Detailed information NTG0510667

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: STAVA1121_RS05485
• Genome accession: NZ_CP065488
• Coordinates: 1020187..1020894 (-)
• Length: 235 a.a.
• NCBI ID: WP_173940375.1
• Uniprot ID: A0A2H4K9R7
• Organism: Streptococcus thermophilus strain AVA1121
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1015187..1025894

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STAVA1121_RS05460 (STAVA1121_05390)	yidA	1015538..1016347 (+)	810	WP_011226081.1	sugar-phosphatase	-
STAVA1121_RS05465 (STAVA1121_05395)	-	1016349..1017563 (+)	1215	WP_347131084.1	aminoacyltransferase	-
STAVA1121_RS05470 (STAVA1121_05400)	-	1017615..1017976 (-)	362	Protein_1021	YbaN family protein	-
STAVA1121_RS05475 (STAVA1121_05405)	vicX	1018036..1018848 (-)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
STAVA1121_RS05480 (STAVA1121_05410)	vicK	1018854..1020194 (-)	1341	WP_011227273.1	cell wall metabolism sensor histidine kinase VicK	Regulator
STAVA1121_RS05485 (STAVA1121_05415)	vicR	1020187..1020894 (-)	708	WP_173940375.1	response regulator YycF	Regulator
STAVA1121_RS05490 (STAVA1121_05420)	-	1021420..1022187 (+)	768	WP_179966655.1	amino acid ABC transporter ATP-binding protein	-
STAVA1121_RS05495 (STAVA1121_05425)	-	1022199..1023032 (+)	834	WP_002953142.1	transporter substrate-binding domain-containing protein	-
STAVA1121_RS05500 (STAVA1121_05430)	-	1023050..1023748 (+)	699	WP_065973256.1	amino acid ABC transporter permease	-
STAVA1121_RS05505 (STAVA1121_05435)	-	1023760..1024410 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
STAVA1121_RS05510 (STAVA1121_05440)	endA	1024481..1025362 (-)	882	WP_347131085.1	DNA/RNA non-specific endonuclease	Machinery gene
STAVA1121_RS05515 (STAVA1121_05445)	-	1025424..1025612 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27087.04 Da
• Isoelectric Point: 5.0130

>NTDB_id=510667 STAVA1121_RS05485 WP_173940375.1 1020187..1020894(-) (vicR) [Streptococcus thermophilus strain AVA1121]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEIAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=510667 STAVA1121_RS05485 WP_173940375.1 1020187..1020894(-) (vicR) [Streptococcus thermophilus strain AVA1121]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAATTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCACCGTGAATTTGAGTTACTCTTTCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTAACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

• Response regulator receiver domain (Response_reg) (4-113)

3D structure

• AlphaFold DB: A0A2H4K9R7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.106	100	0.851
micA	Streptococcus pneumoniae Cp1015	79.828	99.149	0.791
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.455	98.298	0.447
covR	Streptococcus salivarius strain HSISS4	44.872	99.574	0.447
scnR	Streptococcus mutans UA159	38.136	100	0.383