Detailed information NTG0044379

Bioinformatically predicted

Overview

• Name: comYF
• Type: Machinery gene
• Locus tag: MGAS15252_RS00605
• Genome accession: NC_017040
• Coordinates: 98747..99181 (+)
• Length: 144 a.a.
• NCBI ID: WP_014407215.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes MGAS15252
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 93747..104181

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS15252_RS00575 (MGAS15252_0119)	-	95430..95795 (+)	366	WP_002986560.1	DUF1033 family protein	-
MGAS15252_RS00580 (MGAS15252_0120)	comGA	95888..96812 (+)	925	Protein_81	competence type IV pilus ATPase ComGA	-
MGAS15252_RS00585 (MGAS15252_0121)	comYB	96748..97782 (+)	1035	WP_227868709.1	competence type IV pilus assembly protein ComGB	Machinery gene
MGAS15252_RS00590 (MGAS15252_0122)	comGC	97784..98110 (+)	327	WP_014407214.1	competence type IV pilus major pilin ComGC	Machinery gene
MGAS15252_RS00595 (MGAS15252_0123)	comGD	98085..98513 (+)	429	WP_002986548.1	competence type IV pilus minor pilin ComGD	-
MGAS15252_RS00600 (MGAS15252_0124)	comGE	98470..98754 (+)	285	WP_002987779.1	competence type IV pilus minor pilin ComGE	-
MGAS15252_RS00605 (MGAS15252_0125)	comYF	98747..99181 (+)	435	WP_014407215.1	competence type IV pilus minor pilin ComGF	Machinery gene
MGAS15252_RS00610 (MGAS15252_0126)	comGG	99165..99491 (+)	327	WP_010921801.1	competence type IV pilus minor pilin ComGG	-
MGAS15252_RS00615 (MGAS15252_0127)	comYH	99589..100542 (+)	954	WP_014407216.1	class I SAM-dependent methyltransferase	Machinery gene
MGAS15252_RS00620 (MGAS15252_0128)	-	100601..101797 (+)	1197	WP_014407217.1	acetate kinase	-
MGAS15252_RS00625 (MGAS15252_0129)	-	101984..102292 (+)	309	WP_041174321.1	hypothetical protein	-
MGAS15252_RS00630 (MGAS15252_0130)	proC	102375..103145 (-)	771	WP_014407219.1	pyrroline-5-carboxylate reductase	-

Sequence

Protein

• Length: 144 a.a.
• Molecular weight: 16542.20 Da
• Isoelectric Point: 10.0827

>NTDB_id=44379 MGAS15252_RS00605 WP_014407215.1 98747..99181(+) (comYF) [Streptococcus pyogenes MGAS15252]
MSKQLSNIKAFTLLEALIALLVISGSLLVYQGLTQTLLKRSHYLALHDQDNWLLFSHQLREELSGARFCKVADNKLYVEK
GKKVLAFGQFKSHDFRKSASNGKGYQPMLFGISRSHIHIEQSQICITLKWKSGLERTFYYAFQD

Nucleotide

• Length: 435 bp

>NTDB_id=44379 MGAS15252_RS00605 WP_014407215.1 98747..99181(+) (comYF) [Streptococcus pyogenes MGAS15252]
TTGAGTAAACAATTAAGTAACATAAAAGCTTTTACCCTTCTAGAGGCGTTAATAGCCTTACTTGTGATATCAGGGTCTTT
ATTGGTTTATCAAGGTTTGACCCAAACCCTCCTTAAACGTAGCCATTATCTAGCCCTTCATGATCAAGACAATTGGCTCT
TATTTTCTCATCAATTGCGAGAGGAGTTAAGTGGAGCAAGATTTTGCAAAGTAGCTGATAATAAACTATACGTTGAAAAA
GGAAAGAAAGTACTAGCTTTTGGCCAATTTAAAAGTCATGATTTTCGAAAATCAGCTAGTAATGGAAAAGGATATCAACC
CATGTTATTTGGAATATCACGTAGTCATATTCACATAGAGCAGTCACAGATTTGCATTACTTTAAAGTGGAAAAGTGGGT
TAGAAAGGACTTTTTATTATGCCTTTCAAGACTAA

Domains

Predicted by InterproScan.

• Putative Competence protein ComGF (ComGF) (47-135)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYF	Streptococcus mutans UA140	51.079	96.528	0.493
comYF	Streptococcus mutans UA159	50.36	96.528	0.486
comGF	Lactococcus lactis subsp. cremoris KW2	46.715	95.139	0.444
comGF/cglF	Streptococcus mitis NCTC 12261	44.776	93.056	0.417
comGF/cglF	Streptococcus pneumoniae Rx1	43.609	92.361	0.403
comGF/cglF	Streptococcus pneumoniae D39	43.609	92.361	0.403
comGF/cglF	Streptococcus pneumoniae R6	43.609	92.361	0.403
comGF/cglF	Streptococcus pneumoniae TIGR4	43.609	92.361	0.403
comGF/cglF	Streptococcus mitis SK321	42.857	92.361	0.396