Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   SPN034183_RS10245 Genome accession   NC_021028
Coordinates   1879518..1879958 (-) Length   146 a.a.
NCBI ID   WP_001206586.1    Uniprot ID   -
Organism   Streptococcus pneumoniae SPN034183     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1874518..1884958
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPN034183_RS10215 (SPN034183_18420) - 1874828..1875703 (+) 876 WP_000669493.1 substrate-binding domain-containing protein -
  SPN034183_RS10220 (SPN034183_18430) pstC 1875821..1876684 (+) 864 WP_000165889.1 phosphate ABC transporter permease subunit PstC -
  SPN034183_RS10225 (SPN034183_18440) pstA 1876677..1877492 (+) 816 WP_000049768.1 phosphate ABC transporter permease PstA -
  SPN034183_RS10230 (SPN034183_18450) pstB 1877494..1878246 (+) 753 WP_000536449.1 phosphate ABC transporter ATP-binding protein PstB -
  SPN034183_RS10235 (SPN034183_18460) phoU 1878261..1878911 (+) 651 WP_001245784.1 phosphate signaling complex protein PhoU -
  SPN034183_RS10240 (SPN034183_18470) - 1878973..1879404 (+) 432 Protein_1918 transposase -
  SPN034183_RS10245 (SPN034183_18480) comR 1879518..1879958 (-) 441 WP_001206586.1 helix-turn-helix transcriptional regulator Regulator
  SPN034183_RS10250 (SPN034183_18490) - 1880170..1881186 (+) 1017 WP_000415109.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
  SPN034183_RS10255 (SPN034183_18500) galU 1881208..1882107 (+) 900 WP_000202230.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
  SPN034183_RS10260 (SPN034183_18510) - 1882174..1882851 (-) 678 WP_000658498.1 rhomboid family intramembrane serine protease -
  SPN034183_RS10265 (SPN034183_18520) - 1882835..1883374 (-) 540 WP_000834326.1 5-formyltetrahydrofolate cyclo-ligase -
  SPN034183_RS10270 (SPN034183_18530) - 1883386..1884516 (-) 1131 WP_000885107.1 N-acetyldiaminopimelate deacetylase -

Sequence

Protein


Download         Length: 146 a.a.        Molecular weight: 17630.36 Da        Isoelectric Point: 5.1703

>NTDB_id=48225 SPN034183_RS10245 WP_001206586.1 1879518..1879958(-) (comR) [Streptococcus pneumoniae SPN034183]
MREFGEKIKRLRLAKKISRSEFCGDESELSIRQLIRIENGESRPTLTKLKYIAERLGVEDYKLMPSYIELDKEYLELKYF
LMRTPTYEDETIAQKKESVFAKIFEEYYDRLPEEERFIIPNYSYLALTNYTVQKLPEKLVEILSFW

Nucleotide


Download         Length: 441 bp        

>NTDB_id=48225 SPN034183_RS10245 WP_001206586.1 1879518..1879958(-) (comR) [Streptococcus pneumoniae SPN034183]
TTGCGAGAGTTTGGCGAAAAAATTAAAAGATTACGTTTGGCTAAAAAAATCAGTCGTTCAGAATTTTGTGGTGATGAGTC
TGAATTAAGTATCCGTCAATTAATTAGAATTGAAAATGGAGAATCCAGACCAACACTAACAAAGTTAAAATATATCGCTG
AACGTTTGGGGGTTGAAGATTACAAGTTGATGCCAAGTTATATAGAGTTGGATAAGGAATACCTAGAATTGAAGTATTTC
TTGATGAGGACTCCTACATACGAAGATGAAACTATCGCCCAAAAGAAAGAGAGTGTTTTTGCTAAGATTTTTGAAGAGTA
TTATGATAGGCTACCTGAGGAAGAAAGATTTATCATCCCAAATTATTCATATCTGGCACTAACGAACTACACAGTTCAAA
AATTACCAGAAAAGCTAGTTGAAATACTGTCCTTCTGGTGA

Domains

Predicted by InterProScan.

ComR tetratricopeptide (ComR_TPR)

(72-119)

Helix-turn-helix (HTH_3)

(8-59)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

54.167

82.192

0.445
  comR Streptococcus pyogenes MGAS315

52.5

82.192

0.432
  comR Streptococcus mutans UA159

52.5

82.192

0.432
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

53.636

75.342

0.404
  comR Streptococcus suis 05ZYH33

48.305

80.822

0.39
  comR Streptococcus suis P1/7

48.305

80.822

0.39
  comR Streptococcus suis D9

47.458

80.822

0.384
  comR/comR1 Streptococcus sobrinus strain NIDR 6715-7

46.491

78.082

0.363

Multiple sequence alignment