Detailed information NTG0402963

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: GLO74_RS04775
• Genome accession: NZ_CP046354
• Coordinates: 895362..896210 (+)
• Length: 282 a.a.
• NCBI ID: WP_000705306.1
• Uniprot ID: A0A098Z7D2
• Organism: Streptococcus pneumoniae strain 310
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 890362..901210

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GLO74_RS04750 (GLO74_04810)	-	891077..891784 (+)	708	WP_000638508.1	IspD/TarI family cytidylyltransferase	-
GLO74_RS04755 (GLO74_04815)	-	891789..892811 (+)	1023	WP_000609885.1	ribitol-5-phosphate dehydrogenase	-
GLO74_RS04760 (GLO74_04820)	licA	892828..893697 (+)	870	WP_000411215.1	choline kinase LicA	-
GLO74_RS04765 (GLO74_04825)	-	893687..894565 (+)	879	WP_000837609.1	DMT family transporter	-
GLO74_RS04770 (GLO74_04830)	-	894577..895266 (+)	690	WP_000643970.1	sugar phosphate nucleotidyltransferase	-
GLO74_RS04775 (GLO74_04835)	dprA/cilB/dalA	895362..896210 (+)	849	WP_000705306.1	DNA-processing protein DprA	Machinery gene
GLO74_RS11265 (GLO74_04840)	-	896394..896516 (-)	123	WP_001814242.1	hypothetical protein	-
GLO74_RS04780 (GLO74_04845)	-	897094..898137 (+)	1044	WP_001812957.1	TIGR00341 family protein	-
GLO74_RS04785 (GLO74_04850)	topA	898304..900391 (+)	2088	WP_000179643.1	type I DNA topoisomerase	-
GLO74_RS04790 (GLO74_04855)	-	900497..900856 (+)	360	WP_001237219.1	YbaN family protein	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31062.72 Da
• Isoelectric Point: 5.4047

>NTDB_id=402963 GLO74_RS04775 WP_000705306.1 895362..896210(+) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 310]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=402963 GLO74_RS04775 WP_000705306.1 895362..896210(+) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 310]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
TCATCTGGTTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• AlphaFold DB: A0A098Z7D2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae D39	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae R6	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	100	100	1
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	98.582	100	0.986
dprA/cilB/dalA	Streptococcus mitis SK321	97.872	100	0.979
dprA	Streptococcus mutans UA159	63.214	99.291	0.628
dprA	Lactococcus lactis subsp. cremoris KW2	55.714	99.291	0.553
dprA	Staphylococcus aureus N315	37.809	100	0.379
dprA	Haemophilus influenzae Rd KW20	38.202	94.681	0.362