Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SPAF_RS04235 Genome accession   NC_017905
Coordinates   837440..838120 (+) Length   226 a.a.
NCBI ID   WP_037607818.1    Uniprot ID   A0A2I1TVC1
Organism   Streptococcus parasanguinis FW213     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 832440..843120
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPAF_RS04210 (Spaf_0808) - 833390..834100 (-) 711 WP_014713137.1 LytTR family DNA-binding domain-containing protein -
  SPAF_RS04215 (Spaf_0809) - 834207..835163 (+) 957 WP_045764003.1 ABC transporter ATP-binding protein -
  SPAF_RS04220 (Spaf_0810) - 835165..835887 (+) 723 WP_014713139.1 ABC transporter permease -
  SPAF_RS04225 (Spaf_0812) - 836040..836573 (-) 534 WP_014713140.1 BioY family transporter -
  SPAF_RS04230 (Spaf_0813) - 836780..837304 (+) 525 WP_014713141.1 hypothetical protein -
  SPAF_RS04235 (Spaf_0814) ciaR 837440..838120 (+) 681 WP_037607818.1 response regulator transcription factor Regulator
  SPAF_RS04240 (Spaf_0815) ciaH 838104..839474 (+) 1371 WP_013903377.1 HAMP domain-containing sensor histidine kinase Regulator
  SPAF_RS04245 (Spaf_0816) - 839490..839870 (+) 381 WP_003006623.1 VOC family protein -
  SPAF_RS04250 (Spaf_0817) - 839981..841363 (+) 1383 WP_014713142.1 polysaccharide deacetylase family protein -
  SPAF_RS04255 (Spaf_0818) - 841407..842492 (-) 1086 WP_014713143.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25709.43 Da        Isoelectric Point: 4.3559

>NTDB_id=51134 SPAF_RS04235 WP_037607818.1 837440..838120(+) (ciaR) [Streptococcus parasanguinis FW213]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGIYDLILLDLMLPEKDGFHVLKELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKVNENTLNYGNLKVNLSTNSTYVDGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVESLQTLRSVGYILKDANQN

Nucleotide


Download         Length: 681 bp        

>NTDB_id=51134 SPAF_RS04235 WP_037607818.1 837440..838120(+) (ciaR) [Streptococcus parasanguinis FW213]
ATGATTAAAATTCTATTGGTCGAAGATGACCTTGGTTTGTCAAATTCAGTATTTGATTTTTTAGATGATTTTGCGGACGT
CATGCAGGTCTTTGACGGAGAAGAAGGTCTTTACGAAGCAGAAAGCGGGATCTATGATTTGATTTTGCTGGACCTCATGC
TTCCTGAAAAAGACGGCTTCCATGTCTTGAAAGAATTGCGTGAAAAAGGCGTGACAACCCCTGTTTTGATCATGACAGCT
AAAGAAAGTCTGGATGACAAAGGACACGGATTTGAGCTGGGGGCAGACGATTACCTCACCAAACCTTTCTACCTAGAAGA
ACTCAAGATGCGGATTCAAGCTCTCTTGAAGCGCTCAGGAAAAGTGAATGAAAACACCCTTAATTATGGCAATTTGAAGG
TCAACTTATCTACCAATTCGACTTACGTGGACGGTAAGGAAGTGGAACTTCTTGGGAAGGAATTTGATCTCTTGGTCTAT
TTCCTTCAAAACCAAAATGTCATCCTTCCAAAAACACAGATTTTCGATCGCCTTTGGGGCTTTGACAGTGATACGACTAT
CTCTGTTGTTGAGGTCTATGTTTCAAAAATCCGTAAGAAATTAAAAGGTACCGATTTCGTTGAGAGCTTGCAAACATTGC
GCAGTGTGGGGTATATCTTAAAAGATGCTAACCAGAATTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2I1TVC1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

90.179

99.115

0.894
  ciaR Streptococcus pneumoniae D39

90.179

99.115

0.894
  ciaR Streptococcus pneumoniae R6

90.179

99.115

0.894
  ciaR Streptococcus pneumoniae TIGR4

90.179

99.115

0.894
  ciaR Streptococcus mutans UA159

88.393

99.115

0.876
  vicR Streptococcus mutans UA159

36.481

100

0.376
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.889

99.558

0.367
  covR Streptococcus salivarius strain HSISS4

36.123

100

0.363

Multiple sequence alignment