Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   HMPREF0833_RS07230 Genome accession   NC_015678
Coordinates   1585346..1586527 (+) Length   393 a.a.
NCBI ID   WP_013904367.1    Uniprot ID   I1ZPR6
Organism   Streptococcus parasanguinis ATCC 15912     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1580346..1591527
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0833_RS07210 (HMPREF0833_11470) comE/comE2 1582103..1582861 (-) 759 WP_003018434.1 response regulator transcription factor Regulator
  HMPREF0833_RS07215 (HMPREF0833_11471) - 1582858..1584198 (-) 1341 WP_041818394.1 GHKL domain-containing protein -
  HMPREF0833_RS07225 (HMPREF0833_11472) rlmH 1584662..1585141 (-) 480 WP_003009233.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  HMPREF0833_RS07230 (HMPREF0833_11473) htrA 1585346..1586527 (+) 1182 WP_013904367.1 S1C family serine protease Regulator
  HMPREF0833_RS07235 (HMPREF0833_11474) spo0J 1586599..1587360 (+) 762 WP_013904368.1 ParB/RepB/Spo0J family partition protein Regulator
  HMPREF0833_RS07240 (HMPREF0833_11475) dnaA 1587627..1588985 (+) 1359 WP_003018430.1 chromosomal replication initiator protein DnaA -
  HMPREF0833_RS07245 (HMPREF0833_11476) dnaN 1589144..1590280 (+) 1137 WP_013904369.1 DNA polymerase III subunit beta -
  HMPREF0833_RS07250 (HMPREF0833_11477) - 1590293..1590484 (+) 192 WP_003018426.1 DUF951 domain-containing protein -
  HMPREF0833_RS07255 (HMPREF0833_11478) - 1590520..1591017 (-) 498 WP_003018398.1 DUF1307 domain-containing protein -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41690.83 Da        Isoelectric Point: 6.1559

>NTDB_id=41393 HMPREF0833_RS07230 WP_013904367.1 1585346..1586527(+) (htrA) [Streptococcus parasanguinis ATCC 15912]
MKSSSNLLKKVGNIALIFVVGFLGGILGTFLTLKTSHSSTSNTESKQVHSTTVKTAYKNTTSTSEAVDKVKNAVVSVITY
SDSSNQGVFEKEENPDSQISSEGSGVIYKKEGKYAYLVTNTHVINGAKKVDILLADGNKVSGEVVGSDVYSDIAVVRISA
DKAKAVAEFGDSNQLTVGETAIAIGSPLGTDYANSVTQGIISSQGRNVKLKADNGQNISTRALQTDAAINPGNSGGPLIN
IQGQVIGITSSKISNNGQTSVEGMGFAIPANDVVNIIKQLEEKGKVVRPALGIQMMDLSNLSTSDLSQLKLPEKISGGVL
VRSTLENMPASDKLQRYDVITKIDDTDIESTADLQSALYSHQINDTIKVTFYRDGKQQTTSIKLTKSTEDLSE

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=41393 HMPREF0833_RS07230 WP_013904367.1 1585346..1586527(+) (htrA) [Streptococcus parasanguinis ATCC 15912]
ATGAAATCTTCATCTAATTTACTGAAAAAAGTTGGGAACATAGCCCTCATTTTTGTTGTAGGTTTTCTAGGTGGGATTCT
TGGAACCTTTTTAACCTTAAAAACATCTCATTCTTCTACTTCAAATACTGAAAGTAAGCAAGTCCACTCAACCACTGTTA
AAACAGCTTATAAAAACACAACCTCAACTAGTGAGGCCGTCGATAAGGTGAAAAATGCTGTAGTTTCTGTGATTACTTAT
TCTGATTCTTCGAATCAAGGAGTGTTTGAAAAAGAAGAAAACCCTGACTCACAAATTTCTAGTGAAGGTTCTGGGGTCAT
TTATAAAAAAGAAGGAAAATATGCCTACCTTGTTACCAATACCCATGTGATCAATGGTGCTAAAAAAGTAGATATTCTTT
TAGCAGATGGTAATAAAGTCTCTGGAGAAGTAGTTGGGTCAGATGTCTATTCTGATATTGCAGTAGTTCGAATTAGTGCG
GATAAAGCAAAGGCAGTAGCTGAATTCGGAGATTCAAACCAATTAACGGTCGGTGAGACTGCAATTGCAATTGGCAGCCC
TCTTGGAACAGATTATGCTAATTCTGTTACCCAAGGGATTATTTCCAGCCAAGGTCGCAATGTGAAATTGAAAGCCGATA
ATGGACAAAATATCTCTACACGCGCTCTACAAACAGACGCAGCCATCAACCCAGGAAACTCTGGAGGTCCATTAATCAAT
ATTCAAGGACAAGTCATCGGGATTACCTCAAGTAAAATTTCAAATAACGGACAAACTTCAGTAGAAGGAATGGGATTTGC
AATTCCTGCAAATGATGTTGTCAATATTATCAAGCAACTAGAAGAAAAAGGAAAAGTAGTTCGACCAGCTCTTGGAATCC
AAATGATGGATTTATCCAACCTTTCAACTTCTGATTTAAGCCAATTAAAACTACCTGAAAAAATCTCTGGAGGAGTACTG
GTTCGTTCAACACTTGAAAATATGCCTGCTTCAGATAAATTGCAACGCTACGATGTGATCACAAAGATCGACGATACAGA
TATCGAGTCAACTGCAGATTTACAATCTGCCCTCTATTCTCACCAAATCAATGATACGATCAAGGTCACATTCTATCGTG
ATGGAAAACAACAAACAACTTCTATCAAGTTAACAAAATCAACTGAGGATCTTAGTGAGTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(289-384)

Trypsin-like peptidase domain (Trypsin_2)

(103-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I1ZPR6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

67.839

100

0.687
  htrA Streptococcus mitis NCTC 12261

62.972

100

0.636
  htrA Streptococcus pneumoniae Rx1

63.104

100

0.631
  htrA Streptococcus pneumoniae D39

63.104

100

0.631
  htrA Streptococcus pneumoniae R6

63.104

100

0.631
  htrA Streptococcus pneumoniae TIGR4

63.104

100

0.631
  htrA Streptococcus mutans UA159

53.747

98.473

0.529

Multiple sequence alignment