Detailed information NTG0435348

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: HEQ84_RS01455
• Genome accession: NZ_CP050870
• Coordinates: 260624..261523 (+)
• Length: 299 a.a.
• NCBI ID: WP_014607953.1
• Uniprot ID: A0AAN1ZWJ0
• Organism: Streptococcus thermophilus strain CS6
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 255624..266523

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HEQ84_RS01435 (HEQ84_01425)	trkA	256760..258109 (-)	1350	WP_024704181.1	Trk system potassium transporter TrkA	-
HEQ84_RS01440 (HEQ84_01430)	-	258399..258908 (+)	510	WP_024704182.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
HEQ84_RS01445 (HEQ84_01435)	-	259219..259776 (+)	558	WP_024704183.1	ECF transporter S component	-
HEQ84_RS01450 (HEQ84_01440)	-	259779..260429 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
HEQ84_RS01455 (HEQ84_01445)	comR	260624..261523 (+)	900	WP_014607953.1	helix-turn-helix domain-containing protein	Regulator
HEQ84_RS01460	-	261761..262192 (+)	432	Protein_235	cysteine peptidase family C39 domain-containing protein	-
HEQ84_RS01465	-	262222..262938 (+)	717	Protein_236	ABC transporter transmembrane domain-containing protein	-
HEQ84_RS01470	comA	262960..263169 (+)	210	WP_002946147.1	hypothetical protein	Regulator
HEQ84_RS01475 (HEQ84_01465)	-	263224..263792 (+)	569	Protein_238	ATP-binding cassette domain-containing protein	-
HEQ84_RS01480 (HEQ84_01470)	-	263900..264232 (+)	333	WP_024704184.1	DUF805 domain-containing protein	-
HEQ84_RS01485	-	264378..264857 (-)	480	WP_224107489.1	DUF4153 domain-containing protein	-
HEQ84_RS01490	-	265299..265670 (-)	372	WP_224107488.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35289.70 Da
• Isoelectric Point: 5.0061

>NTDB_id=435348 HEQ84_RS01455 WP_014607953.1 260624..261523(+) (comR) [Streptococcus thermophilus strain CS6]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=435348 HEQ84_RS01455 WP_014607953.1 260624..261523(+) (comR) [Streptococcus thermophilus strain CS6]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	98.997	100	0.99
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418