Detailed information
Bioinformatically predicted
Overview
| Name | clpP | Type | Regulator |
| Locus tag | G8B37_RS07785 | Genome accession | NZ_CP049695 |
| Coordinates | 1543645..1544235 (-) | Length | 196 a.a. |
| NCBI ID | WP_002985850.1 | Uniprot ID | A0A9X8T4H8 |
| Organism | Streptococcus pyogenes strain ABC76 | ||
| Function | degradation of ComX (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1481763..1565327 | 1543645..1544235 | within | 0 |
Gene organization within MGE regions
Location: 1481763..1565327
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G8B37_RS07470 (G8B37_07520) | - | 1482856..1483173 (-) | 318 | WP_021299375.1 | hypothetical protein | - |
| G8B37_RS07475 (G8B37_07525) | - | 1483222..1483449 (-) | 228 | WP_042769846.1 | Blp family class II bacteriocin | - |
| G8B37_RS09560 | - | 1483847..1483975 (-) | 129 | WP_002994583.1 | hypothetical protein | - |
| G8B37_RS09685 (G8B37_07530) | - | 1484060..1484344 (-) | 285 | WP_079891230.1 | CPBP family intramembrane glutamic endopeptidase | - |
| G8B37_RS07485 (G8B37_07535) | - | 1484665..1484841 (-) | 177 | WP_002994581.1 | hypothetical protein | - |
| G8B37_RS07490 (G8B37_07540) | - | 1484819..1485043 (-) | 225 | WP_002994580.1 | Blp family class II bacteriocin | - |
| G8B37_RS09565 | - | 1485341..1486947 (+) | 1607 | Protein_1432 | ABC transporter transmembrane domain-containing protein | - |
| G8B37_RS09570 | - | 1487144..1487362 (-) | 219 | WP_011528334.1 | LytTR family transcriptional regulator DNA-binding domain-containing protein | - |
| G8B37_RS09575 (G8B37_07565) | - | 1487663..1487917 (+) | 255 | WP_010921971.1 | hypothetical protein | - |
| G8B37_RS07515 (G8B37_07570) | - | 1488222..1488698 (-) | 477 | WP_014635332.1 | NUDIX hydrolase | - |
| G8B37_RS07520 (G8B37_07575) | era | 1488718..1489614 (-) | 897 | WP_003047080.1 | GTPase Era | - |
| G8B37_RS07525 (G8B37_07580) | - | 1489734..1490141 (-) | 408 | WP_002985746.1 | diacylglycerol kinase family protein | - |
| G8B37_RS07530 (G8B37_07585) | ybeY | 1490122..1490619 (-) | 498 | WP_002985748.1 | rRNA maturation RNase YbeY | - |
| G8B37_RS07535 (G8B37_07590) | - | 1490778..1491353 (-) | 576 | WP_009880369.1 | uracil-DNA glycosylase family protein | - |
| G8B37_RS07540 (G8B37_07595) | - | 1491399..1492451 (-) | 1053 | WP_010921967.1 | PhoH family protein | - |
| G8B37_RS07545 (G8B37_07600) | - | 1492610..1494382 (-) | 1773 | WP_042769843.1 | oleate hydratase | - |
| G8B37_RS07550 (G8B37_07605) | - | 1494698..1495879 (-) | 1182 | WP_011528331.1 | LysM domain-containing protein | - |
| G8B37_RS07555 (G8B37_07610) | - | 1496035..1496250 (-) | 216 | WP_002985757.1 | YozE family protein | - |
| G8B37_RS07560 (G8B37_07615) | msrA | 1496247..1496756 (-) | 510 | WP_002985759.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| G8B37_RS07565 (G8B37_07620) | - | 1496829..1497686 (-) | 858 | WP_011528329.1 | S1 RNA-binding domain-containing protein | - |
| G8B37_RS07570 (G8B37_07625) | frr | 1497795..1498352 (-) | 558 | WP_002985763.1 | ribosome recycling factor | - |
| G8B37_RS07575 (G8B37_07630) | pyrH | 1498381..1499109 (-) | 729 | WP_002985765.1 | UMP kinase | - |
| G8B37_RS07580 (G8B37_07635) | rplA | 1499431..1500120 (-) | 690 | WP_002985768.1 | 50S ribosomal protein L1 | - |
| G8B37_RS07585 (G8B37_07640) | rplK | 1500226..1500651 (-) | 426 | WP_002990800.1 | 50S ribosomal protein L11 | - |
| G8B37_RS07590 (G8B37_07645) | - | 1500895..1501248 (+) | 354 | WP_011528328.1 | DUF3397 domain-containing protein | - |
| G8B37_RS07595 (G8B37_07650) | - | 1501318..1503723 (-) | 2406 | WP_011528327.1 | DNA translocase FtsK | - |
| G8B37_RS07600 (G8B37_07655) | - | 1503940..1504746 (+) | 807 | WP_002990808.1 | peptidylprolyl isomerase | - |
| G8B37_RS07605 (G8B37_07660) | - | 1504894..1505748 (-) | 855 | WP_011017448.1 | metal ABC transporter permease | - |
| G8B37_RS07610 (G8B37_07665) | - | 1505749..1506474 (-) | 726 | WP_021299377.1 | metal ABC transporter ATP-binding protein | - |
| G8B37_RS07615 (G8B37_07670) | - | 1506538..1507470 (-) | 933 | WP_004218965.1 | metal ABC transporter substrate-binding protein | - |
| G8B37_RS07620 (G8B37_07675) | - | 1507616..1508263 (+) | 648 | WP_002985785.1 | metal-dependent transcriptional regulator | - |
| G8B37_RS07625 (G8B37_07680) | - | 1508360..1508701 (-) | 342 | WP_011528324.1 | hypothetical protein | - |
| G8B37_RS07630 (G8B37_07685) | - | 1508852..1509547 (-) | 696 | WP_011528323.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
| G8B37_RS07635 (G8B37_07690) | macP | 1509567..1509818 (-) | 252 | WP_002990826.1 | cell wall synthase accessory phosphoprotein MacP | - |
| G8B37_RS07640 (G8B37_07695) | - | 1509818..1510372 (-) | 555 | WP_002990829.1 | NUDIX hydrolase | - |
| G8B37_RS07645 (G8B37_07700) | glmU | 1510403..1511785 (-) | 1383 | WP_021299380.1 | bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU | - |
| G8B37_RS07650 (G8B37_07705) | - | 1511958..1513295 (-) | 1338 | WP_063815415.1 | MFS transporter | - |
| G8B37_RS07655 (G8B37_07710) | - | 1513628..1514587 (-) | 960 | WP_044555074.1 | Gfo/Idh/MocA family protein | - |
| G8B37_RS07660 (G8B37_07715) | - | 1514663..1515361 (-) | 699 | WP_011528320.1 | 3-oxoacyl-ACP reductase | - |
| G8B37_RS07665 (G8B37_07720) | - | 1515354..1515590 (-) | 237 | WP_002990844.1 | DUF2829 domain-containing protein | - |
| G8B37_RS07670 (G8B37_07730) | - | 1516290..1517257 (+) | 968 | Protein_1466 | DUF3644 domain-containing protein | - |
| G8B37_RS07675 (G8B37_07735) | - | 1517771..1518478 (+) | 708 | WP_011528316.1 | hypothetical protein | - |
| G8B37_RS07680 (G8B37_07740) | - | 1518572..1518823 (-) | 252 | WP_011017435.1 | hypothetical protein | - |
| G8B37_RS07685 (G8B37_07745) | - | 1519056..1519496 (-) | 441 | WP_042769849.1 | hypothetical protein | - |
| G8B37_RS07690 (G8B37_07750) | - | 1519955..1520707 (+) | 753 | WP_021299376.1 | ADP-ribosyltransferase | - |
| G8B37_RS07695 (G8B37_07755) | nrdE | 1520913..1523093 (-) | 2181 | WP_011528311.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| G8B37_RS07700 (G8B37_07760) | nrdI | 1523113..1523547 (-) | 435 | WP_011528310.1 | class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI | - |
| G8B37_RS07705 (G8B37_07765) | nrdF | 1523551..1524564 (-) | 1014 | WP_011528309.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| G8B37_RS07710 (G8B37_07770) | metG | 1525059..1527059 (-) | 2001 | WP_011528307.1 | methionine--tRNA ligase | - |
| G8B37_RS07715 (G8B37_07775) | - | 1527339..1528403 (-) | 1065 | Protein_1475 | ISAs1 family transposase | - |
| G8B37_RS07720 (G8B37_07780) | - | 1528555..1529262 (-) | 708 | WP_011528304.1 | YoaK family protein | - |
| G8B37_RS07725 (G8B37_07785) | scpC | 1530034..1534977 (-) | 4944 | WP_060388498.1 | CXC chemokine-degrading serine protease SpyCEP | - |
| G8B37_RS07730 (G8B37_07790) | - | 1535243..1536359 (-) | 1117 | Protein_1478 | alpha-hydroxy-acid oxidizing protein | - |
| G8B37_RS07735 (G8B37_07795) | - | 1536593..1537420 (+) | 828 | WP_021299194.1 | exodeoxyribonuclease III | - |
| G8B37_RS07740 (G8B37_07800) | - | 1537494..1537850 (-) | 357 | WP_002995120.1 | arsenate reductase family protein | - |
| G8B37_RS07745 (G8B37_07805) | - | 1538150..1538779 (+) | 630 | WP_011528296.1 | copper homeostasis protein CutC | - |
| G8B37_RS07750 (G8B37_07810) | - | 1538826..1539218 (-) | 393 | WP_002985833.1 | DUF5684 domain-containing protein | - |
| G8B37_RS07755 (G8B37_07815) | rsmI | 1539245..1540108 (-) | 864 | WP_002990904.1 | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | - |
| G8B37_RS07760 (G8B37_07820) | yabA | 1540113..1540436 (-) | 324 | WP_002985838.1 | DNA replication initiation control protein YabA | - |
| G8B37_RS07765 | - | 1540840..1541079 (-) | 240 | WP_021299187.1 | PSP1 C-terminal domain-containing protein | - |
| G8B37_RS07770 (G8B37_07830) | - | 1541098..1541973 (-) | 876 | WP_011528291.1 | DNA polymerase III subunit delta' | - |
| G8B37_RS07775 (G8B37_07835) | tmk | 1541991..1542626 (-) | 636 | WP_021299190.1 | dTMP kinase | - |
| G8B37_RS07780 (G8B37_07840) | - | 1542857..1543150 (-) | 294 | WP_002990928.1 | YlbG family protein | - |
| G8B37_RS07785 (G8B37_07845) | clpP | 1543645..1544235 (-) | 591 | WP_002985850.1 | ATP-dependent Clp protease proteolytic subunit | Regulator |
| G8B37_RS07790 (G8B37_07850) | upp | 1544459..1545088 (-) | 630 | WP_002985854.1 | uracil phosphoribosyltransferase | - |
| G8B37_RS07795 (G8B37_07855) | - | 1545256..1546890 (-) | 1635 | WP_011528289.1 | polysaccharide biosynthesis protein | - |
| G8B37_RS07800 (G8B37_07860) | - | 1546978..1548423 (+) | 1446 | WP_021299191.1 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase | - |
| G8B37_RS07805 (G8B37_07865) | - | 1548625..1550073 (+) | 1449 | Protein_1493 | IS1182 family transposase | - |
| G8B37_RS07810 (G8B37_07870) | - | 1550209..1550991 (+) | 783 | WP_011528285.1 | ABC transporter ATP-binding protein | - |
| G8B37_RS07815 (G8B37_07875) | - | 1551017..1551949 (+) | 933 | WP_011528284.1 | iron-hydroxamate ABC transporter substrate-binding protein | - |
| G8B37_RS07820 (G8B37_07880) | - | 1551939..1552991 (+) | 1053 | WP_011054214.1 | iron ABC transporter permease | - |
| G8B37_RS07825 (G8B37_07885) | - | 1552988..1553989 (+) | 1002 | WP_042769807.1 | iron ABC transporter permease | - |
| G8B37_RS07830 (G8B37_07890) | - | 1554034..1554687 (-) | 654 | WP_011528282.1 | DUF1803 domain-containing protein | - |
| G8B37_RS07835 (G8B37_07895) | - | 1554763..1555698 (-) | 936 | WP_002990948.1 | manganese-dependent inorganic pyrophosphatase | - |
| G8B37_RS07840 (G8B37_07900) | pflA | 1555829..1556620 (-) | 792 | WP_042769810.1 | pyruvate formate-lyase-activating protein | - |
| G8B37_RS07845 (G8B37_07905) | - | 1556698..1558032 (-) | 1335 | WP_002990953.1 | hemolysin family protein | - |
| G8B37_RS07850 (G8B37_07910) | - | 1558165..1558719 (-) | 555 | WP_002990955.1 | class I SAM-dependent methyltransferase | - |
| G8B37_RS07855 (G8B37_07915) | - | 1558758..1559678 (-) | 921 | WP_011017414.1 | TIGR01212 family radical SAM protein | - |
| G8B37_RS07860 (G8B37_07920) | - | 1559971..1560624 (-) | 654 | WP_011017413.1 | phosphatase PAP2 family protein | - |
| G8B37_RS07865 (G8B37_07925) | - | 1560626..1561189 (-) | 564 | WP_002990963.1 | ECF transporter S component | - |
| G8B37_RS07870 (G8B37_07930) | - | 1561500..1562048 (-) | 549 | WP_002990965.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
| G8B37_RS07875 (G8B37_07935) | yidD | 1562226..1562489 (-) | 264 | WP_002985889.1 | membrane protein insertion efficiency factor YidD | - |
| G8B37_RS07880 (G8B37_07940) | - | 1562486..1563208 (-) | 723 | WP_002990967.1 | pseudouridine synthase | - |
| G8B37_RS07885 (G8B37_07945) | scpB | 1563329..1563880 (-) | 552 | WP_002985894.1 | SMC-Scp complex subunit ScpB | - |
| G8B37_RS07890 (G8B37_07950) | - | 1563877..1564581 (-) | 705 | WP_002985896.1 | segregation/condensation protein A | - |
| G8B37_RS07895 (G8B37_07955) | xerD | 1564581..1565327 (-) | 747 | WP_002995825.1 | site-specific tyrosine recombinase XerD | - |
Sequence
Protein
Download Length: 196 a.a. Molecular weight: 21648.88 Da Isoelectric Point: 5.2834
>NTDB_id=427162 G8B37_RS07785 WP_002985850.1 1543645..1544235(-) (clpP) [Streptococcus pyogenes strain ABC76]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK
Nucleotide
Download Length: 591 bp
>NTDB_id=427162 G8B37_RS07785 WP_002985850.1 1543645..1544235(-) (clpP) [Streptococcus pyogenes strain ABC76]
ATGATTCCTGTTGTTATTGAACAAACTAGCCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACTAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCCGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCGCAAAATGCTGGAAAA
ACGATTAAACAAATCCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA
ATGATTCCTGTTGTTATTGAACAAACTAGCCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACTAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCCGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCGCAAAATGCTGGAAAA
ACGATTAAACAAATCCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| clpP | Streptococcus pyogenes MGAS315 |
100 |
100 |
1 |
| clpP | Streptococcus pyogenes JRS4 |
100 |
100 |
1 |
| clpP | Streptococcus mutans UA159 |
90.816 |
100 |
0.908 |
| clpP | Streptococcus pneumoniae Rx1 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus pneumoniae D39 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus pneumoniae R6 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus pneumoniae TIGR4 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus thermophilus LMG 18311 |
89.796 |
100 |
0.898 |
| clpP | Streptococcus thermophilus LMD-9 |
89.796 |
100 |
0.898 |
| clpP | Lactococcus lactis subsp. lactis strain DGCC12653 |
86.224 |
100 |
0.862 |
| clpP | Lactococcus lactis subsp. cremoris KW2 |
85.714 |
100 |
0.857 |
| clpP | Bacillus subtilis subsp. subtilis str. 168 |
57.143 |
100 |
0.571 |
| clpP | Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 |
56.995 |
98.469 |
0.561 |