NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	HW271_RS03400	Genome accession	NZ_CP058258
Coordinates	696216..696887 (+)	Length	223 a.a.
NCBI ID	WP_016465655.1	Uniprot ID	-
Organism	Streptococcus sp. oral taxon 061 strain F0704
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 691216..701887

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HW271_RS03380 (HW271_03380)	-	691668..692168 (+)	501	WP_178894842.1	NUDIX hydrolase	-
HW271_RS03385 (HW271_03385)	-	692146..692994 (+)	849	WP_178894843.1	putative PEP-binding protein	-
HW271_RS03390 (HW271_03390)	-	692991..693431 (+)	441	WP_178894844.1	ASCH domain-containing protein	-
HW271_RS03395 (HW271_03395)	-	693554..696100 (+)	2547	WP_178894845.1	M1 family metallopeptidase	-
HW271_RS03400 (HW271_03400)	ciaR	696216..696887 (+)	672	WP_016465655.1	two-component system response regulator CiaR	Regulator
HW271_RS03405 (HW271_03405)	ciaH	696880..698214 (+)	1335	WP_178894846.1	cell wall metabolism sensor histidine kinase WalK	Regulator
HW271_RS03410 (HW271_03410)	-	698241..698516 (-)	276	WP_178894847.1	DUF3270 family protein	-
HW271_RS03415 (HW271_03415)	-	698887..699942 (+)	1056	WP_178894848.1	ABC transporter permease	-
HW271_RS03420 (HW271_03420)	-	699956..700636 (+)	681	WP_006154146.1	ABC transporter ATP-binding protein	-
HW271_RS03425 (HW271_03425)	-	700747..701676 (+)	930	WP_178894849.1	peptidase U32 family protein	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 25345.12 Da Isoelectric Point: 4.4452

                                >NTDB_id=463213 HW271_RS03400 WP_016465655.1 696216..696887(+) (ciaR) [Streptococcus sp. oral taxon 061 strain F0704]

MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGISTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDLTVNLSTNEVKVHDTSVELLGKEFELLVY

FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKHV

Nucleotide

Download Length: 672 bp

                                >NTDB_id=463213 HW271_RS03400 WP_016465655.1 696216..696887(+) (ciaR) [Streptococcus sp. oral taxon 061 strain F0704]

ATGATCAAAATTCTATTAGTGGAAGATGACCTAGGCCTGTCAAATTCAGTCTTTGATTTTTTGGATGATTTTGCTGATGT

CATGCAAGTTTTTGATGGAGAAGAAGGTCTTTATGAGGCTGAAAGTGGCGTATATGATTTGATTCTATTGGACTTGATGT

TGCCTGAAAAAAATGGATTCCAAGTTTTAAAAGAATTGCGTGAAAAAGGTATTTCGACTCCTGTTCTGATCATGACAGCC

AAGGAAAGTCTCGATGACAAAGGACATGGATTTGAACTTGGGGCAGACGATTATCTAACAAAACCCTTCTATTTGGAAGA

GCTCAAAATGCGTATCCAAGCGCTTCTTAAACGTTCTGGCAAATTTAACGAAAATACTCTTTCTTATGGAGACTTGACGG

TTAACCTCTCTACAAATGAGGTTAAGGTTCACGATACTTCTGTTGAGTTACTTGGTAAAGAATTTGAACTCTTGGTCTAT

TTCCTCCAAAACCAAAATGTTATCTTACCTAAGACACAGATTTTTGACCGTTTATGGGGATTTGATAGTGATACAACTAT

TTCCGTTGTAGAAGTTTATGTATCAAAAGTTCGTAAGAAATTAAAGGGAACAGCCTTTGCTGAAAATCTCCAAACCTTAC

GCAGTGTTGGGTATATTTTAAAACATGTTTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	94.619	100	0.946
ciaR	Streptococcus pneumoniae D39	94.619	100	0.946
ciaR	Streptococcus pneumoniae R6	94.619	100	0.946
ciaR	Streptococcus pneumoniae TIGR4	94.619	100	0.946
ciaR	Streptococcus mutans UA159	88.235	99.103	0.874
vicR	Streptococcus mutans UA159	36.91	100	0.386
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.889	100	0.372
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.363

Detailed information NTG0463213