Detailed information NTG0451168

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: HRE60_RS05250
• Genome accession: NZ_CP054153
• Coordinates: 1096984..1097823 (-)
• Length: 279 a.a.
• NCBI ID: WP_181670365.1
• Uniprot ID: A0A7L6WLD1
• Organism: Streptococcus salivarius strain DB-B5
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1091984..1102823

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HRE60_RS05235 (HRE60_05235)	-	1093036..1093695 (-)	660	WP_181670363.1	response regulator transcription factor	-
HRE60_RS05240 (HRE60_05240)	-	1093731..1094555 (-)	825	WP_181670364.1	TraX family protein	-
HRE60_RS05245 (HRE60_05245)	topA	1094672..1096816 (-)	2145	WP_004182436.1	type I DNA topoisomerase	-
HRE60_RS05250 (HRE60_05250)	dprA	1096984..1097823 (-)	840	WP_181670365.1	DNA-processing protein DprA	Machinery gene
HRE60_RS05255 (HRE60_05255)	-	1097890..1098810 (-)	921	WP_181670366.1	ROK family protein	-
HRE60_RS05260 (HRE60_05260)	-	1098817..1099587 (-)	771	WP_181670367.1	ribonuclease HII	-
HRE60_RS05265 (HRE60_05265)	ylqF	1099574..1100428 (-)	855	WP_014634567.1	ribosome biogenesis GTPase YlqF	-
HRE60_RS05270 (HRE60_05270)	-	1100557..1101246 (-)	690	WP_048675631.1	XRE family transcriptional regulator	-
HRE60_RS05275 (HRE60_05275)	-	1101341..1101856 (-)	516	WP_181670368.1	transcription repressor NadR	-
HRE60_RS05280 (HRE60_05280)	-	1101879..1102406 (-)	528	WP_022496664.1	ECF transporter S component	-

Sequence

Protein

• Length: 279 a.a.
• Molecular weight: 31250.17 Da
• Isoelectric Point: 8.4417

>NTDB_id=451168 HRE60_RS05250 WP_181670365.1 1096984..1097823(-) (dprA) [Streptococcus salivarius strain DB-B5]
MNNFELFKLKAAGLTNLNILNILDYQKTQDRKLSLRDMAVVSKSKNAVLFMEKYKSLDIKQLKEQFERFPTLSIFDKEYP
IELKYTYNPPVLLYYQGNLDLLSKPKLAVVGARKCSETGKQSVRKIVSELGNHFTIVSGLASGIDTCAHMEALKNKGNTI
AVIGTGLDVYYPKENKALQDYMAKNHLVLTEYGPGEQPLKYHFPERNRIISGLCQGVMVVEAKLRSGSLITCERAMEEGR
DVFAIPGNILDGKSDGCHHLIQEGAKCITTGFDILSEFS

Nucleotide

• Length: 840 bp

>NTDB_id=451168 HRE60_RS05250 WP_181670365.1 1096984..1097823(-) (dprA) [Streptococcus salivarius strain DB-B5]
ATGAATAATTTTGAACTTTTTAAACTTAAAGCCGCTGGGTTGACGAATTTGAATATCTTAAATATTTTGGACTATCAAAA
GACTCAAGATAGAAAATTGAGTTTACGTGATATGGCAGTGGTATCTAAGTCTAAAAATGCCGTTCTTTTTATGGAAAAGT
ATAAGAGTTTAGATATTAAGCAACTCAAAGAACAGTTTGAACGTTTTCCTACGTTATCGATTTTTGATAAAGAATATCCC
ATTGAGCTGAAGTATACCTATAATCCTCCTGTCCTCCTTTATTATCAGGGGAATCTTGATTTACTGAGTAAACCAAAGCT
AGCTGTTGTTGGGGCAAGAAAGTGTTCTGAAACAGGGAAACAGTCCGTTCGAAAAATTGTTAGTGAACTTGGTAATCACT
TTACTATTGTGAGTGGATTGGCTAGTGGGATTGATACTTGTGCGCATATGGAGGCCTTGAAAAATAAGGGGAACACTATT
GCAGTTATCGGGACCGGACTTGATGTTTATTATCCTAAAGAAAATAAAGCTTTGCAGGACTATATGGCCAAAAATCATTT
AGTTCTTACAGAATATGGACCGGGTGAACAGCCTCTCAAGTACCATTTTCCTGAACGTAATCGGATTATTTCTGGATTGT
GTCAAGGAGTTATGGTCGTAGAAGCAAAACTTCGCTCTGGAAGTCTGATTACTTGTGAGCGTGCCATGGAAGAAGGTAGA
GATGTTTTTGCTATTCCAGGAAATATTTTAGATGGAAAGTCAGACGGATGTCATCACTTAATTCAAGAGGGTGCAAAGTG
CATCACGACAGGGTTTGACATCCTATCAGAGTTTTCTTGA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (71-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A7L6WLD1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	71.685	100	0.717
dprA/cilB/dalA	Streptococcus mitis SK321	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae D39	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae R6	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	63.309	99.642	0.631
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	62.95	99.642	0.627
dprA	Lactococcus lactis subsp. cremoris KW2	59.712	99.642	0.595
dprA	Latilactobacillus sakei subsp. sakei 23K	40.927	92.832	0.38
dprA	Acinetobacter baylyi ADP1	41.085	92.473	0.38
dprA	Bacillus subtilis subsp. subtilis str. 168	48.571	75.269	0.366