Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   HMPREF0833_RS01450 Genome accession   NC_015678
Coordinates   292079..293449 (+) Length   456 a.a.
NCBI ID   WP_013903377.1    Uniprot ID   I1ZL93
Organism   Streptococcus parasanguinis ATCC 15912     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 287079..298449
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0833_RS01420 (HMPREF0833_10275) - 287371..288081 (-) 711 WP_013903371.1 LytTR family DNA-binding domain-containing protein -
  HMPREF0833_RS01425 (HMPREF0833_10276) - 288188..289144 (+) 957 WP_013903372.1 ABC transporter ATP-binding protein -
  HMPREF0833_RS01430 (HMPREF0833_10277) - 289146..289868 (+) 723 WP_013903373.1 ABC transporter permease -
  HMPREF0833_RS01435 (HMPREF0833_10278) - 290021..290554 (-) 534 WP_003017471.1 biotin transporter BioY -
  HMPREF0833_RS01440 (HMPREF0833_10279) - 290761..291279 (+) 519 WP_013903375.1 hypothetical protein -
  HMPREF0833_RS01445 (HMPREF0833_10280) ciaR 291415..292095 (+) 681 WP_037607818.1 response regulator transcription factor Regulator
  HMPREF0833_RS01450 (HMPREF0833_10281) ciaH 292079..293449 (+) 1371 WP_013903377.1 cell wall metabolism sensor histidine kinase WalK Regulator
  HMPREF0833_RS01455 (HMPREF0833_10282) - 293465..293845 (+) 381 WP_003003384.1 VOC family protein -
  HMPREF0833_RS01460 (HMPREF0833_10283) - 293956..295338 (+) 1383 WP_013903378.1 polysaccharide deacetylase family protein -
  HMPREF0833_RS01465 (HMPREF0833_10284) - 295381..296466 (-) 1086 WP_013903379.1 DEAD/DEAH box helicase -
  HMPREF0833_RS01470 (HMPREF0833_10285) - 296463..297449 (-) 987 WP_013903380.1 Gfo/Idh/MocA family protein -

Sequence

Protein


Download         Length: 456 a.a.        Molecular weight: 52049.53 Da        Isoelectric Point: 6.8851

>NTDB_id=41373 HMPREF0833_RS01450 WP_013903377.1 292079..293449(+) (ciaH) [Streptococcus parasanguinis ATCC 15912]
MLTRIKKTVGEDDFSYFIRYFGLFTLIFSAMTLIIIQVMRSSLYTTVDENLKTLSKDPYSLAAIAYRDQRQSKDKDNDED
PEVMIPDHDKSEPKGDVTSNTTVVLLNRNYENLTTGNGFLNFKSVTFGRKLLNKVSQLQITNSYGKKESYRAYMTDLGLT
DDGGSDVKYAVIMTNISQLEQTSEEHESQIALVMICFWGISLFASLFLARLSVKPLLESMQKQKAFVENASHELRTPLAV
LQNRLETLFRKPEATIMESSESIASSLDEVRNMKLLTTNLLNIARRDDGLKPEIEEIEPSFFDQTFSNFEIIAEENGKFF
QGDNQVDKVICSDKTLLKQLMTILYDNALKYTDEDGEIQFEVQLKDKNLLLRALDNGPGVRDEDKKRIFDRFYRVDKART
RQKGGFGLGLSLAKQIVEAFKGTIQVKDNKPKGSIFEVKLSIKTESRKKIVHNLKK

Nucleotide


Download         Length: 1371 bp        

>NTDB_id=41373 HMPREF0833_RS01450 WP_013903377.1 292079..293449(+) (ciaH) [Streptococcus parasanguinis ATCC 15912]
ATGCTAACCAGAATTAAGAAAACTGTCGGAGAAGATGATTTTTCCTACTTCATCCGATATTTTGGGCTCTTTACCTTGAT
ATTTTCAGCAATGACCTTGATTATCATTCAGGTTATGCGCTCGAGTCTCTATACAACTGTCGATGAGAACCTCAAGACTT
TAAGTAAGGATCCTTATTCGCTAGCGGCTATTGCTTATCGGGACCAGCGACAATCGAAAGATAAGGATAATGATGAAGAT
CCTGAGGTGATGATCCCAGATCATGATAAATCAGAACCCAAAGGAGATGTCACATCCAATACCACTGTTGTATTGCTCAA
CAGAAATTATGAAAATCTGACGACAGGCAACGGATTTTTAAACTTTAAATCTGTCACTTTTGGCCGGAAGTTGCTCAACA
AAGTTTCCCAGCTCCAAATTACAAATAGCTACGGGAAAAAAGAAAGTTACCGTGCTTATATGACAGATTTGGGATTGACT
GATGATGGGGGAAGTGACGTCAAGTATGCGGTTATCATGACCAATATTAGTCAGTTGGAGCAGACGAGTGAAGAGCACGA
AAGCCAAATCGCTCTTGTCATGATCTGCTTCTGGGGAATTTCTTTGTTTGCTAGTCTTTTCCTAGCACGTCTCAGCGTTA
AACCCCTTCTTGAGAGTATGCAAAAGCAAAAGGCTTTCGTAGAAAATGCCTCCCATGAATTGCGGACGCCTTTAGCAGTC
CTGCAAAATCGCCTCGAAACGCTTTTTAGAAAGCCTGAGGCGACCATTATGGAATCGAGTGAGAGTATTGCATCCAGCTT
GGATGAAGTTCGAAATATGAAGCTCTTGACCACCAACCTTCTTAATATTGCCCGGAGGGATGATGGCTTGAAGCCAGAGA
TAGAAGAAATTGAGCCAAGCTTTTTCGATCAGACCTTCTCGAATTTTGAGATCATTGCGGAAGAAAATGGCAAATTCTTC
CAGGGGGACAATCAGGTGGACAAAGTCATTTGTTCTGATAAAACGCTCCTCAAGCAGTTGATGACCATTCTCTATGACAA
TGCCTTGAAGTACACCGACGAAGATGGTGAGATTCAGTTTGAAGTCCAGTTGAAGGACAAAAATCTTCTTTTGAGAGCAC
TGGATAATGGACCTGGTGTTCGAGACGAGGACAAGAAACGGATCTTTGATCGTTTTTACCGGGTGGATAAAGCCAGAACC
CGTCAAAAAGGTGGATTTGGTTTGGGACTATCTTTAGCCAAACAAATTGTAGAGGCTTTTAAGGGAACCATTCAAGTTAA
AGATAATAAACCAAAAGGTTCCATCTTTGAAGTAAAATTATCCATCAAGACGGAAAGTCGTAAAAAAATCGTTCATAATT
TAAAAAAATAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(224-289)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(333-441)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I1ZL93

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

59.333

98.684

0.586
  ciaH Streptococcus pneumoniae D39

59.333

98.684

0.586
  ciaH Streptococcus pneumoniae R6

59.333

98.684

0.586
  ciaH Streptococcus pneumoniae TIGR4

59.333

98.684

0.586
  ciaH Streptococcus mutans UA159

50.227

96.491

0.485

Multiple sequence alignment