Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   HW271_RS03405 Genome accession   NZ_CP058258
Coordinates   696880..698214 (+) Length   444 a.a.
NCBI ID   WP_178894846.1    Uniprot ID   A0A7H8Z9A3
Organism   Streptococcus sp. oral taxon 061 strain F0704     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 691880..703214
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HW271_RS03385 (HW271_03385) - 692146..692994 (+) 849 WP_178894843.1 putative PEP-binding protein -
  HW271_RS03390 (HW271_03390) - 692991..693431 (+) 441 WP_178894844.1 ASCH domain-containing protein -
  HW271_RS03395 (HW271_03395) - 693554..696100 (+) 2547 WP_178894845.1 M1 family metallopeptidase -
  HW271_RS03400 (HW271_03400) ciaR 696216..696887 (+) 672 WP_016465655.1 two-component system response regulator CiaR Regulator
  HW271_RS03405 (HW271_03405) ciaH 696880..698214 (+) 1335 WP_178894846.1 cell wall metabolism sensor histidine kinase WalK Regulator
  HW271_RS03410 (HW271_03410) - 698241..698516 (-) 276 WP_178894847.1 DUF3270 family protein -
  HW271_RS03415 (HW271_03415) - 698887..699942 (+) 1056 WP_178894848.1 ABC transporter permease -
  HW271_RS03420 (HW271_03420) - 699956..700636 (+) 681 WP_006154146.1 ABC transporter ATP-binding protein -
  HW271_RS03425 (HW271_03425) - 700747..701676 (+) 930 WP_178894849.1 peptidase U32 family protein -
  HW271_RS03430 (HW271_03430) rpiA 701780..702463 (+) 684 WP_178894850.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50596.01 Da        Isoelectric Point: 8.2555

>NTDB_id=463214 HW271_RS03405 WP_178894846.1 696880..698214(+) (ciaH) [Streptococcus sp. oral taxon 061 strain F0704]
MFNKFKKNWYAEDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLLALSNNPQDIIQLAVNRATEDVKDIDGGN
VTSNPDKRVTISSNTEVILLDSNLNQLVTGNRFLGLDRITFNKKDLNHIRQLHIVNSYGQDEVYRVVLTEMKIDSVSSNI
KYAAVLINTSQLEQISQNHEQLIVVVMASFWILSILASLYLARVSVKPLLESMQKQQSFVENASHELRTPLAVLQNRLET
LFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELGEVEPDFFNTIFTNYEMIASENDRVFRFENRVH
RTIITDKLLLKQLMTILFDNAVKYTEEEGDIYFEISTTERSLYLTVADNGIGISAADKKKIFDRFYRVDKARTRQKGGFG
LGLSLAKQIVDALKGSISVKDNKPNGTVFEVKIAISTPSKRKNK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=463214 HW271_RS03405 WP_178894846.1 696880..698214(+) (ciaH) [Streptococcus sp. oral taxon 061 strain F0704]
ATGTTTAATAAATTTAAAAAGAATTGGTACGCAGAAGATTTCAGCTACTTTATCCGTAACTTTGGAGTATTTACTCTGAT
TTTCTCTGCTATGACCTTGATTATCTTGCAGGTTATGCACTCCAGCCTCTATACATCTGTAGATGAGAAACTTTTAGCGC
TTAGCAATAATCCTCAGGATATCATTCAATTAGCGGTCAATCGTGCAACAGAAGATGTTAAGGATATAGATGGTGGAAAT
GTTACCTCAAATCCGGATAAAAGAGTCACAATTAGCTCCAATACGGAAGTTATTTTGCTGGATTCTAACCTCAATCAGTT
AGTAACTGGCAATCGCTTCTTAGGTTTGGATAGAATAACCTTCAATAAAAAGGATTTAAACCATATTCGTCAGCTTCATA
TTGTCAATAGCTATGGTCAGGATGAGGTTTATCGTGTCGTCTTGACAGAAATGAAAATTGATTCTGTCTCAAGTAACATT
AAGTATGCTGCTGTCCTAATCAATACCAGCCAGCTAGAACAAATCAGTCAAAATCACGAACAGTTAATCGTAGTGGTGAT
GGCAAGTTTTTGGATTCTATCTATCTTGGCTAGTCTCTACCTTGCTCGTGTCAGTGTTAAGCCCCTACTCGAAAGTATGC
AAAAGCAGCAGAGCTTTGTGGAGAATGCTAGTCATGAATTACGGACTCCTTTAGCTGTTCTCCAAAATCGTTTGGAAACA
CTTTTTAGAAAACCAGAAGCGACTATTATGGAGTCTAGTGAGAGCATTGCTTCGAGTTTGGAAGAAGTTCGAAACATGAG
ATTCCTAACGACGAATTTGCTCAATTTAGCGCGTAGAGATGACGGGATTAAGCCGGAGCTTGGAGAAGTAGAGCCCGACT
TCTTTAATACGATCTTTACCAACTATGAAATGATTGCATCTGAGAATGATCGTGTCTTTCGTTTCGAAAACCGTGTGCAT
CGAACCATTATTACAGATAAACTTCTCCTCAAGCAGTTGATGACCATTCTGTTTGACAATGCTGTCAAGTATACGGAAGA
AGAAGGAGATATTTATTTTGAGATTTCAACGACAGAACGCAGTCTATATTTAACAGTAGCAGATAATGGAATCGGTATCT
CTGCAGCAGATAAAAAGAAAATCTTTGACCGATTTTATCGTGTTGATAAGGCACGTACACGTCAAAAGGGAGGTTTTGGT
CTTGGTTTGTCATTAGCCAAGCAAATCGTTGATGCCCTTAAGGGAAGCATCAGTGTGAAAGATAACAAACCTAATGGAAC
AGTTTTTGAAGTCAAAATAGCTATCTCAACGCCATCAAAACGAAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(326-433)

His Kinase A (phospho-acceptor) domain (HisKA)

(216-282)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H8Z9A3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

79.684

99.775

0.795
  ciaH Streptococcus pneumoniae D39

79.684

99.775

0.795
  ciaH Streptococcus pneumoniae R6

79.684

99.775

0.795
  ciaH Streptococcus pneumoniae TIGR4

79.684

99.775

0.795
  ciaH Streptococcus mutans UA159

55.427

97.523

0.541