Detailed information NTG0049472

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: SALIVA_RS06055
• Genome accession: NC_017595
• Coordinates: 1261540..1262214 (-)
• Length: 224 a.a.
• NCBI ID: WP_014634601.1
• Uniprot ID: -
• Organism: Streptococcus salivarius JIM8777
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1256540..1267214

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SALIVA_RS06030 (SALIVA_1235)	-	1256854..1258131 (-)	1278	WP_014634600.1	pyrimidine-nucleoside phosphorylase	-
SALIVA_RS06035 (SALIVA_1236)	-	1258128..1258718 (-)	591	WP_014633038.1	class I SAM-dependent methyltransferase	-
SALIVA_RS06040 (SALIVA_1237)	coaA	1258831..1259751 (+)	921	WP_013990467.1	type I pantothenate kinase	-
SALIVA_RS06045 (SALIVA_1238)	rpsT	1259821..1260057 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
SALIVA_RS06050 (SALIVA_1239)	ciaH	1260135..1261550 (-)	1416	WP_013990466.1	cell wall metabolism sensor histidine kinase WalK	Regulator
SALIVA_RS06055 (SALIVA_1240)	ciaR	1261540..1262214 (-)	675	WP_014634601.1	response regulator transcription factor	Regulator
SALIVA_RS06060 (SALIVA_1241)	-	1262414..1264084 (-)	1671	WP_014634602.1	formate--tetrahydrofolate ligase	-
SALIVA_RS06065 (SALIVA_1242)	-	1264279..1264962 (+)	684	WP_014634603.1	phosphopantothenate--cysteine ligase	-
SALIVA_RS06070 (SALIVA_1243)	coaC	1264955..1265500 (+)	546	WP_014634604.1	phosphopantothenoylcysteine decarboxylase	-
SALIVA_RS06075 (SALIVA_1244)	-	1265529..1266101 (+)	573	WP_014634605.1	ECF transporter S component	-
SALIVA_RS06080 (SALIVA_1245)	-	1266168..1266728 (+)	561	WP_004182060.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25376.04 Da
• Isoelectric Point: 4.2845

>NTDB_id=49472 SALIVA_RS06055 WP_014634601.1 1261540..1262214(-) (ciaR) [Streptococcus salivarius JIM8777]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFVANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=49472 SALIVA_RS06055 WP_014634601.1 1261540..1262214(-) (ciaR) [Streptococcus salivarius JIM8777]
ATGATTAAAATATTACTAGTTGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGACGT
TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACTTAATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGATAAAGGTGTAACAACTCCTGTACTTATCATGACTGCT
AAAGAAAGTCTAGACGATAAGGGACATGGTTTTGAACTTGGTGCGGATGACTATCTAACCAAACCTTTCTACTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTCGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACTACGGT
ATCAGTTGTTGAAGTATACGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGATTTTGTTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	86.161	100	0.862
ciaR	Streptococcus pneumoniae D39	86.547	99.554	0.862
ciaR	Streptococcus pneumoniae R6	86.547	99.554	0.862
ciaR	Streptococcus pneumoniae TIGR4	86.547	99.554	0.862
ciaR	Streptococcus pneumoniae Rx1	86.547	99.554	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.767	100	0.393
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362