Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   I6G23_RS06245 Genome accession   NZ_CP065735
Coordinates   966184..966876 (+) Length   230 a.a.
NCBI ID   WP_003130756.1    Uniprot ID   S6EZK2
Organism   Lactococcus lactis strain FDAARGOS_866     
Function   repress the expression of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 961184..971876
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6G23_RS06215 (I6G23_06215) - 962146..962982 (+) 837 WP_003130766.1 metallophosphoesterase -
  I6G23_RS06220 (I6G23_06220) - 963043..963573 (+) 531 WP_003130764.1 CHAP domain-containing protein -
  I6G23_RS06225 (I6G23_06225) - 964058..964420 (+) 363 WP_010906050.1 TIGR02328 family protein -
  I6G23_RS06230 (I6G23_06230) - 964502..964966 (+) 465 WP_003130761.1 hypothetical protein -
  I6G23_RS06235 (I6G23_06235) - 965122..965367 (+) 246 WP_003130760.1 type B 50S ribosomal protein L31 -
  I6G23_RS06240 (I6G23_06240) - 965498..966028 (+) 531 WP_003130758.1 YceD family protein -
  I6G23_RS06245 (I6G23_06245) covR 966184..966876 (+) 693 WP_003130756.1 response regulator transcription factor Regulator
  I6G23_RS06250 (I6G23_06250) covS 966884..968359 (+) 1476 WP_010906048.1 HAMP domain-containing histidine kinase Regulator
  I6G23_RS06255 (I6G23_06255) - 968542..969783 (+) 1242 WP_003130753.1 ammonium transporter -
  I6G23_RS06260 (I6G23_06260) - 969915..970256 (+) 342 WP_010906046.1 P-II family nitrogen regulator -

Sequence

Protein


Download         Length: 230 a.a.        Molecular weight: 26684.36 Da        Isoelectric Point: 5.1273

>NTDB_id=513682 I6G23_RS06245 WP_003130756.1 966184..966876(+) (covR) [Lactococcus lactis strain FDAARGOS_866]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide


Download         Length: 693 bp        

>NTDB_id=513682 I6G23_RS06245 WP_003130756.1 966184..966876(+) (covR) [Lactococcus lactis strain FDAARGOS_866]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACAGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(6-115)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB S6EZK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Lactococcus lactis subsp. lactis strain DGCC12653

100

100

1
  covR Streptococcus salivarius strain HSISS4

68.421

99.13

0.678
  vicR Streptococcus mutans UA159

45.887

100

0.461
  micA Streptococcus pneumoniae Cp1015

43.478

100

0.435
  ciaR Streptococcus mutans UA159

37.611

98.261

0.37
  ciaR Streptococcus pneumoniae Rx1

36.726

98.261

0.361
  ciaR Streptococcus pneumoniae D39

36.726

98.261

0.361
  ciaR Streptococcus pneumoniae R6

36.726

98.261

0.361
  ciaR Streptococcus pneumoniae TIGR4

36.726

98.261

0.361