NTDB

Overview

Name	vicR	Type	Regulator
Locus tag	STR1_RS05490	Genome accession	NZ_CP065486
Coordinates	1055875..1056582 (-)	Length	235 a.a.
NCBI ID	WP_095559389.1	Uniprot ID	-
Organism	Streptococcus thermophilus strain R1
Function	repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1050875..1061582

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STR1_RS05470 (STR1_05535)	-	1051845..1053101 (-)	1257	WP_198362548.1	ISL3-like element ISSth1 family transposase	-
STR1_RS05475 (STR1_05540)	-	1053303..1053664 (-)	362	Protein_1035	YbaN family protein	-
STR1_RS05480 (STR1_05545)	vicX	1053724..1054536 (-)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
STR1_RS05485 (STR1_05550)	vicK	1054542..1055882 (-)	1341	WP_084830671.1	cell wall metabolism sensor histidine kinase VicK	Regulator
STR1_RS05490 (STR1_05555)	vicR	1055875..1056582 (-)	708	WP_095559389.1	response regulator YycF	Regulator
STR1_RS05495 (STR1_05560)	-	1057104..1057871 (+)	768	WP_347128973.1	amino acid ABC transporter ATP-binding protein	-
STR1_RS05500 (STR1_05565)	-	1057883..1058716 (+)	834	WP_011681208.1	transporter substrate-binding domain-containing protein	-
STR1_RS05505 (STR1_05570)	-	1058734..1059432 (+)	699	WP_014608374.1	amino acid ABC transporter permease	-
STR1_RS05510 (STR1_05575)	-	1059444..1060094 (+)	651	WP_095559390.1	amino acid ABC transporter permease	-
STR1_RS05515 (STR1_05580)	endA	1060166..1061047 (-)	882	WP_022096754.1	DNA/RNA non-specific endonuclease	Machinery gene
STR1_RS05520 (STR1_05585)	-	1061109..1061297 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

Download Length: 235 a.a. Molecular weight: 27058.98 Da Isoelectric Point: 5.0130

                                >NTDB_id=510544 STR1_RS05490 WP_095559389.1 1055875..1056582(-) (vicR) [Streptococcus thermophilus strain R1]

MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREGLEQFEAKKPDLVILDLMLPELDGLEVAKEIRKTSHTPIIMLSA

KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL

THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

Download Length: 708 bp

                                >NTDB_id=510544 STR1_RS05490 WP_095559389.1 1055875..1056582(-) (vicR) [Streptococcus thermophilus strain R1]

ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA

AGTGGTTACGGCCTTTGATGGGCGAGAAGGTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA

TGTTGCCTGAACTGGATGGTTTGGAAGTTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT

AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA

ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA

AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCCAAAAAACGTGGAAACGAAGTTGAGTTG

ACCCACCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC

CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA

CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(155-230)

Response regulator receiver domain (Response_reg)

(4-113)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
vicR	Streptococcus mutans UA159	85.106	100	0.851
micA	Streptococcus pneumoniae Cp1015	79.828	99.149	0.791
covR	Lactococcus lactis subsp. lactis strain DGCC12653	46.32	98.298	0.455
covR	Streptococcus salivarius strain HSISS4	45.726	99.574	0.455
scnR	Streptococcus mutans UA159	38.136	100	0.383

Detailed information NTG0510544