Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   HHM66_RS02290 Genome accession   NZ_CP053074
Coordinates   431837..432427 (+) Length   196 a.a.
NCBI ID   WP_002985850.1    Uniprot ID   A0A9X8T4H8
Organism   Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A88     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 425503..440270 431837..432427 within 0


Gene organization within MGE regions


Location: 425503..440270
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HHM66_RS02265 (HHM66_02270) - 425503..426285 (-) 783 WP_170078131.1 ABC transporter ATP-binding protein -
  HHM66_RS02270 (HHM66_02275) - 426534..427979 (-) 1446 WP_003062496.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase -
  HHM66_RS02275 (HHM66_02280) - 428067..429701 (+) 1635 WP_015057354.1 polysaccharide biosynthesis protein -
  HHM66_RS02280 (HHM66_02285) - 429687..430772 (-) 1086 WP_015057355.1 IS30 family transposase -
  HHM66_RS02285 (HHM66_02290) upp 430986..431615 (+) 630 WP_003058279.1 uracil phosphoribosyltransferase -
  HHM66_RS02290 (HHM66_02295) clpP 431837..432427 (+) 591 WP_002985850.1 ATP-dependent Clp protease proteolytic subunit Regulator
  HHM66_RS02295 (HHM66_02300) - 432823..433119 (+) 297 WP_014612054.1 DUF4298 domain-containing protein -
  HHM66_RS02300 (HHM66_02305) - 433194..433664 (+) 471 WP_014612055.1 YlbF family regulator -
  HHM66_RS02305 (HHM66_02310) - 433640..433930 (+) 291 WP_003060978.1 YlbG family protein -
  HHM66_RS02310 (HHM66_02315) - 434179..435351 (+) 1173 WP_003058679.1 ABC transporter substrate-binding protein -
  HHM66_RS02315 (HHM66_02320) - 435540..436409 (+) 870 WP_015057356.1 branched-chain amino acid ABC transporter permease -
  HHM66_RS02320 (HHM66_02325) - 436413..437366 (+) 954 WP_003062562.1 branched-chain amino acid ABC transporter permease -
  HHM66_RS02325 (HHM66_02330) - 437367..438131 (+) 765 WP_003058688.1 ABC transporter ATP-binding protein -
  HHM66_RS02330 (HHM66_02335) - 438137..438841 (+) 705 WP_170172086.1 ABC transporter ATP-binding protein -
  HHM66_RS02335 (HHM66_02340) - 438886..439548 (+) 663 WP_003058678.1 CBS domain-containing protein -
  HHM66_RS02340 (HHM66_02345) tmk 439635..440270 (+) 636 WP_003058667.1 dTMP kinase -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 21648.88 Da        Isoelectric Point: 5.2834

>NTDB_id=442767 HHM66_RS02290 WP_002985850.1 431837..432427(+) (clpP) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A88]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK

Nucleotide


Download         Length: 591 bp        

>NTDB_id=442767 HHM66_RS02290 WP_002985850.1 431837..432427(+) (clpP) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A88]
ATGATTCCTGTTGTTATTGAACAAACTAGTCGTGGTGAACGTTCTTATGACATTTACTCACGCTTATTAAAAGACCGTAT
TATCATGTTGACAGGCCCTGTTGAGGACAACATGGCAAACTCTGTCATTGCGCAGCTTTTATTCCTTGATGCTCAGGACA
ATACGAAAGACATTTATTTGTATGTCAACACACCTGGTGGTTCTGTTTCAGCGGGTTTGGCTATTGTCGACACCATGAAC
TTTATCAAAGCTGATGTCCAAACCATTGTTATGGGGATGGCCGCTTCTATGGGGACTGTCATTGCTTCATCAGGTACTAA
GGGCAAACGCTTCATGTTACCAAATGCAGAATACATGATTCACCAACCAATGGGTGGTACAGGTGGTGGTACACAACAAA
CAGATATGGCCATTGCTGCAGAGCACCTCTTAAAAACTCGTCACCGTTTAGAAAAAATCTTAGCACAAAATGCTGGAAAG
ACCATTAAACAAATTCACAAAGATGCTGAACGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAATAACGAATTAAAATAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(11-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pyogenes MGAS315

100

100

1
  clpP Streptococcus pyogenes JRS4

100

100

1
  clpP Streptococcus mutans UA159

90.816

100

0.908
  clpP Streptococcus pneumoniae Rx1

90.769

99.49

0.903
  clpP Streptococcus pneumoniae D39

90.769

99.49

0.903
  clpP Streptococcus pneumoniae R6

90.769

99.49

0.903
  clpP Streptococcus pneumoniae TIGR4

90.769

99.49

0.903
  clpP Streptococcus thermophilus LMG 18311

89.796

100

0.898
  clpP Streptococcus thermophilus LMD-9

89.796

100

0.898
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

86.224

100

0.862
  clpP Lactococcus lactis subsp. cremoris KW2

85.714

100

0.857
  clpP Bacillus subtilis subsp. subtilis str. 168

57.143

100

0.571
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

56.995

98.469

0.561