Detailed information NTG0039674

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STH8232_RS08115
• Genome accession: NC_017581
• Coordinates: 1568714..1569499 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus JIM 8232
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1563714..1574499

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STH8232_RS08085 (STH8232_1872)	gatC	1563778..1564080 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STH8232_RS08090 (STH8232_1873)	-	1564255..1564473 (-)	219	WP_014621899.1	glycosyl transferase	-
STH8232_RS11975	-	1564412..1564576 (-)	165	WP_231838381.1	glycosyltransferase	-
STH8232_RS08095 (STH8232_1874)	-	1565013..1566454 (-)	1442	Protein_1516	6-phospho-beta-glucosidase	-
STH8232_RS08100 (STH8232_1876)	msrA	1566607..1567116 (-)	510	WP_041829085.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STH8232_RS08105 (STH8232_1877)	-	1567128..1567976 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STH8232_RS08110 (STH8232_1878)	-	1568100..1568651 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
STH8232_RS08115 (STH8232_1879)	codY	1568714..1569499 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STH8232_RS08120 (STH8232_1880)	-	1569759..1570973 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
STH8232_RS08125 (STH8232_1881)	-	1571328..1571780 (+)	453	WP_002946987.1	universal stress protein	-
STH8232_RS10825	-	1571960..1572531 (+)	572	Protein_1523	IS30 family transposase	-
STH8232_RS11425 (STH8232_1884)	-	1572603..1572776 (-)	174	WP_014621904.1	hypothetical protein	-
STH8232_RS08135 (STH8232_1885)	-	1572843..1573211 (-)	369	WP_014621905.1	membrane protein	-
STH8232_RS08140 (STH8232_1887)	pflA	1573423..1574223 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=39674 STH8232_RS08115 WP_002951720.1 1568714..1569499(-) (codY) [Streptococcus thermophilus JIM 8232]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=39674 STH8232_RS08115 WP_002951720.1 1568714..1569499(-) (codY) [Streptococcus thermophilus JIM 8232]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502