Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYB   Type   Machinery gene
Locus tag   MGAS15252_RS00585 Genome accession   NC_017040
Coordinates   96748..97782 (+) Length   344 a.a.
NCBI ID   WP_227868709.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS15252     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 91748..102782
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS15252_RS00575 (MGAS15252_0119) - 95430..95795 (+) 366 WP_002986560.1 DUF1033 family protein -
  MGAS15252_RS00580 (MGAS15252_0120) comGA 95888..96812 (+) 925 Protein_81 competence type IV pilus ATPase ComGA -
  MGAS15252_RS00585 (MGAS15252_0121) comYB 96748..97782 (+) 1035 WP_227868709.1 competence type IV pilus assembly protein ComGB Machinery gene
  MGAS15252_RS00590 (MGAS15252_0122) comGC 97784..98110 (+) 327 WP_014407214.1 competence type IV pilus major pilin ComGC Machinery gene
  MGAS15252_RS00595 (MGAS15252_0123) comGD 98085..98513 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  MGAS15252_RS00600 (MGAS15252_0124) comGE 98470..98754 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  MGAS15252_RS00605 (MGAS15252_0125) comYF 98747..99181 (+) 435 WP_014407215.1 competence type IV pilus minor pilin ComGF Machinery gene
  MGAS15252_RS00610 (MGAS15252_0126) comGG 99165..99491 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  MGAS15252_RS00615 (MGAS15252_0127) comYH 99589..100542 (+) 954 WP_014407216.1 class I SAM-dependent methyltransferase Machinery gene
  MGAS15252_RS00620 (MGAS15252_0128) - 100601..101797 (+) 1197 WP_014407217.1 acetate kinase -
  MGAS15252_RS00625 (MGAS15252_0129) - 101984..102292 (+) 309 WP_041174321.1 hypothetical protein -

Sequence

Protein


Download         Length: 344 a.a.        Molecular weight: 39704.20 Da        Isoelectric Point: 9.7085

>NTDB_id=44377 MGAS15252_RS00585 WP_227868709.1 96748..97782(+) (comYB) [Streptococcus pyogenes MGAS15252]
MISFLRQDISIPSKLSLKKLSSKHQHKFIQLLANLLSTGFSFVEVIAFLKRSQLLQLDYVLKMEESLLKGQGLADMLSGL
GFSDAILTQISLADRHGNIETTLVAIQHYLNQMARIRRKTVEVITYPLILLLFLFVMMLGLRRYLVPQLETQNQITYFLN
HFPAFFIGFCSGLILLFGMVWLRWRSQSRLKLYSRLSRYPFLGKLLKQYLTSYYAREWGTLIGQGLDLMTILDIMAIEKS
SLMKELAEDIRMSLLEGQAFHIKVATYPFFKKELSLMIEYGEIKSKLGAELEIYAQESWEQFFSQLYQVTQLIQPAIFLV
VAVTIVMIYAAILLPIYQNMGGIF

Nucleotide


Download         Length: 1035 bp        

>NTDB_id=44377 MGAS15252_RS00585 WP_227868709.1 96748..97782(+) (comYB) [Streptococcus pyogenes MGAS15252]
TTGATCAGCTTTTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAGTAAACATCAGCATAA
ATTCATTCAATTACTAGCTAATCTTTTATCTACAGGATTTAGCTTCGTAGAGGTTATTGCTTTTTTAAAAAGAAGCCAGT
TGCTTCAGCTAGATTATGTTCTTAAAATGGAAGAGTCTTTATTAAAAGGACAAGGCTTAGCAGATATGTTGTCGGGTTTA
GGTTTTTCAGATGCTATTCTTACTCAAATTAGTTTAGCTGATAGACACGGTAATATTGAAACAACATTAGTAGCGATTCA
ACATTACTTGAACCAAATGGCAAGGATCAGACGAAAAACTGTTGAAGTTATCACCTATCCTCTTATTCTTTTACTTTTTC
TTTTTGTGATGATGCTAGGGTTGAGACGCTATTTAGTCCCTCAATTAGAAACTCAAAATCAGATAACTTACTTTCTTAAC
CATTTTCCTGCCTTCTTTATAGGTTTTTGCTCAGGTCTTATTTTGTTGTTCGGGATGGTATGGCTACGATGGCGATCTCA
AAGCCGCTTGAAACTCTATAGTCGGCTAAGCCGTTATCCTTTTTTAGGTAAACTGTTAAAACAATACTTAACTAGTTATT
ATGCTAGAGAATGGGGTACGTTAATAGGTCAAGGTCTTGATTTGATGACTATTTTAGACATTATGGCCATTGAGAAATCC
TCACTAATGAAAGAATTAGCTGAGGACATCAGAATGAGTCTGCTTGAAGGGCAAGCCTTTCACATTAAAGTAGCTACCTA
CCCTTTTTTTAAAAAAGAATTAAGTTTAATGATTGAATACGGTGAAATCAAATCGAAACTGGGGGCTGAGTTGGAAATCT
ATGCCCAGGAAAGCTGGGAACAATTTTTTAGTCAGCTTTATCAAGTGACACAACTTATTCAACCAGCTATTTTTTTAGTA
GTTGCTGTGACAATCGTCATGATTTATGCGGCAATCCTATTACCAATTTACCAAAATATGGGAGGTATTTTTTAA

Domains

Predicted by InterproScan.

Type II secretion system (T2SS), protein F (T2SSF)

(215-335)

Type II secretion system (T2SS), protein F (T2SSF)

(28-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYB Streptococcus mutans UA140

53.982

98.547

0.532
  comYB Streptococcus mutans UA159

53.982

98.547

0.532
  comYB Streptococcus gordonii str. Challis substr. CH1

50.294

98.837

0.497
  comGB/cglB Streptococcus mitis NCTC 12261

47.917

97.674

0.468
  comGB/cglB Streptococcus mitis SK321

48.048

96.802

0.465
  comGB/cglB Streptococcus pneumoniae Rx1

45.946

96.802

0.445
  comGB/cglB Streptococcus pneumoniae D39

45.946

96.802

0.445
  comGB/cglB Streptococcus pneumoniae R6

45.946

96.802

0.445
  comGB/cglB Streptococcus pneumoniae TIGR4

45.946

96.802

0.445
  comGB Lactococcus lactis subsp. cremoris KW2

42.769

94.477

0.404

Multiple sequence alignment