Detailed information NTG0041372

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: HMPREF0833_RS01445
• Genome accession: NC_015678
• Coordinates: 291415..292095 (+)
• Length: 226 a.a.
• NCBI ID: WP_037607818.1
• Uniprot ID: A0A2I1TVC1
• Organism: Streptococcus parasanguinis ATCC 15912
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 286415..297095

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF0833_RS01420 (HMPREF0833_10275)	-	287371..288081 (-)	711	WP_013903371.1	LytTR family DNA-binding domain-containing protein	-
HMPREF0833_RS01425 (HMPREF0833_10276)	-	288188..289144 (+)	957	WP_013903372.1	ABC transporter ATP-binding protein	-
HMPREF0833_RS01430 (HMPREF0833_10277)	-	289146..289868 (+)	723	WP_013903373.1	ABC transporter permease	-
HMPREF0833_RS01435 (HMPREF0833_10278)	-	290021..290554 (-)	534	WP_003017471.1	biotin transporter BioY	-
HMPREF0833_RS01440 (HMPREF0833_10279)	-	290761..291279 (+)	519	WP_013903375.1	hypothetical protein	-
HMPREF0833_RS01445 (HMPREF0833_10280)	ciaR	291415..292095 (+)	681	WP_037607818.1	response regulator transcription factor	Regulator
HMPREF0833_RS01450 (HMPREF0833_10281)	ciaH	292079..293449 (+)	1371	WP_013903377.1	cell wall metabolism sensor histidine kinase WalK	Regulator
HMPREF0833_RS01455 (HMPREF0833_10282)	-	293465..293845 (+)	381	WP_003003384.1	VOC family protein	-
HMPREF0833_RS01460 (HMPREF0833_10283)	-	293956..295338 (+)	1383	WP_013903378.1	polysaccharide deacetylase family protein	-
HMPREF0833_RS01465 (HMPREF0833_10284)	-	295381..296466 (-)	1086	WP_013903379.1	DEAD/DEAH box helicase	-

Sequence

Protein

• Length: 226 a.a.
• Molecular weight: 25709.43 Da
• Isoelectric Point: 4.3559

>NTDB_id=41372 HMPREF0833_RS01445 WP_037607818.1 291415..292095(+) (ciaR) [Streptococcus parasanguinis ATCC 15912]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGIYDLILLDLMLPEKDGFHVLKELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKVNENTLNYGNLKVNLSTNSTYVDGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVESLQTLRSVGYILKDANQN

Nucleotide

• Length: 681 bp

>NTDB_id=41372 HMPREF0833_RS01445 WP_037607818.1 291415..292095(+) (ciaR) [Streptococcus parasanguinis ATCC 15912]
ATGATTAAAATTCTATTGGTCGAAGATGACCTTGGTTTGTCAAATTCAGTATTTGATTTTTTAGATGATTTTGCGGACGT
CATGCAGGTCTTTGACGGAGAAGAAGGTCTTTACGAAGCAGAAAGCGGGATCTATGATTTGATTTTGCTGGACCTCATGC
TTCCTGAAAAAGACGGCTTCCATGTCTTGAAAGAATTGCGTGAAAAAGGCGTGACAACCCCTGTTTTGATCATGACAGCT
AAAGAAAGTCTGGATGACAAAGGACACGGATTTGAGCTGGGGGCAGACGATTACCTCACCAAACCTTTCTACCTAGAAGA
GCTTAAGATGCGGATTCAAGCCCTCTTGAAGCGCTCAGGAAAAGTGAATGAAAACACCCTTAATTATGGCAATTTGAAGG
TTAACTTATCTACCAATTCGACTTACGTGGACGGTAAGGAAGTGGAACTTCTTGGGAAGGAATTTGATCTCTTGGTCTAT
TTCCTTCAAAACCAAAATGTCATCCTTCCAAAAACACAGATTTTCGATCGCCTTTGGGGCTTTGACAGTGATACGACCAT
CTCTGTTGTTGAGGTCTATGTTTCAAAAATCCGTAAGAAATTAAAAGGTACTGATTTCGTTGAGAGCTTGCAAACATTGC
GCAGTGTGGGGTATATCTTAAAAGATGCTAACCAGAATTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A2I1TVC1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.179	99.115	0.894
ciaR	Streptococcus pneumoniae D39	90.179	99.115	0.894
ciaR	Streptococcus pneumoniae R6	90.179	99.115	0.894
ciaR	Streptococcus pneumoniae TIGR4	90.179	99.115	0.894
ciaR	Streptococcus mutans UA159	88.393	99.115	0.876
vicR	Streptococcus mutans UA159	36.481	100	0.376
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.889	99.558	0.367
covR	Streptococcus salivarius strain HSISS4	36.123	100	0.363