NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	HRE60_RS05530	Genome accession	NZ_CP054153
Coordinates	1150747..1151421 (-)	Length	224 a.a.
NCBI ID	WP_002891134.1	Uniprot ID	J7TS49
Organism	Streptococcus salivarius strain DB-B5
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1145747..1156421

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HRE60_RS05505 (HRE60_05505)	-	1146052..1147329 (-)	1278	WP_181670386.1	pyrimidine-nucleoside phosphorylase	-
HRE60_RS05510 (HRE60_05510)	-	1147326..1147916 (-)	591	WP_045768632.1	class I SAM-dependent methyltransferase	-
HRE60_RS05515 (HRE60_05515)	coaA	1148029..1148949 (+)	921	WP_181670387.1	type I pantothenate kinase	-
HRE60_RS05520 (HRE60_05520)	rpsT	1149019..1149255 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
HRE60_RS05525 (HRE60_05525)	ciaH	1149342..1150757 (-)	1416	WP_181670388.1	HAMP domain-containing sensor histidine kinase	Regulator
HRE60_RS05530 (HRE60_05530)	ciaR	1150747..1151421 (-)	675	WP_002891134.1	response regulator transcription factor	Regulator
HRE60_RS05535 (HRE60_05535)	-	1151620..1153290 (-)	1671	WP_004182072.1	formate--tetrahydrofolate ligase	-
HRE60_RS05540 (HRE60_05540)	-	1153484..1154167 (+)	684	WP_181670389.1	phosphopantothenate--cysteine ligase	-
HRE60_RS05545 (HRE60_05545)	coaC	1154160..1154705 (+)	546	WP_004182014.1	phosphopantothenoylcysteine decarboxylase	-
HRE60_RS05550 (HRE60_05550)	-	1154734..1155306 (+)	573	WP_181670390.1	ECF transporter S component	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25362.02 Da Isoelectric Point: 4.2897

                                >NTDB_id=451171 HRE60_RS05530 WP_002891134.1 1150747..1151421(-) (ciaR) [Streptococcus salivarius strain DB-B5]

MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY

FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

Download Length: 675 bp

                                >NTDB_id=451171 HRE60_RS05530 WP_002891134.1 1150747..1151421(-) (ciaR) [Streptococcus salivarius strain DB-B5]

ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT

GATGCAAGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTAATTCTTTTAGACCTTATGT

TGCCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT

AAGGAAAGTCTAGACGATAAAGGACACGGCTTTGAACTAGGTGCAGATGACTATCTGACCAAACCTTTCTATTTAGAAGA

GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG

TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC

TTCTTGCAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT

ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTAAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA

GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	J7TS49

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362

Detailed information NTG0451171