Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   IB938_RS06335 Genome accession   NZ_CP061131
Coordinates   1242472..1242654 (-) Length   60 a.a.
NCBI ID   WP_011528776.1    Uniprot ID   A0A660A5W9
Organism   Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1242472..1278151 1242472..1242654 within 0


Gene organization within MGE regions


Location: 1242472..1278151
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IB938_RS06335 (IB938_06335) prx 1242472..1242654 (-) 183 WP_011528776.1 hypothetical protein Regulator
  IB938_RS06340 (IB938_06340) entC3 1242767..1243549 (-) 783 WP_002988472.1 enterotoxin type C3 EntC3 -
  IB938_RS06345 (IB938_06345) - 1243797..1244921 (-) 1125 WP_002988467.1 Fic family protein -
  IB938_RS06350 (IB938_06350) - 1245057..1246274 (-) 1218 WP_011528778.1 peptidoglycan amidohydrolase family protein -
  IB938_RS06355 (IB938_06355) - 1246393..1246620 (-) 228 WP_003058873.1 phage holin -
  IB938_RS06360 (IB938_06360) - 1246617..1246889 (-) 273 WP_011017397.1 hypothetical protein -
  IB938_RS06365 (IB938_06365) - 1246901..1247533 (-) 633 WP_011528779.1 hypothetical protein -
  IB938_RS06370 (IB938_06370) - 1247536..1247964 (-) 429 WP_011528780.1 DUF1617 family protein -
  IB938_RS06375 (IB938_06375) - 1247973..1249754 (-) 1782 WP_011528781.1 gp58-like family protein -
  IB938_RS06380 (IB938_06380) hylP 1249769..1250884 (-) 1116 WP_011528782.1 hyaluronoglucosaminidase -
  IB938_RS06385 (IB938_06385) - 1250881..1252857 (-) 1977 WP_047235223.1 phage tail spike protein -
  IB938_RS06390 (IB938_06390) - 1252839..1253534 (-) 696 WP_047235222.1 hypothetical protein -
  IB938_RS06395 (IB938_06395) - 1253531..1255888 (-) 2358 WP_011528784.1 hypothetical protein -
  IB938_RS06400 (IB938_06400) - 1255888..1256259 (-) 372 WP_011528785.1 DUF5361 domain-containing protein -
  IB938_RS06405 (IB938_06405) - 1256274..1256537 (-) 264 WP_003047548.1 hypothetical protein -
  IB938_RS06410 (IB938_06410) - 1256548..1257126 (-) 579 WP_014635577.1 hypothetical protein -
  IB938_RS06415 (IB938_06415) - 1257138..1257473 (-) 336 WP_011528787.1 hypothetical protein -
  IB938_RS06420 (IB938_06420) - 1257474..1257710 (-) 237 WP_000032787.1 hypothetical protein -
  IB938_RS06425 (IB938_06425) - 1257703..1258041 (-) 339 WP_011054681.1 hypothetical protein -
  IB938_RS06430 (IB938_06430) - 1258001..1258423 (-) 423 WP_011054682.1 phage Gp19/Gp15/Gp42 family protein -
  IB938_RS06435 (IB938_06435) - 1258433..1258633 (-) 201 WP_010922460.1 hypothetical protein -
  IB938_RS06440 (IB938_06440) - 1258633..1259544 (-) 912 WP_011528788.1 phage major capsid protein -
  IB938_RS06445 (IB938_06445) - 1259569..1260030 (-) 462 WP_010922462.1 capsid assembly scaffolding protein Gp46 family protein -
  IB938_RS06450 (IB938_06450) - 1260110..1261525 (-) 1416 WP_021299324.1 phage terminase large subunit-like protein -
  IB938_RS06455 (IB938_06455) - 1261607..1261843 (-) 237 Protein_1236 hypothetical protein -
  IB938_RS06460 (IB938_06460) - 1261845..1262111 (-) 267 WP_011054745.1 hypothetical protein -
  IB938_RS06465 (IB938_06465) - 1262163..1262387 (-) 225 WP_002994100.1 hypothetical protein -
  IB938_RS06470 (IB938_06470) - 1262393..1263886 (-) 1494 WP_010922467.1 hypothetical protein -
  IB938_RS06475 (IB938_06475) - 1263879..1265147 (-) 1269 WP_010922468.1 phage portal protein -
  IB938_RS06480 (IB938_06480) - 1265144..1265500 (-) 357 WP_002994106.1 hypothetical protein -
  IB938_RS06485 (IB938_06485) - 1265648..1265992 (-) 345 WP_011054690.1 HNH endonuclease signature motif containing protein -
  IB938_RS06490 (IB938_06490) - 1266100..1266519 (-) 420 WP_011528791.1 DUF1492 domain-containing protein -
  IB938_RS06495 (IB938_06495) - 1266595..1266846 (-) 252 WP_011054692.1 hypothetical protein -
  IB938_RS06500 (IB938_06500) - 1266843..1266998 (-) 156 WP_011054693.1 hypothetical protein -
  IB938_RS06505 (IB938_06505) - 1266995..1267312 (-) 318 WP_011054694.1 DUF1372 family protein -
  IB938_RS06510 (IB938_06510) - 1267348..1267860 (-) 513 WP_011054695.1 hypothetical protein -
  IB938_RS06515 (IB938_06515) - 1267857..1268189 (-) 333 WP_011184741.1 hypothetical protein -
  IB938_RS06520 (IB938_06520) - 1268200..1269546 (-) 1347 WP_011054697.1 PcfJ domain-containing protein -
  IB938_RS06525 (IB938_06525) - 1269543..1269938 (-) 396 WP_011054698.1 Cas9 inhibitor AcrIIA9 family protein -
  IB938_RS06530 (IB938_06530) - 1270303..1271100 (-) 798 WP_011054699.1 PD-(D/E)XK nuclease-like domain-containing protein -
  IB938_RS06535 (IB938_06535) - 1271093..1271293 (-) 201 WP_000594115.1 hypothetical protein -
  IB938_RS06540 (IB938_06540) - 1271290..1272216 (-) 927 WP_011054700.1 recombinase RecT -
  IB938_RS06545 (IB938_06545) - 1272219..1272548 (-) 330 WP_011528796.1 hypothetical protein -
  IB938_RS06550 (IB938_06550) - 1272604..1272810 (-) 207 WP_011017565.1 hypothetical protein -
  IB938_RS06555 (IB938_06555) - 1272819..1272959 (-) 141 WP_011017992.1 hypothetical protein -
  IB938_RS06560 (IB938_06560) - 1272956..1273189 (-) 234 WP_002985387.1 hypothetical protein -
  IB938_RS06565 (IB938_06565) - 1273170..1273556 (-) 387 WP_002985388.1 DnaD domain-containing protein -
  IB938_RS09695 - 1273715..1273954 (-) 240 WP_002985390.1 hypothetical protein -
  IB938_RS06570 (IB938_06570) - 1274054..1274239 (-) 186 WP_061046295.1 hypothetical protein -
  IB938_RS06575 (IB938_06575) - 1274241..1274552 (-) 312 WP_010922478.1 excisionase -
  IB938_RS06580 (IB938_06580) - 1274822..1275034 (-) 213 WP_010922479.1 helix-turn-helix domain-containing protein -
  IB938_RS06585 (IB938_06585) - 1275236..1275991 (+) 756 WP_010922480.1 helix-turn-helix domain-containing protein -
  IB938_RS06590 (IB938_06590) - 1276003..1276521 (+) 519 WP_011528799.1 HIRAN domain-containing protein -
  IB938_RS06595 (IB938_06595) - 1276645..1277787 (+) 1143 WP_003051793.1 tyrosine-type recombinase/integrase -
  IB938_RS06600 (IB938_06600) - 1277876..1278151 (-) 276 WP_002983920.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 6840.81 Da        Isoelectric Point: 4.7023

>NTDB_id=480825 IB938_RS06335 WP_011528776.1 1242472..1242654(-) (prx) [Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease]
MLTYNEFKQAIDNGYIAGDTVAIVRKDGQIFDYVLPHEKVKNGEVVTKEKVEEVLVELSR

Nucleotide


Download         Length: 183 bp        

>NTDB_id=480825 IB938_RS06335 WP_011528776.1 1242472..1242654(-) (prx) [Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease]
ATGCTAACATACAACGAGTTTAAGCAAGCGATTGACAATGGATATATCGCAGGCGATACAGTAGCGATCGTGCGTAAAGA
CGGACAGATTTTTGATTATGTGTTGCCACATGAGAAAGTAAAGAATGGAGAAGTTGTGACTAAGGAAAAAGTGGAAGAGG
TGCTGGTGGAGCTTTCGAGATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A5W9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS8232

98.333

100

0.983
  prx Streptococcus pyogenes MGAS315

83.333

100

0.833
  prx Streptococcus pyogenes MGAS315

78.333

100

0.783
  prx Streptococcus pyogenes MGAS315

71.667

100

0.717
  prx Streptococcus pyogenes MGAS315

87.805

68.333

0.6
  prx Streptococcus pyogenes MGAS315

81.395

71.667

0.583
  prx Streptococcus pyogenes MGAS315

76.19

70

0.533