Detailed information NTG0443427

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: HKM25_RS02590
• Genome accession: NZ_CP053210
• Coordinates: 498734..500887 (-)
• Length: 717 a.a.
• NCBI ID: WP_000205152.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 6A-10
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 493734..505887

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HKM25_RS02560 (HKM25_521)	-	494067..494396 (-)	330	WP_000132575.1	hypothetical protein	-
HKM25_RS02565 (HKM25_522)	-	494672..495010 (+)	339	WP_000682133.1	LytTR family DNA-binding domain-containing protein	-
HKM25_RS02570 (HKM25_523)	comE/blpR	495015..495752 (+)	738	WP_001219122.1	LytTR family DNA-binding domain-containing protein	Regulator
HKM25_RS02575 (HKM25_524)	-	495765..497105 (+)	1341	WP_000275285.1	sensor histidine kinase	-
HKM25_RS02580	blpC	497150..497305 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
HKM25_RS02585 (HKM25_525)	-	497362..498723 (-)	1362	WP_001069099.1	bacteriocin secretion accessory protein	-
HKM25_RS02590 (HKM25_526)	comA/nlmT	498734..500887 (-)	2154	WP_000205152.1	peptide cleavage/export ABC transporter BlpA	Regulator
HKM25_RS02595 (HKM25_527)	blpM	501169..501423 (+)	255	WP_001093255.1	two-peptide bacteriocin subunit BlpM	-
HKM25_RS02600 (HKM25_528)	blpN	501439..501642 (+)	204	WP_001099490.1	two-peptide bacteriocin subunit BlpN	-
HKM25_RS02605 (HKM25_529)	cipB	501886..502035 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
HKM25_RS02610 (HKM25_531)	-	502139..502258 (+)	120	WP_001829206.1	PncF family bacteriocin immunity protein	-
HKM25_RS11995	-	502947..503943 (+)	997	Protein_522	thioredoxin domain-containing protein	-
HKM25_RS12000	-	504400..504593 (+)	194	Protein_523	hypothetical protein	-
HKM25_RS02625 (HKM25_535)	-	504676..505095 (+)	420	WP_000877382.1	hypothetical protein	-
HKM25_RS02630 (HKM25_536)	-	505110..505799 (+)	690	WP_000760515.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80780.77 Da
• Isoelectric Point: 7.4327

>NTDB_id=443427 HKM25_RS02590 WP_000205152.1 498734..500887(-) (comA/nlmT) [Streptococcus pneumoniae strain 6A-10]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEEKLQHYYVVYQTKKDYLVIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQAPENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILKACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLISLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide

• Length: 2154 bp

>NTDB_id=443427 HKM25_RS02590 WP_000205152.1 498734..500887(-) (comA/nlmT) [Streptococcus pneumoniae strain 6A-10]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGCGGTGTTGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGAACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACTCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGAAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGGTTATTGGTGATCCTGACCCTTCTGTAAAAATCACCAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTTCTTA
TTATCTCCAAGGAATCTTAGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTTTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTCCTTTCTCTTCTTTCCATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAACCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACGAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTTG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAGTCTGAGTTCCAAGCCCCAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TCGAACCCTACAAAGGGCATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCCCAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAACTTAACCTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAAAGCTTGTGAATTAGCTGAAATTCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATCGCTCTCGCTCGTGCTCTTTTAACTAAAGCTCCT
GTTTTAATACTAGATGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATATCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACTAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (169-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	71.888	99.721	0.717
comA	Streptococcus mitis NCTC 12261	66.339	99.442	0.66
comA	Streptococcus pneumoniae Rx1	66.059	99.442	0.657
comA	Streptococcus pneumoniae D39	66.059	99.442	0.657
comA	Streptococcus pneumoniae R6	66.059	99.442	0.657
comA	Streptococcus mitis SK321	65.778	99.442	0.654
comA	Streptococcus pneumoniae TIGR4	65.778	99.442	0.654
comA	Streptococcus gordonii str. Challis substr. CH1	65.042	100	0.651