NTDB

Overview

Name	covR	Type	Regulator
Locus tag	HPC60_RS08410	Genome accession	NZ_CP053671
Coordinates	1708526..1709218 (-)	Length	230 a.a.
NCBI ID	WP_012898209.1	Uniprot ID	A0AAW7IPJ0
Organism	Lactococcus lactis subsp. lactis strain G121
Function	repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1703526..1714218

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HPC60_RS08395 (HPC60_03135)	-	1705146..1705487 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
HPC60_RS08400 (HPC60_03140)	-	1705619..1706860 (-)	1242	WP_023188702.1	ammonium transporter	-
HPC60_RS08405 (HPC60_03145)	covS	1707043..1708518 (-)	1476	WP_010906048.1	HAMP domain-containing histidine kinase	Regulator
HPC60_RS08410 (HPC60_03150)	covR	1708526..1709218 (-)	693	WP_012898209.1	response regulator transcription factor	Regulator
HPC60_RS08415 (HPC60_03155)	-	1709374..1709904 (-)	531	WP_012898210.1	DUF177 domain-containing protein	-
HPC60_RS08420 (HPC60_03160)	-	1710035..1710280 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
HPC60_RS08425 (HPC60_03165)	-	1710436..1710900 (-)	465	WP_023188701.1	hypothetical protein	-
HPC60_RS08430 (HPC60_03170)	-	1710982..1711344 (-)	363	WP_023188700.1	TIGR02328 family protein	-
HPC60_RS08435 (HPC60_03175)	-	1711570..1712481 (-)	912	WP_023188699.1	CHAP domain-containing protein	-
HPC60_RS08440 (HPC60_03180)	-	1712594..1713430 (-)	837	WP_025017008.1	metallophosphoesterase	-

Sequence

Protein

Download Length: 230 a.a. Molecular weight: 26670.33 Da Isoelectric Point: 5.1273

                                >NTDB_id=446197 HPC60_RS08410 WP_012898209.1 1708526..1709218(-) (covR) [Lactococcus lactis subsp. lactis strain G121]

MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEASSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM

TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE

YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

Download Length: 693 bp

                                >NTDB_id=446197 HPC60_RS08410 WP_012898209.1 1708526..1709218(-) (covR) [Lactococcus lactis subsp. lactis strain G121]

ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG

CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAAGTTCAAAAGATTATGATTTAATCTTGCTTG

ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCTCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG

ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT

TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT

CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG

TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA

TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA

GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)

Response regulator receiver domain (Response_reg)

(6-115)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361

Detailed information NTG0446197