Detailed information NTG0510521

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: STR1_RS01435
• Genome accession: NZ_CP065486
• Coordinates: 270469..271368 (+)
• Length: 299 a.a.
• NCBI ID: WP_014607953.1
• Uniprot ID: A0AAN1ZWJ0
• Organism: Streptococcus thermophilus strain R1
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 265469..276368

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STR1_RS01415 (STR1_01410)	trkA	266605..267954 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
STR1_RS01420 (STR1_01415)	-	268243..268752 (+)	510	WP_011680717.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
STR1_RS01425 (STR1_01420)	-	269064..269621 (+)	558	WP_002949523.1	ECF transporter S component	-
STR1_RS01430 (STR1_01425)	-	269624..270274 (+)	651	WP_095559229.1	phosphatase PAP2 family protein	-
STR1_RS01435 (STR1_01430)	comR	270469..271368 (+)	900	WP_014607953.1	helix-turn-helix domain-containing protein	Regulator
STR1_RS01440 (STR1_01435)	-	271606..272784 (+)	1179	Protein_243	ABC transporter transmembrane domain-containing protein	-
STR1_RS01445	comA	272806..273015 (+)	210	WP_002946147.1	hypothetical protein	Regulator
STR1_RS01450 (STR1_01450)	-	273070..273638 (+)	569	Protein_245	ATP-binding cassette domain-containing protein	-
STR1_RS01455 (STR1_01455)	-	273765..274076 (+)	312	WP_095559231.1	DUF805 domain-containing protein	-
STR1_RS01460	-	274044..274328 (-)	285	WP_232085805.1	hypothetical protein	-
STR1_RS01465	-	274568..275464 (-)	897	WP_224102957.1	urease cluster protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35289.70 Da
• Isoelectric Point: 5.0061

>NTDB_id=510521 STR1_RS01435 WP_014607953.1 270469..271368(+) (comR) [Streptococcus thermophilus strain R1]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=510521 STR1_RS01435 WP_014607953.1 270469..271368(+) (comR) [Streptococcus thermophilus strain R1]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAATCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	98.997	100	0.99
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418