Detailed information NTG0049399

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: SSAL_RS04205
• Genome accession: NC_017594
• Coordinates: 942080..942754 (+)
• Length: 224 a.a.
• NCBI ID: WP_004182019.1
• Uniprot ID: A0AAW6D9L9
• Organism: Streptococcus salivarius 57.I
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 937080..947754

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SSAL_RS04180 (Ssal_00936)	-	937568..938128 (-)	561	WP_004182060.1	ECF transporter S component	-
SSAL_RS04185 (Ssal_00938)	-	938195..938767 (-)	573	WP_004182105.1	ECF transporter S component	-
SSAL_RS04190 (Ssal_00939)	coaC	938796..939341 (-)	546	WP_014633033.1	phosphopantothenoylcysteine decarboxylase	-
SSAL_RS04195 (Ssal_00940)	-	939334..940017 (-)	684	WP_014633034.1	phosphopantothenate--cysteine ligase	-
SSAL_RS04200 (Ssal_00941)	-	940211..941881 (+)	1671	WP_004182072.1	formate--tetrahydrofolate ligase	-
SSAL_RS04205 (Ssal_00942)	ciaR	942080..942754 (+)	675	WP_004182019.1	response regulator transcription factor	Regulator
SSAL_RS04210 (Ssal_00943)	ciaH	942744..944159 (+)	1416	WP_045001673.1	HAMP domain-containing sensor histidine kinase	Regulator
SSAL_RS04215 (Ssal_00944)	rpsT	944243..944479 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
SSAL_RS04220 (Ssal_00945)	coaA	944549..945469 (-)	921	WP_014633037.1	type I pantothenate kinase	-
SSAL_RS04225 (Ssal_00946)	-	945582..946172 (+)	591	WP_014633038.1	class I SAM-dependent methyltransferase	-
SSAL_RS04230 (Ssal_00947)	-	946169..947458 (+)	1290	WP_014633039.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25392.04 Da
• Isoelectric Point: 4.2897

>NTDB_id=49399 SSAL_RS04205 WP_004182019.1 942080..942754(+) (ciaR) [Streptococcus salivarius 57.I]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=49399 SSAL_RS04205 WP_004182019.1 942080..942754(+) (ciaR) [Streptococcus salivarius 57.I]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACTTAATGT
TGCCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGAAAAGGGTGTAACAACCCCTGTACTAATCATGACGGCT
AAGGAAAGTCTAGACGATAAGGGACACGGCTTTGAACTGGGTGCAGATGACTACCTAACTAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAATACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGATCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTAGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTACCAATCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362