72.523

100

0.725
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.396
  covR Streptococcus salivarius strain HSISS4

36.889

100

0.374
  vicR Streptococcus mutans UA159

34.764

100

0.365
  micA Streptococcus pneumoniae Cp1015

34.483

100

0.36

Multiple sequence alignment