Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   MGAS15252_RS04590 Genome accession   NC_017040
Coordinates   930573..931247 (-) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS15252     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 925573..936247
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS15252_RS04565 (MGAS15252_0940) - 926020..926409 (-) 390 WP_011285547.1 cytidine deaminase -
  MGAS15252_RS04570 (MGAS15252_0941) - 927062..927655 (-) 594 WP_014407608.1 class I SAM-dependent methyltransferase -
  MGAS15252_RS04575 (MGAS15252_0942) coaA 927923..928843 (+) 921 WP_014407609.1 type I pantothenate kinase -
  MGAS15252_RS04580 (MGAS15252_0943) rpsT 928897..929145 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  MGAS15252_RS04585 (MGAS15252_0944) ciaH 929270..930580 (-) 1311 WP_011184551.1 sensor histidine kinase Regulator
  MGAS15252_RS04590 (MGAS15252_0945) ciaR 930573..931247 (-) 675 WP_002984519.1 response regulator transcription factor Regulator
  MGAS15252_RS04595 (MGAS15252_0946) - 931594..934131 (-) 2538 WP_014407610.1 M1 family metallopeptidase -
  MGAS15252_RS04600 (MGAS15252_0947) phoU 934336..934989 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  MGAS15252_RS04605 (MGAS15252_0948) pstB 935057..935815 (-) 759 WP_041174337.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=44403 MGAS15252_RS04590 WP_002984519.1 930573..931247(-) (ciaR) [Streptococcus pyogenes MGAS15252]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=44403 MGAS15252_RS04590 WP_002984519.1 930573..931247(-) (ciaR) [Streptococcus pyogenes MGAS15252]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACCAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGATATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment