Detailed information NTG0506848

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: VB13_RS01775
• Genome accession: NZ_CP077685
• Coordinates: 334976..335566 (+)
• Length: 196 a.a.
• NCBI ID: WP_002985850.1
• Uniprot ID: A0A9X9QW05
• Organism: Streptococcus pyogenes strain M49 591
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 329976..340566

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VB13_RS01760 (VB13_01825)	-	330788..332233 (-)	1446	WP_002990934.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-
VB13_RS01765 (VB13_01830)	-	332321..333955 (+)	1635	WP_012560472.1	polysaccharide biosynthesis protein	-
VB13_RS01770 (VB13_01835)	upp	334123..334752 (+)	630	WP_219050313.1	uracil phosphoribosyltransferase	-
VB13_RS01775 (VB13_01840)	clpP	334976..335566 (+)	591	WP_002985850.1	ATP-dependent Clp protease proteolytic subunit	Regulator
VB13_RS01780 (VB13_01845)	-	336058..336333 (+)	276	WP_002985847.1	YlbG family protein	-
VB13_RS01785 (VB13_01850)	tmk	336582..337217 (+)	636	WP_009880727.1	dTMP kinase	-
VB13_RS01790 (VB13_01855)	-	337235..338110 (+)	876	WP_009880726.1	DNA polymerase III subunit delta'	-
VB13_RS08830	-	338235..338369 (+)	135	WP_002990910.1	hypothetical protein	-
VB13_RS01800 (VB13_01860)	yabA	338774..339097 (+)	324	WP_002985838.1	DNA replication initiation control protein YabA	-
VB13_RS01805 (VB13_01865)	rsmI	339102..339965 (+)	864	WP_012560474.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
VB13_RS01810 (VB13_01870)	-	339992..340384 (+)	393	WP_002985833.1	DUF5684 domain-containing protein	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21648.88 Da
• Isoelectric Point: 5.2834

>NTDB_id=506848 VB13_RS01775 WP_002985850.1 334976..335566(+) (clpP) [Streptococcus pyogenes strain M49 591]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK

Nucleotide

• Length: 591 bp

>NTDB_id=506848 VB13_RS01775 WP_002985850.1 334976..335566(+) (clpP) [Streptococcus pyogenes strain M49 591]
ATGATTCCTGTTGTTATTGAACAAACTAGCCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACGAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCCGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCACAAAATGCTGGGAAA
ACGATTAAACAAATTCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA

Domains

Predicted by InterProScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: A0A9X9QW05

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus pyogenes MGAS315	100	100	1
clpP	Streptococcus pyogenes JRS4	100	100	1
clpP	Streptococcus mutans UA159	90.816	100	0.908
clpP	Streptococcus pneumoniae Rx1	90.769	99.49	0.903
clpP	Streptococcus pneumoniae D39	90.769	99.49	0.903
clpP	Streptococcus pneumoniae R6	90.769	99.49	0.903
clpP	Streptococcus pneumoniae TIGR4	90.769	99.49	0.903
clpP	Streptococcus thermophilus LMG 18311	89.796	100	0.898
clpP	Streptococcus thermophilus LMD-9	89.796	100	0.898
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	86.224	100	0.862
clpP	Lactococcus lactis subsp. cremoris KW2	85.714	100	0.857
clpP	Bacillus subtilis subsp. subtilis str. 168	57.143	100	0.571
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	56.995	98.469	0.561