Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I872_RS04145 Genome accession   NC_021175
Coordinates   860172..860846 (+) Length   224 a.a.
NCBI ID   WP_015604895.1    Uniprot ID   A0ABM5NJP5
Organism   Streptococcus cristatus AS 1.3089     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 855172..865846
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I872_RS04125 (I872_04125) - 855829..856125 (+) 297 WP_015604891.1 hypothetical protein -
  I872_RS04130 (I872_04130) - 856134..856454 (+) 321 WP_015604892.1 hypothetical protein -
  I872_RS04135 (I872_04135) - 856701..859244 (+) 2544 WP_015604893.1 M1 family metallopeptidase -
  I872_RS04140 (I872_04140) - 859629..860051 (+) 423 WP_041826796.1 hypothetical protein -
  I872_RS04145 (I872_04145) ciaR 860172..860846 (+) 675 WP_015604895.1 response regulator transcription factor Regulator
  I872_RS04150 (I872_04150) ciaH 860836..862200 (+) 1365 WP_015604896.1 sensor histidine kinase Regulator
  I872_RS04155 (I872_04155) - 862275..862661 (+) 387 WP_015604897.1 VOC family protein -
  I872_RS04160 (I872_04160) - 862750..864147 (+) 1398 WP_015604898.1 polysaccharide deacetylase family protein -
  I872_RS04165 (I872_04165) - 864229..865317 (-) 1089 WP_015604899.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25299.00 Da        Isoelectric Point: 4.2907

>NTDB_id=48512 I872_RS04145 WP_015604895.1 860172..860846(+) (ciaR) [Streptococcus cristatus AS 1.3089]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVAVNLSTNSTLVDGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTAFANNLQTLRSVGYILKNAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=48512 I872_RS04145 WP_015604895.1 860172..860846(+) (ciaR) [Streptococcus cristatus AS 1.3089]
ATGATTAAGATTCTATTAGTGGAGGATGACCTCGGTCTGTCAAACTCAGTATTTGATTTTTTAGATGATTTTGCAGATGT
TATGCAGGTCTTTGATGGCGAAGAAGGACTATACGAGGCAGAAAGTGGCGTTTATGACCTGATTTTGCTGGACTTGATGT
TGCCTGAAAAGGACGGCTTCCAAGTGCTTAAAGAATTGCGTGAAAAAGGGGTCACCACTCCTGTCCTCATCATGACTGCC
AAGGAAAGTATCGATGATAAAGGCCATGGTTTTGAACTCGGTGCTGACGATTACCTGACTAAGCCTTTTTATCTGGAAGA
GCTTAAAATGCGGATTCAGGCCTTGCTCAAACGCTCTGGTAAGTTTAATGAAAATACCCTGTCCTATGGCGATGTGGCGG
TCAATCTTTCGACCAATTCGACCTTGGTAGACGGAAAAGAAGTGGAACTGCTGGGCAAAGAGTTTGATCTGTTGGTCTAC
TTCCTTCAGAATCAAAATGTCATTTTGCCCAAGACTCAGATCTTCGATCGTTTGTGGGGCTTTGACAGCGATACGACGAT
TTCTGTGGTGGAAGTCTATGTATCTAAGATTCGGAAAAAATTGAAAGGAACGGCTTTTGCGAATAATCTTCAAACCCTTC
GCAGTGTCGGTTACATTTTAAAGAATGCTGAATAA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

90.625

100

0.906
  ciaR Streptococcus pneumoniae D39

90.625

100

0.906
  ciaR Streptococcus pneumoniae R6

90.625

100

0.906
  ciaR Streptococcus pneumoniae TIGR4

90.625

100

0.906
  ciaR Streptococcus mutans UA159

88.789

99.554

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.381

100

0.397
  vicR Streptococcus mutans UA159

35.897

100

0.375
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment