Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   HKM25_RS02570 Genome accession   NZ_CP053210
Coordinates   495015..495752 (+) Length   245 a.a.
NCBI ID   WP_001219122.1    Uniprot ID   A0A0I5XJR5
Organism   Streptococcus pneumoniae strain 6A-10     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 490015..500752
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HKM25_RS02535 (HKM25_516) - 490946..491185 (-) 240 WP_001813906.1 hypothetical protein -
  HKM25_RS02540 (HKM25_517) - 491347..491634 (-) 288 WP_000777760.1 hypothetical protein -
  HKM25_RS02545 (HKM25_518) - 491644..492054 (-) 411 WP_001278301.1 HIT family protein -
  HKM25_RS02550 (HKM25_519) pptA 492122..492853 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  HKM25_RS02555 (HKM25_520) - 492850..493899 (+) 1050 WP_000653767.1 ABC transporter permease -
  HKM25_RS02560 (HKM25_521) - 494067..494396 (-) 330 WP_000132575.1 hypothetical protein -
  HKM25_RS02565 (HKM25_522) - 494672..495010 (+) 339 WP_000682133.1 LytTR family DNA-binding domain-containing protein -
  HKM25_RS02570 (HKM25_523) comE/blpR 495015..495752 (+) 738 WP_001219122.1 LytTR family DNA-binding domain-containing protein Regulator
  HKM25_RS02575 (HKM25_524) - 495765..497105 (+) 1341 WP_000275285.1 sensor histidine kinase -
  HKM25_RS02580 blpC 497150..497305 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  HKM25_RS02585 (HKM25_525) - 497362..498723 (-) 1362 WP_001069099.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28766.95 Da        Isoelectric Point: 6.4140

>NTDB_id=443426 HKM25_RS02570 WP_001219122.1 495015..495752(+) (comE/blpR) [Streptococcus pneumoniae strain 6A-10]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=443426 HKM25_RS02570 WP_001219122.1 495015..495752(+) (comE/blpR) [Streptococcus pneumoniae strain 6A-10]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0I5XJR5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38