Detailed information NTG0049584

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: SSGZ1_RS04965
• Genome accession: NC_017617
• Coordinates: 1010112..1010783 (-)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis GZ1
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1005112..1015783

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SSGZ1_RS04940 (SSGZ1_0958)	-	1005222..1005812 (-)	591	WP_014635990.1	class I SAM-dependent methyltransferase	-
SSGZ1_RS04945 (SSGZ1_0959)	coaA	1005921..1006841 (+)	921	WP_002935283.1	type I pantothenate kinase	-
SSGZ1_RS04950 (SSGZ1_0960)	rpsT	1006900..1007148 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
SSGZ1_RS04955 (SSGZ1_0961)	-	1007411..1008640 (-)	1230	WP_024389538.1	transglutaminase domain-containing protein	-
SSGZ1_RS04960 (SSGZ1_0962)	ciaH	1008740..1010119 (-)	1380	WP_014635993.1	sensor histidine kinase	Regulator
SSGZ1_RS04965 (SSGZ1_0963)	ciaR	1010112..1010783 (-)	672	WP_014637852.1	response regulator transcription factor	Regulator
SSGZ1_RS04970 (SSGZ1_0964)	-	1010977..1011324 (-)	348	WP_014635995.1	hypothetical protein	-
SSGZ1_RS04975 (SSGZ1_0965)	phoU	1011490..1012146 (-)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
SSGZ1_RS04980 (SSGZ1_0966)	pstB	1012175..1012933 (-)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
SSGZ1_RS04985 (SSGZ1_0967)	pstB	1012945..1013748 (-)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
SSGZ1_RS04990 (SSGZ1_0968)	pstA	1013773..1014660 (-)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
SSGZ1_RS04995 (SSGZ1_0969)	pstC	1014650..1015567 (-)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=49584 SSGZ1_RS04965 WP_014637852.1 1010112..1010783(-) (ciaR) [Streptococcus suis GZ1]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=49584 SSGZ1_RS04965 WP_014637852.1 1010112..1010783(-) (ciaR) [Streptococcus suis GZ1]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTGGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368