Detailed information NTG0509524

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: I5V48_RS05160
• Genome accession: NZ_CP065430
• Coordinates: 1076314..1076985 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain YZDH1
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1071314..1081985

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I5V48_RS05130 (I5V48_05130)	pstC	1071513..1072430 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
I5V48_RS05135 (I5V48_05135)	pstA	1072420..1073307 (+)	888	WP_029178759.1	phosphate ABC transporter permease PstA	-
I5V48_RS05140 (I5V48_05140)	pstB	1073332..1074135 (+)	804	WP_174850197.1	phosphate ABC transporter ATP-binding protein PstB	-
I5V48_RS05145 (I5V48_05145)	pstB	1074147..1074905 (+)	759	WP_043024749.1	phosphate ABC transporter ATP-binding protein PstB	-
I5V48_RS05150 (I5V48_05150)	phoU	1074934..1075590 (+)	657	WP_043033622.1	phosphate signaling complex protein PhoU	-
I5V48_RS05155 (I5V48_05155)	-	1075739..1076119 (+)	381	WP_043025691.1	hypothetical protein	-
I5V48_RS05160 (I5V48_05160)	ciaR	1076314..1076985 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
I5V48_RS05165 (I5V48_05165)	ciaH	1076978..1078357 (+)	1380	WP_043025694.1	sensor histidine kinase	Regulator
I5V48_RS05170 (I5V48_05170)	-	1078458..1079687 (+)	1230	WP_197315161.1	transglutaminase domain-containing protein	-
I5V48_RS05175 (I5V48_05175)	rpsT	1079903..1080151 (-)	249	WP_061630527.1	30S ribosomal protein S20	-
I5V48_RS05180 (I5V48_05180)	coaA	1080210..1081130 (-)	921	WP_197315162.1	type I pantothenate kinase	-
I5V48_RS05185 (I5V48_05185)	-	1081239..1081829 (+)	591	WP_074411948.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=509524 I5V48_RS05160 WP_014637852.1 1076314..1076985(+) (ciaR) [Streptococcus suis strain YZDH1]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=509524 I5V48_RS05160 WP_014637852.1 1076314..1076985(+) (ciaR) [Streptococcus suis strain YZDH1]
ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAAGAAGGAATCTATGAAGCGGAAACTGGTGTGTACGACTTAATTTTATTAGATTTAATGT
TACCTGAAAAAGACGGCTTTCAAGTCTTGAAAGAGTTACGTGAAAAAGGTGTTACAACTCCTGTCTTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGCGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGATGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTGGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCCAAAACTCAAATTTTTGATAGAATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTATATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368