Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   HKM25_RS03515 Genome accession   NZ_CP053210
Coordinates   691995..692585 (+) Length   196 a.a.
NCBI ID   WP_000613477.1    Uniprot ID   A0A064BX72
Organism   Streptococcus pneumoniae strain 6A-10     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 686610..704872 691995..692585 within 0


Gene organization within MGE regions


Location: 686610..704872
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HKM25_RS03480 (HKM25_715) - 686610..686966 (-) 357 Protein_699 NAD(P)/FAD-dependent oxidoreductase -
  HKM25_RS03485 (HKM25_716) - 687225..688178 (+) 954 WP_001155321.1 IS30-like element ISSpn8 family transposase -
  HKM25_RS03490 - 688198..689031 (-) 834 Protein_701 aminoacetone oxidase family FAD-binding enzyme -
  HKM25_RS03495 (HKM25_717) - 689090..689935 (-) 846 WP_000219939.1 DegV family protein -
  HKM25_RS03500 (HKM25_718) - 690060..690617 (+) 558 WP_000004148.1 TetR/AcrR family transcriptional regulator -
  HKM25_RS03505 (HKM25_719) - 690636..691103 (+) 468 WP_000136976.1 cytidine/deoxycytidylate deaminase family protein -
  HKM25_RS03510 (HKM25_720) upp 691192..691821 (+) 630 WP_000515974.1 uracil phosphoribosyltransferase -
  HKM25_RS03515 (HKM25_721) clpP 691995..692585 (+) 591 WP_000613477.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  HKM25_RS03520 (HKM25_722) - 692664..692912 (+) 249 WP_000462126.1 YlbG family protein -
  HKM25_RS03525 (HKM25_723) - 693013..694173 (+) 1161 WP_000726146.1 ABC transporter substrate-binding protein -
  HKM25_RS03530 (HKM25_724) - 694441..695310 (+) 870 WP_000941424.1 branched-chain amino acid ABC transporter permease -
  HKM25_RS03535 (HKM25_725) - 695314..696270 (+) 957 WP_000662298.1 branched-chain amino acid ABC transporter permease -
  HKM25_RS03540 (HKM25_726) - 696270..697034 (+) 765 WP_001186003.1 ABC transporter ATP-binding protein -
  HKM25_RS03545 (HKM25_727) - 697034..697744 (+) 711 WP_000062223.1 ABC transporter ATP-binding protein -
  HKM25_RS03550 (HKM25_728) - 698052..698708 (+) 657 WP_000268677.1 CBS domain-containing protein -
  HKM25_RS03555 (HKM25_729) prfB 698816..699911 (+) 1096 WP_015511312.1 peptide chain release factor 2 -
  HKM25_RS03560 (HKM25_730) ftsE 699929..700621 (+) 693 WP_000022265.1 cell division ATP-binding protein FtsE -
  HKM25_RS03565 (HKM25_731) ftsX 700614..701540 (+) 927 WP_000625537.1 permease-like cell division protein FtsX -
  HKM25_RS03570 (HKM25_732) - 701825..704005 (+) 2181 WP_000974079.1 PTS transporter subunit IIBC -
  HKM25_RS03575 (HKM25_733) - 704057..704872 (+) 816 WP_000670830.1 endonuclease/exonuclease/phosphatase family protein -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 21358.36 Da        Isoelectric Point: 4.4910

>NTDB_id=443430 HKM25_RS03515 WP_000613477.1 691995..692585(+) (clpP) [Streptococcus pneumoniae strain 6A-10]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Nucleotide


Download         Length: 591 bp        

>NTDB_id=443430 HKM25_RS03515 WP_000613477.1 691995..692585(+) (clpP) [Streptococcus pneumoniae strain 6A-10]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACGAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGGACTGTCATCGCATCAAGTGGGGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(11-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064BX72

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae Rx1

100

100

1
  clpP Streptococcus pneumoniae D39

100

100

1
  clpP Streptococcus pneumoniae R6

100

100

1
  clpP Streptococcus pneumoniae TIGR4

100

100

1
  clpP Streptococcus thermophilus LMG 18311

92.821

99.49

0.923
  clpP Streptococcus thermophilus LMD-9

92.821

99.49

0.923
  clpP Streptococcus pyogenes JRS4

90.769

99.49

0.903
  clpP Streptococcus pyogenes MGAS315

90.769

99.49

0.903
  clpP Streptococcus mutans UA159

85.714

100

0.857
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

85.128

99.49

0.847
  clpP Lactococcus lactis subsp. cremoris KW2

84.615

99.49

0.842
  clpP Bacillus subtilis subsp. subtilis str. 168

58.854

97.959

0.577
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.031

98.469

0.571