NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	H1R75_RS05380	Genome accession	NZ_CP059471
Coordinates	1038355..1039029 (-)	Length	224 a.a.
NCBI ID	WP_024344055.1	Uniprot ID	A0A239RAE4
Organism	Streptococcus equinus strain MDC1
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1033355..1044029

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1R75_RS05355 (H1R75_05355)	deoC	1033838..1034503 (-)	666	WP_074483529.1	deoxyribose-phosphate aldolase	-
H1R75_RS05360 (H1R75_05360)	-	1035006..1035596 (-)	591	WP_024344058.1	class I SAM-dependent methyltransferase	-
H1R75_RS05365 (H1R75_05365)	coaA	1035710..1036630 (+)	921	WP_033152659.1	type I pantothenate kinase	-
H1R75_RS05370 (H1R75_05370)	rpsT	1036706..1036957 (+)	252	WP_004231769.1	30S ribosomal protein S20	-
H1R75_RS05375 (H1R75_05375)	ciaH	1037040..1038365 (-)	1326	WP_024344056.1	sensor histidine kinase	Regulator
H1R75_RS05380 (H1R75_05380)	ciaR	1038355..1039029 (-)	675	WP_024344055.1	response regulator transcription factor	Regulator
H1R75_RS05385 (H1R75_05385)	-	1039183..1041726 (-)	2544	WP_182001140.1	M1 family metallopeptidase	-
H1R75_RS05390 (H1R75_05390)	phoU	1041935..1042588 (-)	654	WP_024344053.1	phosphate signaling complex protein PhoU	-
H1R75_RS05395 (H1R75_05395)	pstB	1042620..1043378 (-)	759	WP_024344052.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25372.99 Da Isoelectric Point: 4.3773

                                >NTDB_id=469828 H1R75_RS05380 WP_024344055.1 1038355..1039029(-) (ciaR) [Streptococcus equinus strain MDC1]

MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGISTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNNNTLSYHELTADTSTNTTTVNGEKVELLGKEFDLLVY

FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTSFANNLQTLRSVGYILKDAE

Nucleotide

Download Length: 675 bp

                                >NTDB_id=469828 H1R75_RS05380 WP_024344055.1 1038355..1039029(-) (ciaR) [Streptococcus equinus strain MDC1]

ATGATTAAAATTTTATTAGTAGAAGACGATTTGAGCTTGTCAAATTCAATTTTTGATTTTTTGGATGATTTTGCTGATGT

CATGCAAGTTTTTGATGGCGCAGAAGGCTTATATGAAGCAGAAAGTGGTGTTTATGACCTTATTTTGCTTGATTTGATGT

TGCCAGAAAAAGATGGTTTTCAAGTTCTTAAAGAATTACGTGAAAAAGGCATTTCAACACCTGTTTTGATTATGACAGCT

AAAGAAAGTCTTGATGACAAAGGACATGGATTCGAATTAGGTGCTGATGATTACCTAACAAAACCATTTTATCTTGAAGA

ACTTAAGATGCGTATTCAAGCTCTTTTAAAACGTTCAGGTAAATTTAATAACAATACTTTGTCATATCATGAATTAACTG

CGGATACTTCAACAAATACAACAACTGTTAATGGTGAAAAAGTTGAATTACTAGGTAAAGAGTTTGATTTGTTAGTGTAC

TTTTTGCAAAACCAAAATGTCATTTTGCCAAAATCACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACAACAAT

TTCAGTTGTTGAAGTATATGTTTCAAAAATTCGTAAAAAACTCAAAGGTACTAGCTTTGCCAATAATCTTCAAACACTAC

GTAGTGTAGGTTACATATTGAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A239RAE4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	91.928	99.554	0.915
ciaR	Streptococcus pneumoniae Rx1	87.5	100	0.875
ciaR	Streptococcus pneumoniae D39	87.5	100	0.875
ciaR	Streptococcus pneumoniae R6	87.5	100	0.875
ciaR	Streptococcus pneumoniae TIGR4	87.5	100	0.875
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.767	100	0.393
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362
vicR	Streptococcus mutans UA159	34.764	100	0.362

Detailed information NTG0469828