Detailed information NTG0449919

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FOC73_RS01450
• Genome accession: NZ_CP053998
• Coordinates: 315042..315716 (-)
• Length: 224 a.a.
• NCBI ID: WP_004182019.1
• Uniprot ID: A0AAW6D9L9
• Organism: Streptococcus salivarius strain FDAARGOS_771
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 310042..320716

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOC73_RS01425 (FOC73_01425)	-	310350..311627 (-)	1278	WP_002885171.1	pyrimidine-nucleoside phosphorylase	-
FOC73_RS01430 (FOC73_01430)	-	311624..312214 (-)	591	WP_004182008.1	class I SAM-dependent methyltransferase	-
FOC73_RS01435 (FOC73_01435)	coaA	312327..313247 (+)	921	WP_004182102.1	type I pantothenate kinase	-
FOC73_RS01440 (FOC73_01440)	rpsT	313317..313553 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
FOC73_RS01445 (FOC73_01445)	ciaH	313637..315052 (-)	1416	WP_037604990.1	cell wall metabolism sensor histidine kinase WalK	Regulator
FOC73_RS01450 (FOC73_01450)	ciaR	315042..315716 (-)	675	WP_004182019.1	response regulator transcription factor	Regulator
FOC73_RS01455 (FOC73_01455)	-	315915..317585 (-)	1671	WP_004182072.1	formate--tetrahydrofolate ligase	-
FOC73_RS01460 (FOC73_01460)	-	317779..318462 (+)	684	WP_004182113.1	phosphopantothenate--cysteine ligase	-
FOC73_RS01465 (FOC73_01465)	coaC	318455..319000 (+)	546	WP_004182014.1	phosphopantothenoylcysteine decarboxylase	-
FOC73_RS01470 (FOC73_01470)	-	319029..319601 (+)	573	WP_004182105.1	ECF transporter S component	-
FOC73_RS01475 (FOC73_01475)	-	319668..320228 (+)	561	WP_004182060.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25392.04 Da
• Isoelectric Point: 4.2897

>NTDB_id=449919 FOC73_RS01450 WP_004182019.1 315042..315716(-) (ciaR) [Streptococcus salivarius strain FDAARGOS_771]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=449919 FOC73_RS01450 WP_004182019.1 315042..315716(-) (ciaR) [Streptococcus salivarius strain FDAARGOS_771]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACTTAATGT
TGCCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGAAAAGGGTGTAACAACCCCTGTACTAATCATGACGGCT
AAGGAAAGTCTAGACGATAAGGGACACGGCTTTGAACTGGGTGCAGATGACTACCTAACTAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAATACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGATCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTAGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTACCAATCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362