Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SPAF_RS04240 Genome accession   NC_017905
Coordinates   838104..839474 (+) Length   456 a.a.
NCBI ID   WP_013903377.1    Uniprot ID   I1ZL93
Organism   Streptococcus parasanguinis FW213     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 833104..844474
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPAF_RS04210 (Spaf_0808) - 833390..834100 (-) 711 WP_014713137.1 LytTR family DNA-binding domain-containing protein -
  SPAF_RS04215 (Spaf_0809) - 834207..835163 (+) 957 WP_045764003.1 ABC transporter ATP-binding protein -
  SPAF_RS04220 (Spaf_0810) - 835165..835887 (+) 723 WP_014713139.1 ABC transporter permease -
  SPAF_RS04225 (Spaf_0812) - 836040..836573 (-) 534 WP_014713140.1 BioY family transporter -
  SPAF_RS04230 (Spaf_0813) - 836780..837304 (+) 525 WP_014713141.1 hypothetical protein -
  SPAF_RS04235 (Spaf_0814) ciaR 837440..838120 (+) 681 WP_037607818.1 response regulator transcription factor Regulator
  SPAF_RS04240 (Spaf_0815) ciaH 838104..839474 (+) 1371 WP_013903377.1 HAMP domain-containing sensor histidine kinase Regulator
  SPAF_RS04245 (Spaf_0816) - 839490..839870 (+) 381 WP_003006623.1 VOC family protein -
  SPAF_RS04250 (Spaf_0817) - 839981..841363 (+) 1383 WP_014713142.1 polysaccharide deacetylase family protein -
  SPAF_RS04255 (Spaf_0818) - 841407..842492 (-) 1086 WP_014713143.1 DEAD/DEAH box helicase -
  SPAF_RS04260 (Spaf_0819) - 842489..843469 (-) 981 WP_014713144.1 Gfo/Idh/MocA family oxidoreductase -

Sequence

Protein


Download         Length: 456 a.a.        Molecular weight: 52049.53 Da        Isoelectric Point: 6.8851

>NTDB_id=51135 SPAF_RS04240 WP_013903377.1 838104..839474(+) (ciaH) [Streptococcus parasanguinis FW213]
MLTRIKKTVGEDDFSYFIRYFGLFTLIFSAMTLIIIQVMRSSLYTTVDENLKTLSKDPYSLAAIAYRDQRQSKDKDNDED
PEVMIPDHDKSEPKGDVTSNTTVVLLNRNYENLTTGNGFLNFKSVTFGRKLLNKVSQLQITNSYGKKESYRAYMTDLGLT
DDGGSDVKYAVIMTNISQLEQTSEEHESQIALVMICFWGISLFASLFLARLSVKPLLESMQKQKAFVENASHELRTPLAV
LQNRLETLFRKPEATIMESSESIASSLDEVRNMKLLTTNLLNIARRDDGLKPEIEEIEPSFFDQTFSNFEIIAEENGKFF
QGDNQVDKVICSDKTLLKQLMTILYDNALKYTDEDGEIQFEVQLKDKNLLLRALDNGPGVRDEDKKRIFDRFYRVDKART
RQKGGFGLGLSLAKQIVEAFKGTIQVKDNKPKGSIFEVKLSIKTESRKKIVHNLKK

Nucleotide


Download         Length: 1371 bp        

>NTDB_id=51135 SPAF_RS04240 WP_013903377.1 838104..839474(+) (ciaH) [Streptococcus parasanguinis FW213]
ATGCTAACCAGAATTAAGAAAACTGTCGGAGAAGATGATTTTTCCTACTTCATCCGATATTTTGGGCTCTTTACCTTGAT
ATTTTCAGCAATGACCTTGATTATCATTCAGGTTATGCGCTCGAGTCTCTATACAACTGTCGATGAGAACCTCAAGACTT
TAAGTAAGGATCCTTATTCGCTAGCGGCTATTGCTTATCGGGACCAGCGACAATCGAAAGATAAGGATAATGATGAAGAT
CCTGAGGTGATGATCCCAGATCATGATAAATCAGAACCCAAAGGAGATGTCACATCCAATACCACTGTTGTATTGCTCAA
CAGAAATTATGAAAATCTGACGACAGGCAACGGATTTTTAAACTTTAAATCTGTCACTTTTGGCCGGAAGTTGCTCAACA
AAGTTTCCCAGCTCCAAATTACAAATAGCTACGGGAAAAAAGAAAGTTACCGTGCTTATATGACAGATTTGGGATTGACT
GATGATGGGGGAAGTGACGTCAAGTATGCGGTTATCATGACCAATATTAGTCAGTTGGAGCAGACGAGTGAAGAGCACGA
AAGCCAAATCGCTCTTGTCATGATCTGCTTCTGGGGAATTTCTTTGTTTGCTAGTCTTTTCCTAGCACGTCTCAGCGTTA
AACCCCTTCTTGAGAGTATGCAAAAGCAAAAGGCTTTCGTAGAAAATGCCTCCCATGAATTGCGGACACCTTTAGCAGTC
CTCCAAAATCGCCTCGAAACGCTTTTTAGAAAACCTGAGGCAACCATCATGGAGTCAAGTGAGAGTATTGCATCCAGCTT
GGATGAAGTTCGAAATATGAAGCTCTTGACCACCAACCTTCTTAATATTGCCCGGAGGGATGATGGCTTGAAGCCAGAGA
TAGAAGAAATTGAGCCAAGCTTTTTTGATCAGACCTTCTCGAATTTTGAGATCATTGCGGAAGAAAATGGCAAATTCTTC
CAGGGGGACAATCAGGTGGACAAAGTCATTTGTTCTGATAAAACGCTCCTCAAGCAGTTGATGACCATTCTCTATGACAA
TGCCTTGAAGTACACCGACGAAGATGGTGAGATTCAGTTTGAAGTCCAGTTAAAGGACAAAAATCTTCTTTTGAGAGCAC
TGGATAATGGACCTGGTGTTCGAGACGAGGACAAGAAACGGATCTTTGATCGTTTTTACCGGGTGGATAAAGCCAGAACC
CGTCAAAAAGGTGGATTTGGTTTAGGGCTATCTTTAGCCAAACAAATTGTAGAGGCTTTTAAGGGAACCATTCAAGTTAA
AGATAATAAACCAAAAGGTTCCATCTTTGAAGTGAAATTATCCATCAAGACGGAAAGTCGTAAAAAAATCGTTCATAATT
TAAAAAAATAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(224-289)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(333-441)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I1ZL93

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

59.333

98.684

0.586
  ciaH Streptococcus pneumoniae D39

59.333

98.684

0.586
  ciaH Streptococcus pneumoniae R6

59.333

98.684

0.586
  ciaH Streptococcus pneumoniae TIGR4

59.333

98.684

0.586
  ciaH Streptococcus mutans UA159

50.227

96.491

0.485

Multiple sequence alignment