Detailed information
Bioinformatically predicted
Overview
| Name | clpP | Type | Regulator |
| Locus tag | GL186_RS03315 | Genome accession | NZ_CP046358 |
| Coordinates | 658720..659310 (+) | Length | 196 a.a. |
| NCBI ID | WP_000613477.1 | Uniprot ID | A0A064BX72 |
| Organism | Streptococcus pneumoniae strain 566 | ||
| Function | degradation of ComX; degradation of ComW (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 629424..694991 | 658720..659310 | within | 0 |
Gene organization within MGE regions
Location: 629424..694991
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GL186_RS03160 (GL186_03255) | - | 629850..629984 (+) | 135 | Protein_637 | lactate oxidase | - |
| GL186_RS03165 (GL186_03260) | lysS | 630124..631614 (+) | 1491 | WP_000102469.1 | lysine--tRNA ligase | - |
| GL186_RS03170 (GL186_03265) | lctO | 632240..633376 (+) | 1137 | WP_000120707.1 | L-lactate oxidase | - |
| GL186_RS03175 (GL186_03270) | - | 633933..634601 (+) | 669 | WP_000449815.1 | TenA family protein | - |
| GL186_RS11335 (GL186_03275) | - | 634656..634787 (-) | 132 | WP_050227179.1 | hypothetical protein | - |
| GL186_RS03180 (GL186_03280) | thiM | 634890..635672 (+) | 783 | WP_000202473.1 | hydroxyethylthiazole kinase | - |
| GL186_RS03185 (GL186_03285) | thiE | 635674..636303 (+) | 630 | WP_000468576.1 | thiamine phosphate synthase | - |
| GL186_RS03190 (GL186_03290) | - | 636862..637422 (+) | 561 | WP_000915286.1 | ECF transporter S component | - |
| GL186_RS03195 (GL186_03295) | - | 637423..638808 (+) | 1386 | WP_024477898.1 | ATP-binding cassette domain-containing protein | - |
| GL186_RS03200 (GL186_03300) | - | 638810..639460 (+) | 651 | WP_000241371.1 | energy-coupling factor transporter transmembrane component T | - |
| GL186_RS03205 (GL186_03305) | tenA | 639471..640163 (+) | 693 | WP_000397211.1 | thiaminase II | - |
| GL186_RS03210 (GL186_03310) | thiW | 640168..640692 (+) | 525 | WP_001225557.1 | energy coupling factor transporter S component ThiW | - |
| GL186_RS03215 (GL186_03315) | - | 640692..641495 (+) | 804 | WP_001155186.1 | hydroxyethylthiazole kinase | - |
| GL186_RS03220 (GL186_03320) | thiE | 641488..642120 (+) | 633 | WP_001078231.1 | thiamine phosphate synthase | - |
| GL186_RS03225 (GL186_03325) | thiD | 642330..643121 (-) | 792 | WP_061714004.1 | bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase | - |
| GL186_RS03230 (GL186_03330) | - | 643487..643882 (+) | 396 | WP_001167216.1 | CopY/TcrY family copper transport repressor | - |
| GL186_RS03235 (GL186_03335) | - | 643893..644264 (+) | 372 | WP_000935065.1 | cupredoxin domain-containing protein | - |
| GL186_RS03240 (GL186_03340) | - | 644274..646517 (+) | 2244 | WP_000136282.1 | heavy metal translocating P-type ATPase | - |
| GL186_RS03245 (GL186_03345) | spxB | 646724..648499 (+) | 1776 | WP_000191798.1 | pyruvate oxidase | - |
| GL186_RS03250 (GL186_03350) | - | 648610..648957 (+) | 348 | WP_001052655.1 | VOC family protein | - |
| GL186_RS03255 (GL186_03355) | - | 649074..649985 (-) | 912 | Protein_657 | IS630 family transposase | - |
| GL186_RS03260 (GL186_03360) | - | 650371..650676 (+) | 306 | Protein_658 | family 1 glycosylhydrolase | - |
| GL186_RS03265 (GL186_03365) | manA | 650808..651752 (+) | 945 | WP_001294318.1 | mannose-6-phosphate isomerase, class I | - |
| GL186_RS03270 (GL186_03370) | - | 651774..653249 (-) | 1476 | WP_001813257.1 | sodium-dependent transporter | - |
| GL186_RS03280 (GL186_03380) | - | 653332..654086 (+) | 755 | Protein_661 | MerR family transcriptional regulator | - |
| GL186_RS03285 (GL186_03385) | - | 654106..654561 (-) | 456 | WP_001823744.1 | 8-oxo-dGTP diphosphatase | - |
| GL186_RS03290 (GL186_03390) | - | 654581..655756 (-) | 1176 | WP_197097173.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| GL186_RS03295 (GL186_03395) | - | 655815..656660 (-) | 846 | WP_000219939.1 | DegV family protein | - |
| GL186_RS03300 (GL186_03400) | - | 656785..657342 (+) | 558 | WP_000004139.1 | TetR/AcrR family transcriptional regulator | - |
| GL186_RS03305 (GL186_03405) | - | 657361..657828 (+) | 468 | WP_000136976.1 | deoxycytidylate deaminase | - |
| GL186_RS03310 (GL186_03410) | upp | 657917..658546 (+) | 630 | WP_001812010.1 | uracil phosphoribosyltransferase | - |
| GL186_RS03315 (GL186_03415) | clpP | 658720..659310 (+) | 591 | WP_000613477.1 | ATP-dependent Clp protease proteolytic subunit ClpP | Regulator |
| GL186_RS03320 (GL186_03420) | - | 659389..659637 (+) | 249 | WP_000462126.1 | YlbG family protein | - |
| GL186_RS03325 (GL186_03425) | - | 659738..660898 (+) | 1161 | WP_000726146.1 | ABC transporter substrate-binding protein | - |
| GL186_RS03330 (GL186_03430) | - | 661166..662035 (+) | 870 | WP_000941421.1 | branched-chain amino acid ABC transporter permease | - |
| GL186_RS03335 (GL186_03435) | - | 662039..662995 (+) | 957 | WP_000662292.1 | branched-chain amino acid ABC transporter permease | - |
| GL186_RS03340 (GL186_03440) | - | 662995..663759 (+) | 765 | WP_001186003.1 | ABC transporter ATP-binding protein | - |
| GL186_RS03345 (GL186_03445) | - | 663759..664469 (+) | 711 | WP_000062219.1 | ABC transporter ATP-binding protein | - |
| GL186_RS03350 (GL186_03450) | - | 664883..665539 (+) | 657 | WP_000268677.1 | CBS domain-containing protein | - |
| GL186_RS03355 (GL186_03455) | prfB | 665647..666742 (+) | 1096 | WP_015511312.1 | peptide chain release factor 2 | - |
| GL186_RS03360 (GL186_03460) | ftsE | 666760..667452 (+) | 693 | WP_000022264.1 | cell division ATP-binding protein FtsE | - |
| GL186_RS03365 (GL186_03465) | ftsX | 667445..668371 (+) | 927 | WP_024477896.1 | permease-like cell division protein FtsX | - |
| GL186_RS03370 (GL186_03470) | - | 668553..669506 (-) | 954 | WP_001155339.1 | IS30-like element ISSpn8 family transposase | - |
| GL186_RS03375 (GL186_03475) | - | 669903..672083 (+) | 2181 | WP_000974062.1 | PTS transporter subunit IIBC | - |
| GL186_RS03380 (GL186_03480) | - | 672135..672950 (+) | 816 | WP_000670830.1 | endonuclease/exonuclease/phosphatase family protein | - |
| GL186_RS03385 (GL186_03485) | - | 673090..674433 (+) | 1344 | WP_000011015.1 | DEAD/DEAH box helicase | - |
| GL186_RS03390 (GL186_03490) | metK | 674648..675838 (+) | 1191 | WP_000003936.1 | methionine adenosyltransferase | - |
| GL186_RS03395 (GL186_03495) | - | 676391..677326 (+) | 936 | WP_024477895.1 | dihydroorotate oxidase | - |
| GL186_RS03400 (GL186_03500) | holA | 677360..678397 (+) | 1038 | WP_000879650.1 | DNA polymerase III subunit delta | - |
| GL186_RS03405 (GL186_03505) | sodA | 678538..679143 (+) | 606 | WP_000974746.1 | superoxide dismutase SodA | - |
| GL186_RS03410 (GL186_03510) | - | 679301..679831 (+) | 531 | WP_001224351.1 | YutD family protein | - |
| GL186_RS03415 (GL186_03515) | rlmN | 679852..680754 (+) | 903 | WP_000804656.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| GL186_RS03420 (GL186_03520) | - | 680754..681236 (+) | 483 | WP_000976708.1 | VanZ family protein | - |
| GL186_RS03425 (GL186_03525) | - | 681238..682779 (+) | 1542 | WP_000025400.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| GL186_RS03430 (GL186_03530) | - | 682834..684090 (-) | 1257 | WP_050229463.1 | ISL3 family transposase | - |
| GL186_RS03435 (GL186_03540) | - | 684257..685060 (-) | 804 | WP_000731918.1 | peptidylprolyl isomerase | - |
| GL186_RS03440 (GL186_03545) | - | 685144..685365 (-) | 222 | WP_000011699.1 | hypothetical protein | - |
| GL186_RS03445 (GL186_03550) | - | 685844..686053 (-) | 210 | WP_000953865.1 | hypothetical protein | - |
| GL186_RS03450 (GL186_03555) | rpsP | 686223..686495 (+) | 273 | WP_000268761.1 | 30S ribosomal protein S16 | - |
| GL186_RS03455 (GL186_03560) | kphA | 686515..686754 (+) | 240 | WP_000379621.1 | RNA-binding protein KphA | - |
| GL186_RS11055 (GL186_03565) | - | 686915..687226 (+) | 312 | Protein_697 | MazG nucleotide pyrophosphohydrolase domain-containing protein | - |
| GL186_RS03465 (GL186_03570) | - | 687330..688079 (+) | 750 | WP_000819199.1 | alpha/beta hydrolase | - |
| GL186_RS03470 (GL186_03575) | rimM | 688149..688667 (+) | 519 | WP_001105899.1 | ribosome maturation factor RimM | - |
| GL186_RS03475 (GL186_03580) | trmD | 688657..689376 (+) | 720 | WP_000686921.1 | tRNA (guanosine(37)-N1)-methyltransferase TrmD | - |
| GL186_RS03480 (GL186_03585) | - | 689388..689726 (+) | 339 | WP_001196049.1 | ATP cone domain-containing protein | - |
| GL186_RS03485 (GL186_03590) | - | 689757..690077 (-) | 321 | WP_001216099.1 | hypothetical protein | - |
| GL186_RS03490 (GL186_03595) | - | 690175..690390 (+) | 216 | WP_000807422.1 | YdbC family protein | - |
| GL186_RS11060 | - | 690387..690533 (-) | 147 | WP_001809980.1 | hypothetical protein | - |
| GL186_RS03500 (GL186_03605) | - | 690595..691131 (-) | 537 | WP_000709036.1 | biotin transporter BioY | - |
| GL186_RS03505 (GL186_03610) | - | 691557..691895 (+) | 339 | WP_000746105.1 | hypothetical protein | - |
| GL186_RS03510 (GL186_03615) | - | 691961..693943 (+) | 1983 | WP_000768912.1 | hypothetical protein | - |
| GL186_RS03515 (GL186_03620) | - | 693940..694563 (+) | 624 | WP_000151029.1 | ATP-binding cassette domain-containing protein | - |
Sequence
Protein
Download Length: 196 a.a. Molecular weight: 21358.36 Da Isoelectric Point: 4.4910
>NTDB_id=403242 GL186_RS03315 WP_000613477.1 658720..659310(+) (clpP) [Streptococcus pneumoniae strain 566]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN
Nucleotide
Download Length: 591 bp
>NTDB_id=403242 GL186_RS03315 WP_000613477.1 658720..659310(+) (clpP) [Streptococcus pneumoniae strain 566]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGAACAGTCATCGCATCAAGTGGAGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGAACAGTCATCGCATCAAGTGGAGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| clpP | Streptococcus pneumoniae Rx1 |
100 |
100 |
1 |
| clpP | Streptococcus pneumoniae D39 |
100 |
100 |
1 |
| clpP | Streptococcus pneumoniae R6 |
100 |
100 |
1 |
| clpP | Streptococcus pneumoniae TIGR4 |
100 |
100 |
1 |
| clpP | Streptococcus thermophilus LMG 18311 |
92.821 |
99.49 |
0.923 |
| clpP | Streptococcus thermophilus LMD-9 |
92.821 |
99.49 |
0.923 |
| clpP | Streptococcus pyogenes JRS4 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus pyogenes MGAS315 |
90.769 |
99.49 |
0.903 |
| clpP | Streptococcus mutans UA159 |
85.714 |
100 |
0.857 |
| clpP | Lactococcus lactis subsp. lactis strain DGCC12653 |
85.128 |
99.49 |
0.847 |
| clpP | Lactococcus lactis subsp. cremoris KW2 |
84.615 |
99.49 |
0.842 |
| clpP | Bacillus subtilis subsp. subtilis str. 168 |
58.854 |
97.959 |
0.577 |
| clpP | Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 |
58.031 |
98.469 |
0.571 |