Detailed information NTG0049313

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: SPNINV200_RS04660
• Genome accession: NC_017593
• Coordinates: 880443..881081 (+)
• Length: 212 a.a.
• NCBI ID: WP_000387326.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae INV200
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 875443..886081

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPNINV200_RS04630 (SPNINV200_08630)	pyrH	876169..876906 (+)	738	WP_000002996.1	UMP kinase	-
SPNINV200_RS04635 (SPNINV200_08640)	frr	876915..877472 (+)	558	WP_001262225.1	ribosome recycling factor	-
SPNINV200_RS04640 (SPNINV200_08650)	cvfB	877532..878386 (+)	855	WP_001095445.1	RNA-binding virulence regulatory protein CvfB	-
SPNINV200_RS04645 (SPNINV200_08660)	-	878395..878610 (+)	216	WP_001232089.1	YozE family protein	-
SPNINV200_RS04650 (SPNINV200_08670)	-	878696..879700 (+)	1005	WP_000658197.1	PhoH family protein	-
SPNINV200_RS04655 (SPNINV200_08680)	-	879807..880376 (+)	570	WP_000443729.1	GNAT family N-acetyltransferase	-
SPNINV200_RS04660 (SPNINV200_08690)	comEA/celA/cilE	880443..881081 (+)	639	WP_000387326.1	helix-hairpin-helix domain-containing protein	Machinery gene
SPNINV200_RS04665 (SPNINV200_08700)	-	881065..882741 (+)	1677	Protein_883	ComEC/Rec2 family competence protein	-
SPNINV200_RS04670 (SPNINV200_08710)	-	882873..883508 (+)	636	WP_000207454.1	CpXC domain-containing protein	-
SPNINV200_RS04675 (SPNINV200_08720)	-	883637..884749 (+)	1113	WP_001842570.1	recombinase family protein	-
SPNINV200_RS04680 (SPNINV200_08730)	-	884764..885180 (+)	417	WP_001211122.1	hypothetical protein	-
SPNINV200_RS13135	-	885427..885507 (+)	81	WP_231840583.1	DUF1643 domain-containing protein	-

Sequence

Protein

• Length: 212 a.a.
• Molecular weight: 22619.80 Da
• Isoelectric Point: 6.5045

>NTDB_id=49313 SPNINV200_RS04660 WP_000387326.1 880443..881081(+) (comEA/celA/cilE) [Streptococcus pneumoniae INV200]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPHTPVKETNLQAEVAAVSKDSSTEKEVKEEPVEQDLITVDVKGAVKS
PGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEESASQQAGSGTASSTSKEKKVNLNKASLEE
LKQVKGLGGKRAQDIIDHRESNGKFKSVDELKKVSGIGAKTIEKLKDYVAVD

Nucleotide

• Length: 639 bp

>NTDB_id=49313 SPNINV200_RS04660 WP_000387326.1 880443..881081(+) (comEA/celA/cilE) [Streptococcus pneumoniae INV200]
ATGGAAGCAATTATCGAGAAAATAAAAGAGTATAAAATCATTGTCATCTGTACTGGTCTGGGCCTGCTTGTTGGCGGATT
TTTCCTACTAAAGCCAGCTCCACACACACCTGTCAAAGAAACGAATTTGCAGGCAGAAGTTGCAGCTGTTTCCAAGGATT
CATCGACCGAAAAGGAAGTGAAGGAAGAACCGGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGTGCTGTCAAATCG
CCAGGAATTTATGACTTGCCCGTAGGTAGTCGGGTCAATGATGCCGTTCAAAAGGCGGGTGGCTTGACAGAGCAAGCAGA
CAGCAAGTCGCTTAATCTAGCTCAGAAAGTTAGTGACGAGGCTCTGGTTTACGTTCCCACTAAGGGAGAAGAATCAGCTA
GTCAGCAGGCAGGTTCTGGGACGGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCCAGTCTGGAAGAG
CTTAAACAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGTCAAATGGGAAATTCAAGTC
AGTAGACGAGCTCAAAAAGGTCTCTGGCATTGGTGCCAAGACTATAGAAAAGTTAAAAGACTATGTTGCAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (72-122)

• Helix-hairpin-helix motif (HHH_3) (147-209)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	93.981	100	0.958
comEA/celA/cilE	Streptococcus mitis NCTC 12261	93.519	100	0.953
comEA/celA/cilE	Streptococcus pneumoniae Rx1	91.204	100	0.929
comEA/celA/cilE	Streptococcus pneumoniae D39	91.204	100	0.929
comEA/celA/cilE	Streptococcus pneumoniae R6	91.204	100	0.929
comEA/celA/cilE	Streptococcus mitis SK321	90.741	100	0.925
comEA	Lactococcus lactis subsp. cremoris KW2	42.081	100	0.439
comEA	Streptococcus thermophilus LMD-9	39.738	100	0.429
comEA	Latilactobacillus sakei subsp. sakei 23K	34.498	100	0.373