Detailed information
Bioinformatically predicted
Overview
| Name | clpP | Type | Regulator |
| Locus tag | HVV27_RS01710 | Genome accession | NZ_CP055246 |
| Coordinates | 328649..329239 (+) | Length | 196 a.a. |
| NCBI ID | WP_002985850.1 | Uniprot ID | A0A9X8T4H8 |
| Organism | Streptococcus pyogenes strain TSPY767 | ||
| Function | degradation of ComX (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 304387..386047 | 328649..329239 | within | 0 |
Gene organization within MGE regions
Location: 304387..386047
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HVV27_RS01575 (HVV27_01570) | - | 304400..304642 (+) | 243 | WP_002985908.1 | YneF family protein | - |
| HVV27_RS01580 (HVV27_01575) | racE | 304820..305614 (+) | 795 | WP_002985906.1 | glutamate racemase | - |
| HVV27_RS01585 (HVV27_01580) | - | 305611..306597 (+) | 987 | WP_011284524.1 | nucleoside-triphosphate diphosphatase | - |
| HVV27_RS01590 (HVV27_01585) | - | 306576..307097 (+) | 522 | WP_002985902.1 | metallophosphoesterase | - |
| HVV27_RS01595 (HVV27_01590) | cbpB | 307094..307555 (+) | 462 | WP_011528278.1 | cyclic-di-AMP-binding protein CbpB | - |
| HVV27_RS01600 (HVV27_01595) | xerD | 307552..308298 (+) | 747 | WP_002995825.1 | site-specific tyrosine recombinase XerD | - |
| HVV27_RS01605 (HVV27_01600) | - | 308298..309002 (+) | 705 | WP_002985896.1 | segregation/condensation protein A | - |
| HVV27_RS01610 (HVV27_01605) | scpB | 308999..309550 (+) | 552 | WP_002985894.1 | SMC-Scp complex subunit ScpB | - |
| HVV27_RS01615 (HVV27_01610) | - | 309671..310393 (+) | 723 | WP_002990967.1 | pseudouridine synthase | - |
| HVV27_RS01620 (HVV27_01615) | yidD | 310390..310653 (+) | 264 | WP_002985889.1 | membrane protein insertion efficiency factor YidD | - |
| HVV27_RS01625 (HVV27_01620) | - | 310831..311379 (+) | 549 | WP_002990965.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
| HVV27_RS01630 (HVV27_01625) | - | 311690..312253 (+) | 564 | WP_002990963.1 | ECF transporter S component | - |
| HVV27_RS01635 (HVV27_01630) | - | 312255..312908 (+) | 654 | WP_011017413.1 | phosphatase PAP2 family protein | - |
| HVV27_RS01640 (HVV27_01635) | - | 313201..314121 (+) | 921 | WP_011017414.1 | TIGR01212 family radical SAM protein | - |
| HVV27_RS01645 (HVV27_01640) | - | 314160..314714 (+) | 555 | WP_002990955.1 | class I SAM-dependent methyltransferase | - |
| HVV27_RS01650 (HVV27_01645) | - | 314847..316181 (+) | 1335 | WP_002990953.1 | hemolysin family protein | - |
| HVV27_RS01655 (HVV27_01650) | pflA | 316259..317050 (+) | 792 | WP_042769810.1 | pyruvate formate-lyase-activating protein | - |
| HVV27_RS01660 (HVV27_01655) | - | 317181..318116 (+) | 936 | WP_002990948.1 | manganese-dependent inorganic pyrophosphatase | - |
| HVV27_RS01665 (HVV27_01660) | - | 318192..318845 (+) | 654 | WP_011528282.1 | DUF1803 domain-containing protein | - |
| HVV27_RS01670 (HVV27_01665) | - | 318890..319891 (-) | 1002 | WP_042769807.1 | iron ABC transporter permease | - |
| HVV27_RS01675 (HVV27_01670) | - | 319888..320940 (-) | 1053 | WP_011054214.1 | iron ABC transporter permease | - |
| HVV27_RS01680 (HVV27_01675) | - | 320930..321862 (-) | 933 | WP_011528284.1 | iron-hydroxamate ABC transporter substrate-binding protein | - |
| HVV27_RS01685 (HVV27_01680) | - | 321888..322670 (-) | 783 | WP_011528285.1 | ABC transporter ATP-binding protein | - |
| HVV27_RS01690 (HVV27_01685) | - | 322806..324259 (-) | 1454 | Protein_295 | IS1182 family transposase | - |
| HVV27_RS01695 (HVV27_01690) | - | 324461..325906 (-) | 1446 | WP_021299191.1 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase | - |
| HVV27_RS01700 (HVV27_01695) | - | 325994..327628 (+) | 1635 | WP_011528289.1 | polysaccharide biosynthesis protein | - |
| HVV27_RS01705 (HVV27_01700) | upp | 327796..328425 (+) | 630 | WP_002985854.1 | uracil phosphoribosyltransferase | - |
| HVV27_RS01710 (HVV27_01705) | clpP | 328649..329239 (+) | 591 | WP_002985850.1 | ATP-dependent Clp protease proteolytic subunit | Regulator |
| HVV27_RS01715 (HVV27_01710) | - | 329734..330027 (+) | 294 | WP_002990928.1 | YlbG family protein | - |
| HVV27_RS01720 (HVV27_01715) | tmk | 330258..330893 (+) | 636 | WP_021299190.1 | dTMP kinase | - |
| HVV27_RS01725 (HVV27_01720) | - | 330911..331786 (+) | 876 | WP_011528291.1 | DNA polymerase III subunit delta' | - |
| HVV27_RS01730 (HVV27_01725) | - | 331805..332044 (+) | 240 | WP_021299187.1 | PSP1 C-terminal domain-containing protein | - |
| HVV27_RS01735 (HVV27_01730) | yabA | 332448..332771 (+) | 324 | WP_002985838.1 | DNA replication initiation control protein YabA | - |
| HVV27_RS01740 (HVV27_01735) | rsmI | 332776..333639 (+) | 864 | WP_002990904.1 | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | - |
| HVV27_RS01745 (HVV27_01740) | - | 333666..334058 (+) | 393 | WP_002985833.1 | DUF5684 domain-containing protein | - |
| HVV27_RS01750 (HVV27_01745) | - | 334105..334734 (-) | 630 | WP_011528296.1 | copper homeostasis protein CutC | - |
| HVV27_RS01755 (HVV27_01750) | - | 335033..335389 (+) | 357 | WP_002995120.1 | arsenate reductase family protein | - |
| HVV27_RS01760 (HVV27_01755) | - | 335463..336290 (-) | 828 | WP_021299194.1 | exodeoxyribonuclease III | - |
| HVV27_RS01765 (HVV27_01760) | lctO | 336524..337705 (+) | 1182 | WP_044555073.1 | L-lactate oxidase | - |
| HVV27_RS01770 (HVV27_01765) | scpC | 337971..342914 (+) | 4944 | WP_060388498.1 | CXC chemokine-degrading serine protease SpyCEP | - |
| HVV27_RS01775 (HVV27_01770) | - | 343686..344393 (+) | 708 | WP_011528304.1 | YoaK family protein | - |
| HVV27_RS01780 (HVV27_01775) | - | 344545..345609 (+) | 1065 | Protein_313 | ISAs1 family transposase | - |
| HVV27_RS01785 (HVV27_01780) | metG | 345889..347889 (+) | 2001 | WP_011528307.1 | methionine--tRNA ligase | - |
| HVV27_RS01790 (HVV27_01785) | nrdF | 348384..349397 (+) | 1014 | WP_011528309.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| HVV27_RS01795 (HVV27_01790) | nrdI | 349401..349835 (+) | 435 | WP_011528310.1 | class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI | - |
| HVV27_RS01800 (HVV27_01795) | nrdE | 349855..352035 (+) | 2181 | WP_011528311.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| HVV27_RS01805 (HVV27_01800) | - | 352241..352993 (-) | 753 | WP_021299376.1 | ADP-ribosyltransferase | - |
| HVV27_RS01810 (HVV27_01805) | - | 353452..353946 (+) | 495 | WP_044555125.1 | hypothetical protein | - |
| HVV27_RS01815 (HVV27_01810) | - | 354184..354444 (+) | 261 | WP_060388499.1 | hypothetical protein | - |
| HVV27_RS01820 (HVV27_01815) | - | 354853..355104 (+) | 252 | WP_011017435.1 | hypothetical protein | - |
| HVV27_RS01825 (HVV27_01820) | - | 355198..355905 (-) | 708 | WP_011528316.1 | hypothetical protein | - |
| HVV27_RS01830 (HVV27_01825) | - | 356418..357385 (-) | 968 | Protein_323 | DUF3644 domain-containing protein | - |
| HVV27_RS01835 (HVV27_01830) | - | 358085..358321 (+) | 237 | WP_002990844.1 | DUF2829 domain-containing protein | - |
| HVV27_RS01840 (HVV27_01835) | - | 358314..359012 (+) | 699 | WP_011528320.1 | 3-oxoacyl-ACP reductase | - |
| HVV27_RS01845 (HVV27_01840) | - | 359088..360047 (+) | 960 | WP_044555074.1 | Gfo/Idh/MocA family protein | - |
| HVV27_RS01850 (HVV27_01845) | - | 360380..361717 (+) | 1338 | WP_002985796.1 | MFS transporter | - |
| HVV27_RS01855 (HVV27_01850) | glmU | 361840..363222 (+) | 1383 | WP_021299380.1 | bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU | - |
| HVV27_RS01860 (HVV27_01855) | - | 363253..363807 (+) | 555 | WP_002990829.1 | NUDIX hydrolase | - |
| HVV27_RS01865 (HVV27_01860) | macP | 363807..364058 (+) | 252 | WP_002990826.1 | cell wall synthase accessory phosphoprotein MacP | - |
| HVV27_RS01870 (HVV27_01865) | - | 364078..364773 (+) | 696 | WP_011528323.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
| HVV27_RS01875 (HVV27_01870) | - | 364924..365265 (+) | 342 | WP_011528324.1 | hypothetical protein | - |
| HVV27_RS01880 (HVV27_01875) | - | 365362..366009 (-) | 648 | WP_002985785.1 | metal-dependent transcriptional regulator | - |
| HVV27_RS01885 (HVV27_01880) | - | 366155..367087 (+) | 933 | WP_004218965.1 | metal ABC transporter substrate-binding protein | - |
| HVV27_RS01890 (HVV27_01885) | - | 367151..367876 (+) | 726 | WP_021299377.1 | metal ABC transporter ATP-binding protein | - |
| HVV27_RS01895 (HVV27_01890) | - | 367877..368731 (+) | 855 | WP_011017448.1 | metal ABC transporter permease | - |
| HVV27_RS01900 (HVV27_01895) | - | 368879..369685 (-) | 807 | WP_002990808.1 | peptidylprolyl isomerase | - |
| HVV27_RS01905 (HVV27_01900) | - | 369902..372307 (+) | 2406 | WP_011528327.1 | DNA translocase FtsK | - |
| HVV27_RS01910 (HVV27_01905) | - | 372377..372730 (-) | 354 | WP_011528328.1 | DUF3397 domain-containing protein | - |
| HVV27_RS01915 (HVV27_01910) | rplK | 372974..373399 (+) | 426 | WP_002990800.1 | 50S ribosomal protein L11 | - |
| HVV27_RS01920 (HVV27_01915) | rplA | 373505..374194 (+) | 690 | WP_002985768.1 | 50S ribosomal protein L1 | - |
| HVV27_RS01925 (HVV27_01920) | pyrH | 374516..375244 (+) | 729 | WP_002985765.1 | UMP kinase | - |
| HVV27_RS01930 (HVV27_01925) | frr | 375273..375830 (+) | 558 | WP_002985763.1 | ribosome recycling factor | - |
| HVV27_RS01935 (HVV27_01930) | - | 375939..376796 (+) | 858 | WP_011528329.1 | S1 RNA-binding domain-containing protein | - |
| HVV27_RS01940 (HVV27_01935) | msrA | 376869..377378 (+) | 510 | WP_002985759.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| HVV27_RS01945 (HVV27_01940) | - | 377375..377590 (+) | 216 | WP_002985757.1 | YozE family protein | - |
| HVV27_RS01950 (HVV27_01945) | - | 377746..378927 (+) | 1182 | WP_219966498.1 | LysM peptidoglycan-binding domain-containing protein | - |
| HVV27_RS01955 (HVV27_01950) | - | 379243..381015 (+) | 1773 | WP_042769843.1 | oleate hydratase | - |
| HVV27_RS01960 (HVV27_01955) | - | 381174..382225 (+) | 1052 | Protein_349 | PhoH family protein | - |
| HVV27_RS01965 (HVV27_01960) | - | 382271..382846 (+) | 576 | WP_009880369.1 | uracil-DNA glycosylase family protein | - |
| HVV27_RS01970 (HVV27_01965) | ybeY | 383005..383502 (+) | 498 | WP_002985748.1 | rRNA maturation RNase YbeY | - |
| HVV27_RS01975 (HVV27_01970) | - | 383483..383890 (+) | 408 | WP_002985746.1 | diacylglycerol kinase family protein | - |
| HVV27_RS01980 (HVV27_01975) | era | 384010..384906 (+) | 897 | WP_003047080.1 | GTPase Era | - |
| HVV27_RS01985 (HVV27_01980) | - | 384926..385402 (+) | 477 | WP_014635332.1 | NUDIX hydrolase | - |
| HVV27_RS09250 | - | 385707..385961 (-) | 255 | WP_010921971.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 196 a.a. Molecular weight: 21648.88 Da Isoelectric Point: 5.2834
>NTDB_id=457148 HVV27_RS01710 WP_002985850.1 328649..329239(+) (clpP) [Streptococcus pyogenes strain TSPY767]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK
Nucleotide
Download Length: 591 bp
>NTDB_id=457148 HVV27_RS01710 WP_002985850.1 328649..329239(+) (clpP) [Streptococcus pyogenes strain TSPY767]
ATGATTCCTGTTGTTATTGAACAAACTAGCCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACTAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCCGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCGCAAAATGCTGGAAAA
ACGATTAAACAAATCCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA
ATGATTCCTGTTGTTATTGAACAAACTAGCCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACTAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCCGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCGCAAAATGCTGGAAAA
ACGATTAAACAAATCCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| clpP | Streptococcus pyogenes MGAS315 |
100 |
100 |
1 |
| clpP | Streptococcus pyogenes JRS4 |
100 |
100 |
1 |
| clpP | Streptococcus mutans UA159 |
90.816 |
100 |
0.908 |
| clpP | Streptococcus pneumoniae Rx1 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus pneumoniae D39 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus pneumoniae R6 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus pneumoniae TIGR4 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus thermophilus LMG 18311 |
89.796 |
100 |
0.898 |
| clpP | Streptococcus thermophilus LMD-9 |
89.796 |
100 |
0.898 |
| clpP | Lactococcus lactis subsp. lactis strain DGCC12653 |
86.224 |
100 |
0.862 |
| clpP | Lactococcus lactis subsp. cremoris KW2 |
85.714 |
100 |
0.857 |
| clpP | Bacillus subtilis subsp. subtilis str. 168 |
57.143 |
100 |
0.571 |
| clpP | Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 |
56.995 |
98.469 |
0.561 |