Detailed information NTG0445893

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HA036_RS13660
• Genome accession: NZ_CP053639
• Coordinates: 2722209..2723252 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 14732
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2717209..2728252

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HA036_RS13630 (HA036_13650)	-	2717627..2718883 (-)	1257	WP_001795438.1	aminopeptidase	-
HA036_RS13635 (HA036_13655)	-	2718886..2719086 (-)	201	WP_000180461.1	DUF1128 family protein	-
HA036_RS13640 (HA036_13660)	-	2719233..2719697 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HA036_RS13645 (HA036_13665)	-	2719704..2719979 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HA036_RS13650 (HA036_13670)	-	2720257..2721474 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
HA036_RS13655 (HA036_13675)	vraR	2721590..2722219 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
HA036_RS13660 (HA036_13680)	vraS	2722209..2723252 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HA036_RS13665 (HA036_13685)	liaF	2723249..2723950 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HA036_RS13670 (HA036_13690)	-	2723965..2724351 (-)	387	WP_001110179.1	hypothetical protein	-
HA036_RS13675 (HA036_13695)	map	2724568..2725326 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HA036_RS13680 (HA036_13700)	-	2725913..2726899 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
HA036_RS13685 (HA036_13705)	-	2727330..2727743 (-)	414	WP_001549145.1	hypothetical protein	-
HA036_RS13690 (HA036_13710)	-	2727772..2727882 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=445893 HA036_RS13660 WP_001017131.1 2722209..2723252(-) (vraS) [Staphylococcus aureus strain 14732]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=445893 HA036_RS13660 WP_001017131.1 2722209..2723252(-) (vraS) [Staphylococcus aureus strain 14732]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1