Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   SPYALAB49_RS05685 Genome accession   NC_017596
Coordinates   1131589..1131771 (-) Length   60 a.a.
NCBI ID   WP_014635572.1    Uniprot ID   A0A8B6J386
Organism   Streptococcus pyogenes Alab49     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1131589..1157879 1131589..1131771 within 0


Gene organization within MGE regions


Location: 1131589..1157879
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYALAB49_RS05685 (SPYALAB49_001167) prx 1131589..1131771 (-) 183 WP_014635572.1 hypothetical protein Regulator
  SPYALAB49_RS05690 (SPYALAB49_001168) mf2 1132011..1132769 (+) 759 WP_014635573.1 DNase Mf2 -
  SPYALAB49_RS05695 (SPYALAB49_001169) speC 1132880..1133587 (+) 708 WP_002985327.1 streptococcal pyrogenic exotoxin SpeC -
  SPYALAB49_RS05700 (SPYALAB49_001170) - 1133656..1134873 (-) 1218 WP_014635574.1 peptidoglycan amidohydrolase family protein -
  SPYALAB49_RS05710 (SPYALAB49_001171) - 1134992..1135219 (-) 228 WP_003058873.1 phage holin -
  SPYALAB49_RS05715 (SPYALAB49_001172) - 1135216..1135488 (-) 273 WP_011017397.1 hypothetical protein -
  SPYALAB49_RS05720 (SPYALAB49_001173) - 1135500..1136132 (-) 633 WP_014635575.1 hypothetical protein -
  SPYALAB49_RS05725 (SPYALAB49_001174) - 1136135..1136563 (-) 429 WP_011528780.1 DUF1617 family protein -
  SPYALAB49_RS05730 (SPYALAB49_001175) - 1136572..1138353 (-) 1782 WP_011528781.1 gp58-like family protein -
  SPYALAB49_RS05735 (SPYALAB49_001176) hylP 1138368..1139483 (-) 1116 WP_011528782.1 hyaluronoglucosaminidase -
  SPYALAB49_RS05740 (SPYALAB49_001177) - 1139480..1141456 (-) 1977 WP_028797149.1 phage tail spike protein -
  SPYALAB49_RS05745 (SPYALAB49_001178) - 1141438..1142133 (-) 696 WP_002992579.1 hypothetical protein -
  SPYALAB49_RS05750 (SPYALAB49_001179) - 1142130..1144487 (-) 2358 WP_011528784.1 hypothetical protein -
  SPYALAB49_RS05755 (SPYALAB49_001180) - 1144487..1144858 (-) 372 WP_011528785.1 DUF5361 domain-containing protein -
  SPYALAB49_RS05760 (SPYALAB49_001181) - 1144873..1145136 (-) 264 WP_003047548.1 hypothetical protein -
  SPYALAB49_RS05765 (SPYALAB49_001182) - 1145147..1145725 (-) 579 WP_014635577.1 hypothetical protein -
  SPYALAB49_RS05770 (SPYALAB49_001183) - 1145737..1146072 (-) 336 WP_011528787.1 hypothetical protein -
  SPYALAB49_RS05775 (SPYALAB49_001184) - 1146317..1146568 (-) 252 WP_011054692.1 hypothetical protein -
  SPYALAB49_RS09800 (SPYALAB49_001185) - 1146565..1146720 (-) 156 WP_011054693.1 hypothetical protein -
  SPYALAB49_RS05780 (SPYALAB49_001186) - 1146717..1147034 (-) 318 WP_011054694.1 DUF1372 family protein -
  SPYALAB49_RS05785 (SPYALAB49_001187) - 1147070..1147582 (-) 513 WP_011054695.1 hypothetical protein -
  SPYALAB49_RS05790 (SPYALAB49_001188) - 1147579..1147911 (-) 333 WP_011184741.1 hypothetical protein -
  SPYALAB49_RS05795 (SPYALAB49_001189) - 1147922..1149268 (-) 1347 WP_011054697.1 PcfJ domain-containing protein -
  SPYALAB49_RS05800 (SPYALAB49_001190) - 1149265..1149660 (-) 396 WP_011054698.1 Cas9 inhibitor AcrIIA9 family protein -
  SPYALAB49_RS05805 (SPYALAB49_001191) - 1150025..1150822 (-) 798 WP_011054699.1 PD-(D/E)XK nuclease-like domain-containing protein -
  SPYALAB49_RS05810 (SPYALAB49_001192) - 1150815..1151015 (-) 201 WP_000594115.1 hypothetical protein -
  SPYALAB49_RS05815 (SPYALAB49_001193) - 1151012..1151938 (-) 927 WP_011054700.1 recombinase RecT -
  SPYALAB49_RS05820 (SPYALAB49_001194) - 1151941..1152270 (-) 330 WP_011528796.1 hypothetical protein -
  SPYALAB49_RS05825 (SPYALAB49_001195) - 1152326..1152532 (-) 207 WP_002988357.1 hypothetical protein -
  SPYALAB49_RS09805 (SPYALAB49_001196) - 1152541..1152681 (-) 141 WP_002988354.1 hypothetical protein -
  SPYALAB49_RS05830 (SPYALAB49_001197) - 1152678..1152911 (-) 234 WP_010922205.1 hypothetical protein -
  SPYALAB49_RS05835 (SPYALAB49_001198) - 1152892..1153278 (-) 387 WP_011017564.1 DnaD domain-containing protein -
  SPYALAB49_RS09970 - 1153419..1153688 (-) 270 WP_011106700.1 replication protein -
  SPYALAB49_RS05845 (SPYALAB49_001199) - 1153782..1153967 (-) 186 WP_010922477.1 hypothetical protein -
  SPYALAB49_RS05850 (SPYALAB49_001200) - 1153969..1154280 (-) 312 WP_010922478.1 excisionase -
  SPYALAB49_RS05855 (SPYALAB49_001201) - 1154550..1154762 (-) 213 WP_010922479.1 helix-turn-helix domain-containing protein -
  SPYALAB49_RS05860 (SPYALAB49_001202) - 1154964..1155719 (+) 756 WP_010922480.1 XRE family transcriptional regulator -
  SPYALAB49_RS05865 (SPYALAB49_001203) - 1155731..1156249 (+) 519 WP_011528799.1 HIRAN domain-containing protein -
  SPYALAB49_RS05870 (SPYALAB49_001204) - 1156373..1157515 (+) 1143 WP_003051793.1 site-specific integrase -
  SPYALAB49_RS05875 (SPYALAB49_001205) - 1157604..1157879 (-) 276 WP_002983920.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 7067.01 Da        Isoelectric Point: 4.1079

>NTDB_id=49540 SPYALAB49_RS05685 WP_014635572.1 1131589..1131771(-) (prx) [Streptococcus pyogenes Alab49]
MLTYDEFKQAIDNGYITGDTVMIVRKNGQIFDYVLPNEKIRDWEVVTDEKVEEVLVELSR

Nucleotide


Download         Length: 183 bp        

>NTDB_id=49540 SPYALAB49_RS05685 WP_014635572.1 1131589..1131771(-) (prx) [Streptococcus pyogenes Alab49]
ATGCTAACATACGACGAATTTAAGCAAGCAATTGACAACGGATATATCACAGGAGACACAGTTATGATCGTGCGTAAAAA
CGGACAGATTTTTGATTATGTTTTGCCGAATGAGAAGATAAGAGATTGGGAGGTTGTGACAGACGAAAAAGTGGAAGAGG
TGCTGGTGGAGCTTTCGAGATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A8B6J386

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

90

100

0.9
  prx Streptococcus pyogenes MGAS8232

85

100

0.85
  prx Streptococcus pyogenes MGAS315

80

100

0.8
  prx Streptococcus pyogenes MGAS315

73.333

100

0.733
  prx Streptococcus pyogenes MGAS315

90.244

68.333

0.617
  prx Streptococcus pyogenes MGAS315

85.714

70

0.6
  prx Streptococcus pyogenes MGAS315

78.571

70

0.55

Multiple sequence alignment