Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   GOM46_RS05405 Genome accession   NZ_CP046525
Coordinates   1075532..1076203 (-) Length   223 a.a.
NCBI ID   WP_006151225.1    Uniprot ID   F5W293
Organism   Streptococcus infantis strain SO     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1070532..1081203
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GOM46_RS05380 (GOM46_05370) - 1070743..1071672 (-) 930 WP_006151241.1 peptidase U32 family protein -
  GOM46_RS05385 (GOM46_05375) - 1071782..1072462 (-) 681 WP_006151245.1 ABC transporter ATP-binding protein -
  GOM46_RS05390 (GOM46_05380) - 1072476..1073531 (-) 1056 WP_006151269.1 ABC transporter permease -
  GOM46_RS05395 (GOM46_05385) - 1073903..1074178 (+) 276 WP_006151224.1 DUF3270 family protein -
  GOM46_RS05400 (GOM46_05390) ciaH 1074205..1075539 (-) 1335 WP_006151280.1 sensor histidine kinase Regulator
  GOM46_RS05405 (GOM46_05395) ciaR 1075532..1076203 (-) 672 WP_006151225.1 response regulator transcription factor Regulator
  GOM46_RS05410 (GOM46_05400) - 1076317..1078863 (-) 2547 WP_235083314.1 M1 family metallopeptidase -
  GOM46_RS05415 (GOM46_05405) - 1079159..1081156 (+) 1998 WP_006151232.1 LPXTG cell wall anchor domain-containing protein -

Sequence

Protein


Download         Length: 223 a.a.        Molecular weight: 25345.12 Da        Isoelectric Point: 4.4452

>NTDB_id=405076 GOM46_RS05405 WP_006151225.1 1075532..1076203(-) (ciaR) [Streptococcus infantis strain SO]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGISTPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDLTVNLSTNEVKVHDTSVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKHV

Nucleotide


Download         Length: 672 bp        

>NTDB_id=405076 GOM46_RS05405 WP_006151225.1 1075532..1076203(-) (ciaR) [Streptococcus infantis strain SO]
ATGATCAAAATTCTATTAGTGGAAGATGACCTAGGCCTGTCAAATTCAGTCTTTGATTTTTTGGATGATTTTGCTGATGT
TATGCAGGTTTTTGATGGAGAAGAAGGTCTTTATGAGGCTGAAAGTGGCGTATATGATTTGATTCTATTGGACTTGATGT
TGCCTGAAAAAAATGGATTCCAAGTTTTAAAAGAATTGCGTGAAAAAGGTATTTCGACTCCTGTTCTGATCATGACAGCA
AAGGAAAGTATCGATGACAAAGGACATGGATTTGAACTTGGAGCAGATGATTATCTGACAAAACCTTTCTATTTGGAAGA
GCTCAAGATGCGTATCCAAGCCCTTCTCAAACGTTCTGGGAAATTCAACGAAAATACTCTTTCTTATGGAGATTTGACGG
TTAACCTCTCTACAAATGAGGTTAAGGTTCACGATACTTCTGTTGAGTTGCTCGGTAAAGAATTTGAACTCTTGGTCTAT
TTCCTCCAAAACCAAAATGTTATCCTACCTAAGACACAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACGACTAT
TTCAGTAGTAGAAGTTTATGTATCAAAAGTTCGTAAGAAATTAAAGGGGACAGCCTTTGCTGAAAATCTCCAAACCTTGC
GTAGTGTTGGGTATATTTTAAAACATGTTTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F5W293

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

94.17

100

0.942
  ciaR Streptococcus pneumoniae D39

94.17

100

0.942
  ciaR Streptococcus pneumoniae R6

94.17

100

0.942
  ciaR Streptococcus pneumoniae TIGR4

94.17

100

0.942
  ciaR Streptococcus mutans UA159

87.783

99.103

0.87
  vicR Streptococcus mutans UA159

36.91

100

0.386
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.889

100

0.372
  micA Streptococcus pneumoniae Cp1015

34.764

100

0.363

Multiple sequence alignment