Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   ST4134_RS03970 Genome accession   NZ_CP065478
Coordinates   744079..744240 (-) Length   53 a.a.
NCBI ID   WP_014727422.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain 4134     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 726542..766905 744079..744240 within 0


Gene organization within MGE regions


Location: 726542..766905
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4134_RS03905 (ST4134_03880) glyA 726542..727792 (+) 1251 WP_011227085.1 serine hydroxymethyltransferase -
  ST4134_RS03910 (ST4134_03885) - 727799..728776 (+) 978 WP_014608183.1 nucleoid-associated protein -
  ST4134_RS03915 (ST4134_03890) - 728778..729389 (+) 612 WP_014621429.1 lysozyme family protein -
  ST4134_RS03920 (ST4134_03895) - 729422..731161 (+) 1740 WP_011681019.1 ABC transporter ATP-binding protein -
  ST4134_RS03925 (ST4134_03900) - 731151..732899 (+) 1749 WP_011681020.1 ABC transporter ATP-binding protein -
  ST4134_RS03930 (ST4134_03905) - 733076..733207 (+) 132 WP_002885174.1 teichoic acid D-Ala incorporation-associated protein DltX -
  ST4134_RS03935 (ST4134_03910) dltA 733216..734766 (+) 1551 WP_011681022.1 D-alanine--poly(phosphoribitol) ligase subunit DltA -
  ST4134_RS03940 (ST4134_03915) dltB 734763..736010 (+) 1248 WP_014608186.1 D-alanyl-lipoteichoic acid biosynthesis protein DltB -
  ST4134_RS03945 (ST4134_03920) dltC 736028..736267 (+) 240 WP_002950439.1 D-alanine--poly(phosphoribitol) ligase subunit DltC -
  ST4134_RS03950 (ST4134_03925) dltD 736260..737528 (+) 1269 WP_011681024.1 D-alanyl-lipoteichoic acid biosynthesis protein DltD -
  ST4134_RS03955 (ST4134_03930) - 737581..738930 (-) 1350 Protein_719 IS3 family transposase -
  ST4134_RS03960 (ST4134_03935) - 739129..741765 (-) 2637 WP_014621434.1 calcium-translocating P-type ATPase, PMCA-type -
  ST4134_RS03965 (ST4134_03940) pabB 741942..743660 (-) 1719 WP_014608193.1 aminodeoxychorismate synthase component I -
  ST4134_RS03970 (ST4134_03945) prx 744079..744240 (-) 162 WP_014727422.1 hypothetical protein Regulator
  ST4134_RS03975 (ST4134_03950) - 744724..744999 (-) 276 WP_014727423.1 hypothetical protein -
  ST4134_RS03980 (ST4134_03955) - 745016..745201 (-) 186 WP_024704073.1 hypothetical protein -
  ST4134_RS03985 (ST4134_03960) - 745499..747004 (-) 1506 WP_024704074.1 phage/plasmid primase, P4 family -
  ST4134_RS03990 (ST4134_03965) - 746994..747854 (-) 861 WP_024704075.1 primase alpha helix C-terminal domain-containing protein -
  ST4134_RS03995 (ST4134_03970) - 747869..748141 (-) 273 WP_011227098.1 MerR family transcriptional regulator -
  ST4134_RS04000 (ST4134_03975) - 748384..748620 (-) 237 WP_024704076.1 hypothetical protein -
  ST4134_RS04005 (ST4134_03980) - 748634..748828 (-) 195 WP_024704077.1 hypothetical protein -
  ST4134_RS04010 (ST4134_03985) - 748832..749125 (-) 294 WP_024704078.1 hypothetical protein -
  ST4134_RS04015 (ST4134_03990) - 749364..749561 (-) 198 WP_014608200.1 helix-turn-helix transcriptional regulator -
  ST4134_RS04020 (ST4134_03995) - 749742..750236 (+) 495 WP_370869443.1 helix-turn-helix transcriptional regulator -
  ST4134_RS04025 (ST4134_04000) - 750319..751485 (+) 1167 WP_011227104.1 site-specific integrase -
  ST4134_RS04030 (ST4134_04005) - 751601..751936 (+) 336 WP_002948199.1 hypothetical protein -
  ST4134_RS04035 (ST4134_04010) metE 752265..754514 (+) 2250 WP_002950451.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
  ST4134_RS04040 (ST4134_04015) metF 754703..755578 (+) 876 WP_014621437.1 methylenetetrahydrofolate reductase [NAD(P)H] -
  ST4134_RS04045 (ST4134_04020) - 755718..757436 (-) 1719 WP_024704080.1 phospho-sugar mutase -
  ST4134_RS04050 (ST4134_04025) - 757519..758091 (-) 573 WP_011681047.1 ECF transporter S component -
  ST4134_RS04055 (ST4134_04030) coaC 758119..758664 (-) 546 WP_014608202.1 phosphopantothenoylcysteine decarboxylase -
  ST4134_RS04060 (ST4134_04035) - 758657..759340 (-) 684 WP_002948206.1 phosphopantothenate--cysteine ligase -
  ST4134_RS04065 (ST4134_04040) - 759534..761204 (+) 1671 WP_024704082.1 formate--tetrahydrofolate ligase -
  ST4134_RS04070 (ST4134_04045) - 761390..762064 (+) 675 Protein_742 response regulator transcription factor -
  ST4134_RS04075 - 762054..763473 (+) 1420 Protein_743 sensor histidine kinase -
  ST4134_RS04080 (ST4134_04070) - 763574..765144 (+) 1571 WP_087009847.1 IS3-like element ISSth1b family transposase -
  ST4134_RS04085 (ST4134_04075) - 765335..766546 (+) 1212 WP_405385512.1 ISL3 family transposase -
  ST4134_RS04090 (ST4134_04080) - 766669..766905 (+) 237 Protein_746 ABC transporter permease -

Sequence

Protein


Download         Length: 53 a.a.        Molecular weight: 6084.95 Da        Isoelectric Point: 4.2412

>NTDB_id=510064 ST4134_RS03970 WP_014727422.1 744079..744240(-) (prx) [Streptococcus thermophilus strain 4134]
MLTYDEFKEAMDKGFIKGDTVQIVRLDGEQVEPREILSLEKVSDIIKELGKDN

Nucleotide


Download         Length: 162 bp        

>NTDB_id=510064 ST4134_RS03970 WP_014727422.1 744079..744240(-) (prx) [Streptococcus thermophilus strain 4134]
ATGCTGACTTATGATGAATTTAAAGAGGCAATGGACAAGGGTTTTATTAAAGGTGATACTGTCCAGATTGTCCGATTAGA
CGGTGAACAAGTTGAGCCACGCGAAATATTGAGCTTAGAAAAGGTATCGGATATAATAAAGGAACTAGGCAAGGACAACT
AA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS8232

48.333

100

0.547
  prx Streptococcus pyogenes MGAS315

46.667

100

0.528
  prx Streptococcus pyogenes MGAS315

46.667

100

0.528
  prx Streptococcus pyogenes MGAS315

45

100

0.509
  prx Streptococcus pyogenes MGAS315

56.818

83.019

0.472
  prx Streptococcus pyogenes MGAS315

57.143

79.245

0.453
  prx Streptococcus pyogenes MGAS315

60.526

71.698

0.434