Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   G8B45_RS04365 Genome accession   NZ_CP049687
Coordinates   836489..836677 (+) Length   62 a.a.
NCBI ID   WP_011528571.1    Uniprot ID   A0A660A3N3
Organism   Streptococcus pyogenes strain TSPY515     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 814699..843269 836489..836677 within 0


Gene organization within MGE regions


Location: 814699..843269
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  G8B45_RS04225 (G8B45_04260) - 814699..815292 (+) 594 WP_002990099.1 dTDP-4-dehydrorhamnose 3,5-epimerase family protein -
  G8B45_RS04230 (G8B45_04265) rfbB 815536..816576 (+) 1041 WP_002984881.1 dTDP-glucose 4,6-dehydratase -
  G8B45_RS04235 (G8B45_04270) - 816659..817594 (-) 936 WP_060388510.1 site-specific integrase -
  G8B45_RS04240 (G8B45_04275) - 817741..818061 (+) 321 WP_002995960.1 VRR-NUC domain-containing protein -
  G8B45_RS04245 (G8B45_04280) - 818045..818401 (+) 357 WP_011018138.1 hypothetical protein -
  G8B45_RS09440 - 818398..818649 (+) 252 WP_011528549.1 hypothetical protein -
  G8B45_RS04250 (G8B45_04285) - 818658..818867 (+) 210 Protein_795 DUF4355 domain-containing protein -
  G8B45_RS04255 (G8B45_04290) - 818886..819776 (+) 891 WP_011528556.1 hypothetical protein -
  G8B45_RS04260 (G8B45_04295) - 819788..820081 (+) 294 WP_011528557.1 HeH/LEM domain-containing protein -
  G8B45_RS04265 (G8B45_04300) - 820095..820439 (+) 345 WP_060388512.1 hypothetical protein -
  G8B45_RS04270 (G8B45_04305) - 820436..820747 (+) 312 WP_011528559.1 hypothetical protein -
  G8B45_RS04275 (G8B45_04310) - 820744..821139 (+) 396 WP_011528560.1 hypothetical protein -
  G8B45_RS04280 (G8B45_04315) - 821141..821551 (+) 411 WP_011528561.1 DUF5072 family protein -
  G8B45_RS04285 (G8B45_04320) - 821566..821820 (+) 255 WP_231494232.1 phage major tail protein, TP901-1 family -
  G8B45_RS04290 (G8B45_04325) - 821833..822123 (+) 291 WP_060388513.1 hypothetical protein -
  G8B45_RS04295 (G8B45_04330) - 822080..823657 (+) 1578 WP_231494234.1 phage tail protein -
  G8B45_RS04300 (G8B45_04335) - 823658..825142 (+) 1485 WP_011528566.1 distal tail protein Dit -
  G8B45_RS04305 (G8B45_04340) - 825143..828592 (+) 3450 WP_011528567.1 glucosaminidase domain-containing protein -
  G8B45_RS04310 (G8B45_04345) - 828597..830459 (+) 1863 WP_011528568.1 DUF859 family phage minor structural protein -
  G8B45_RS04315 (G8B45_04350) - 830470..830817 (+) 348 WP_009880247.1 DUF1366 domain-containing protein -
  G8B45_RS09350 - 830831..830953 (+) 123 WP_015055953.1 hypothetical protein -
  G8B45_RS04320 (G8B45_04355) - 830967..831290 (+) 324 WP_015055952.1 hypothetical protein -
  G8B45_RS04325 (G8B45_04360) - 831290..831622 (+) 333 WP_011054798.1 phage holin -
  G8B45_RS04330 (G8B45_04365) - 831624..832388 (+) 765 WP_011054797.1 CHAP domain-containing protein -
  G8B45_RS04335 (G8B45_04370) - 832400..833002 (+) 603 WP_011054796.1 hypothetical protein -
  G8B45_RS04340 (G8B45_04375) - 833013..833786 (+) 774 WP_011528569.1 hypothetical protein -
  G8B45_RS04345 (G8B45_04380) - 833796..834017 (+) 222 WP_009880241.1 hypothetical protein -
  G8B45_RS04350 (G8B45_04385) - 834017..834676 (+) 660 WP_011528570.1 hypothetical protein -
  G8B45_RS04355 (G8B45_04390) - 834745..835179 (-) 435 WP_011017966.1 hypothetical protein -
  G8B45_RS04360 (G8B45_04395) sda3 835451..836251 (-) 801 WP_011285611.1 streptodornase Sda3 -
  G8B45_RS04365 (G8B45_04400) prx 836489..836677 (+) 189 WP_011528571.1 hypothetical protein Regulator
  G8B45_RS04370 (G8B45_04405) - 837085..837561 (+) 477 WP_002984880.1 8-oxo-dGTP diphosphatase -
  G8B45_RS04375 (G8B45_04410) - 837619..838800 (+) 1182 WP_002984879.1 AI-2E family transporter -
  G8B45_RS04380 (G8B45_04415) - 838790..840037 (+) 1248 WP_002984878.1 tetratricopeptide repeat protein -
  G8B45_RS04385 (G8B45_04420) fbp54 840096..841748 (-) 1653 WP_021299312.1 Rqc2 family fibronectin-binding protein Fbp54 -
  G8B45_RS04390 (G8B45_04425) trpX 842102..843100 (+) 999 WP_011184452.1 tryptophan ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 62 a.a.        Molecular weight: 7224.11 Da        Isoelectric Point: 4.0606

>NTDB_id=426700 G8B45_RS04365 WP_011528571.1 836489..836677(+) (prx) [Streptococcus pyogenes strain TSPY515]
MLTYDEFKQAIDREYITGDTVMIVRKNGQIFDYVLPHEEVRNGEVVTIERISDVMAELSESE

Nucleotide


Download         Length: 189 bp        

>NTDB_id=426700 G8B45_RS04365 WP_011528571.1 836489..836677(+) (prx) [Streptococcus pyogenes strain TSPY515]
ATGCTAACATATGACGAGTTTAAGCAAGCAATCGACCGTGAATATATCACAGGAGACACAGTTATGATCGTGCGCAAGAA
CGGACAGATTTTTGATTATGTGTTGCCGCATGAAGAAGTGAGAAATGGGGAAGTTGTGACAATCGAGCGGATATCAGATG
TTATGGCAGAACTTTCTGAGTCTGAATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A3N3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

76.667

96.774

0.742
  prx Streptococcus pyogenes MGAS315

76.271

95.161

0.726
  prx Streptococcus pyogenes MGAS8232

76.271

95.161

0.726
  prx Streptococcus pyogenes MGAS315

71.667

96.774

0.694
  prx Streptococcus pyogenes MGAS315

90.698

69.355

0.629
  prx Streptococcus pyogenes MGAS315

85.366

66.129

0.565
  prx Streptococcus pyogenes MGAS315

76.19

67.742

0.516