NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	JTR57_RS02045	Genome accession	NZ_CP070962
Coordinates	404575..405234 (-)	Length	219 a.a.
NCBI ID	WP_001221495.1	Uniprot ID	P52076
Organism	Escherichia coli strain K-12 J53
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 399575..410234

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JTR57_RS02020	parE	399666..401558 (+)	1893	WP_000195296.1	DNA topoisomerase IV subunit B	-
JTR57_RS02025	ygiN	401606..401920 (-)	315	WP_000958598.1	putative quinol monooxygenase	-
JTR57_RS02030	mdaB	401951..402532 (-)	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
JTR57_RS02035	ygiZ	402851..403183 (+)	333	WP_000917684.1	DUF2645 family protein	-
JTR57_RS02040	qseC	403229..404578 (-)	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
JTR57_RS02045	ciaR	404575..405234 (-)	660	WP_001221495.1	quorum sensing response regulator transcription factor QseB	Regulator
JTR57_RS02050	ygiW	405386..405778 (+)	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
JTR57_RS02055	ygiV	405831..406313 (+)	483	WP_000183505.1	GyrI-like domain-containing protein	-
JTR57_RS02060	mqsR	406518..406814 (+)	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	-
JTR57_RS02065	mqsA	406816..407211 (+)	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	-
JTR57_RS02070	ygiS	407344..408951 (+)	1608	WP_001295629.1	ABC transporter substrate-binding protein	-

Sequence

Protein

Download Length: 219 a.a. Molecular weight: 24677.59 Da Isoelectric Point: 6.9850

                                >NTDB_id=475178 JTR57_RS02045 WP_001221495.1 404575..405234(-) (ciaR) [Escherichia coli strain K-12 J53]

MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA

RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL

LMRNAGRVLSRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide

Download Length: 660 bp

                                >NTDB_id=475178 JTR57_RS02045 WP_001221495.1 404575..405234(-) (ciaR) [Escherichia coli strain K-12 J53]

ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT

CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT

TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG

CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA

AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC

TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA

CTGATGCGTAACGCTGGTCGGGTACTGTCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG

TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT

ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	P52076

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	37.885	100	0.393
ciaR	Streptococcus pneumoniae D39	37.885	100	0.393
ciaR	Streptococcus pneumoniae R6	37.885	100	0.393
ciaR	Streptococcus pneumoniae TIGR4	37.885	100	0.393
ciaR	Streptococcus mutans UA159	35.426	100	0.361

Detailed information NTG0475178