Detailed information NTG0430588

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: HA248_RS11795
• Genome accession: NZ_CP050175
• Coordinates: 501558..502145 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PZ900701590
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 496558..507145

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HA248_RS02575 (HA248_02570)	-	497019..498359 (+)	1341	WP_000275285.1	sensor histidine kinase	-
HA248_RS02580 (HA248_02575)	blpC	498404..498559 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
HA248_RS02585 (HA248_02580)	-	498616..499977 (-)	1362	WP_033705510.1	bacteriocin secretion accessory protein	-
HA248_RS02590 (HA248_02585)	comA/nlmT	499988..501664 (-)	1677	WP_317830619.1	peptide cleavage/export ABC transporter	Regulator
HA248_RS11795	comA/nlmT	501558..502145 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
HA248_RS02600 (HA248_02590)	blpM	502484..502738 (+)	255	WP_033705509.1	two-peptide bacteriocin subunit BlpM	-
HA248_RS02605 (HA248_02595)	blpN	502754..502957 (+)	204	WP_001099490.1	two-peptide bacteriocin subunit BlpN	-
HA248_RS02610 (HA248_02600)	cipB	503201..503350 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
HA248_RS02615 (HA248_02605)	-	503454..503573 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
HA248_RS02620 (HA248_02610)	-	504093..504412 (+)	320	Protein_513	immunity protein	-
HA248_RS02625 (HA248_02615)	-	504573..505542 (+)	970	Protein_514	thioredoxin domain-containing protein	-
HA248_RS02630 (HA248_02620)	-	505789..506022 (+)	234	WP_033705506.1	bacteriocin class II family protein	-
HA248_RS02635 (HA248_02625)	-	506054..506743 (+)	690	WP_033705505.1	CPBP family intramembrane glutamic endopeptidase	-
HA248_RS02640 (HA248_02630)	blpZ	506785..507033 (+)	249	WP_000276506.1	immunity protein BlpZ	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=430588 HA248_RS11795 WP_000205166.1 501558..502145(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900701590]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=430588 HA248_RS11795 WP_000205166.1 501558..502145(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900701590]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497