Detailed information NTG0438852

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HGO94_RS00465
• Genome accession: NZ_CP051483
• Coordinates: 81917..82960 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NGA66a
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76917..87960

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HGO94_RS00435 (HGO94_11425)	-	77283..77394 (+)	112	Protein_86	hypothetical protein	-
HGO94_RS00440 (HGO94_11430)	-	77423..77836 (+)	414	WP_001837236.1	hypothetical protein	-
HGO94_RS00445 (HGO94_11435)	-	78326..79312 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
HGO94_RS00450 (HGO94_11440)	map	79843..80601 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HGO94_RS00455 (HGO94_11445)	-	80818..81204 (+)	387	WP_001110179.1	hypothetical protein	-
HGO94_RS00460 (HGO94_11450)	liaF	81219..81920 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HGO94_RS00465 (HGO94_11455)	vraS	81917..82960 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HGO94_RS00470 (HGO94_11460)	vraR	82950..83579 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
HGO94_RS00475 (HGO94_11465)	-	83691..84902 (-)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
HGO94_RS00480 (HGO94_11470)	-	85180..85455 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
HGO94_RS00485 (HGO94_11475)	-	85462..85926 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HGO94_RS00490 (HGO94_11480)	-	86073..86273 (+)	201	WP_078153768.1	DUF1128 family protein	-
HGO94_RS00495 (HGO94_11485)	-	86276..87532 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=438852 HGO94_RS00465 WP_001017131.1 81917..82960(+) (vraS) [Staphylococcus aureus strain NGA66a]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=438852 HGO94_RS00465 WP_001017131.1 81917..82960(+) (vraS) [Staphylococcus aureus strain NGA66a]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1