Detailed information NTG0510170

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ST90729_RS01475
• Genome accession: NZ_CP065480
• Coordinates: 269420..270319 (+)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus strain 90729
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 264420..275319

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST90729_RS01455 (ST90729_01450)	trkA	265555..266904 (-)	1350	WP_011225444.1	Trk system potassium transporter TrkA	-
ST90729_RS01460 (ST90729_01455)	-	267193..267702 (+)	510	WP_011680717.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
ST90729_RS01465 (ST90729_01460)	-	268015..268572 (+)	558	WP_002949523.1	ECF transporter S component	-
ST90729_RS01470 (ST90729_01465)	-	268575..269225 (+)	651	WP_022096567.1	phosphatase PAP2 family protein	-
ST90729_RS01475 (ST90729_01470)	comR	269420..270319 (+)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
ST90729_RS01480 (ST90729_01475)	-	270557..271735 (+)	1179	Protein_238	ABC transporter transmembrane domain-containing protein	-
ST90729_RS01485	comA	271757..271966 (+)	210	WP_002946147.1	hypothetical protein	Regulator
ST90729_RS01490 (ST90729_01490)	-	272021..272589 (+)	569	Protein_240	ATP-binding cassette domain-containing protein	-
ST90729_RS01495 (ST90729_01495)	-	272697..273008 (+)	312	WP_022096570.1	DUF805 domain-containing protein	-
ST90729_RS01500	-	272976..273260 (-)	285	WP_014727318.1	hypothetical protein	-
ST90729_RS01505	-	273675..273809 (-)	135	WP_259700431.1	hypothetical protein	-
ST90729_RS01510	-	274033..274404 (-)	372	WP_232510006.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=510170 ST90729_RS01475 WP_011225448.1 269420..270319(+) (comR) [Streptococcus thermophilus strain 90729]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=510170 ST90729_RS01475 WP_011225448.1 269420..270319(+) (comR) [Streptococcus thermophilus strain 90729]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGATATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421